Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

4/6/2014 (2 years ago)

Catholic Online (www.catholic.org)

Drug cut in half the risk that cancer would worsen

An important treatment option in the fight against breast cancer may be waiting in the wings. Researchers say a new type of drug could help prevent advanced breast cancer from worsening. The potential is great for breast cancer patients, and makes for a potential blockbuster product for Pfizer.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

4/6/2014 (2 years ago)

Published in Health

Keywords: Pfizer, breast cancer, palbociclib


LOS ANGELES, CA (Catholic Online) - Said drug cut in half the risk that cancer would worsen, or progress, researchers said. The median time before the disease progressed or the women died was 20.2 months for those who received the drug, compared with 10.2 months for the control group.

"The magnitude of benefit we are seeing is not something commonly seen in cancer medicine studies," Dr. Richard S. Finn, a principal investigator in the study, says. Finn, an oncologist at the University of California, Los Angeles, called the results "quite groundbreaking."

No child need ever go to bed hungry -- Learn how you can help!


Known as palbociclib, the drug also appeared to prolong survival but not by a statistically significant amount. Those who received the drug lived a median of 37.5 months in contrast with 33.3 months for those in the control group.

The results from the Phase 2, or mid-stage, study were presented here at the annual meeting of the American Association for Cancer Research. Palbociclib is considered a jewel in Pfizer's product pipeline, with analysts predicting annual sales of billions of dollars. Amgen is entitled to an eight percent royalty on sales of the drug.

Some investors may have been letdown due to the drug, partly because they were not quite as good as interim results presented about halfway through the trial. At that point, the difference in median progression-free survival was 26.1 months for palbociclib versus 7.5 months for the control group.

Finn stresses that a statistically significant survival benefit should not have been expected at this point because only 61 of the 165 patients in the trial had died. Patients can use other drugs after leaving the trial, which can dilute any effect of palbociclib.

Palbociclib slows the proliferation of cancer cells by inhibiting the activity of two related enzymes involved in cell division; cyclin-dependent kinases 4 and 6.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor. While breast cancer is the initial focus, the drugs are being tested for other cancers.

Breast cancer specialists not involved in the study were encouraged -- but expressed caution. "These results are strikingly positive and with a large potential impact to patients," Dr. José Baselga said in a speech at the conference discussing the results.

Baselga, the physician in chief at the Memorial Sloan-Kettering Cancer Center, also said the results might have been biased because the study investigators, who determined whether tumors had progressed, knew which patients were getting palbociclib.

Dr. Eric P. Winer, chief of women's cancers at the Dana-Farber Cancer Institute in Boston, says larger studies were still needed.

"This is a small Phase 2 trial - not tiny, but not the kind of study that would typically lead to a change in practice," he said.

---


Pope Francis: end world hunger through 'Prayer and Action'


Copyright 2016 - Distributed by THE CALIFORNIA NETWORK

Pope Francis Prayer Intentions for June 2016
Universal:
Human Solidarity: That the aged, marginalized, and those who have no one may find–even within the huge cities of the world–opportunities for encounter and solidarity.
Evangelization: Seminarians and Novices: That seminarians and men and women entering religious life may have mentors who live the joy of the Gospel and prepare them wisely for their mission.



Comments


More Health

Social anxiety a thing of the past? Scientists observe OXT Watch

Image of Are your social skills lacking? It may be in your genes (Shutterstock).

By Kenya Sinclair (CALIFORNIA NETWORK)

Have you always been more of a loner than social butterfly? Science may have proven why that is. LOS ANGELES, CA (Catholic Online) - Scientists may have found a reason why you're more comfortable alone than at a party.According to a study conducted by the University of ... continue reading


Top 7 healthy summer snacks Watch

Image of If you live in a region where the summer heat drains the energy out of you, these healthy summer treats are right up your alley (Gina's Recipes)!

By Kenya Sinclair (CALIFORNIA NETWORK)

Take a look at our top seven beautiful, delicious and healthy summer snacks! LOS ANGELES, CA (Catholic Online) - Images of sunny beaches, warm breezes, lake swims, ice cream and the laughter of children come to mind when we think of summer - but let's face it, we ALL ... continue reading


'We're sort of in a hard place': 234 pregnant women in U.S. diagnosed with Zika Watch

Image of Over 200 pregnant women in the U.S. have been diagnosed with the incurable Zika virus (Alamy).

By Kenya Sinclair (CALIFORNIA NETWORK)

No one is immune - over 200 pregnant women in the United States have been diagnosed with the Zika virus. LOS ANGELES, CA (Catholic Online) - A new CDC report revealed 234 pregnant women in the United States have been diagnosed with the Zika virus.Thus far, three babies ... continue reading


Can 'ethically acceptable' stem cell therapy cure MS? Watch

Image of Can stem cells cure MS (WikiMedia Commons)?

By (CNA/EWTN News)

A risky adult stem cell clinical trial in Canada has proven effective in stopping and even reversing the symptoms in patients with severe cases of multiple sclerosis, a progressive disease of the immune system that is often untreatable. Ontario, Canada (CNA/EWTN News) ... continue reading


Archbishop speaks out after California legalizes assisted suicide Watch

Image of Why offer end of life options if assisted suicide is the next best thing (thislittlecreekhealthcare)?

By (CNA/EWTN News)

Assisted suicide will change California for the worse, Archbishop Jose Gomez of Los Angeles said on Wednesday, adding that Catholics and others must take action to show they will care for the ailing, not aid in killing them. Los Angeles, CA (CNA/EWTN News) - "With the ... continue reading


SICK and SAD: England approves procedure that allows a baby to have 3 parents, but it kills dozens of others in the process Watch

Image of Doctors can now create a baby with donated mitochondria from a second mother.

By Marshall Connolly (CALIFORNIA NETWORK)

In England, it is now both possible and legal to have a child with three biological parents. The process is called "three person IVF." The practice is fraught with ethical concerns. LOS ANGELES, CA (California Network) - Three person in-vitro fertilization can allow ... continue reading


Should I kill myself or buy a t-shirt? Watch

Image of Between the tee shirt shops and the pot shops, is a place for people to obtain poison to end their lives.

By Marshall Connolly (CALIFORNIA NETWORK)

Should I kill myself or buy a t-shirt? This is the question some visitors to Berkeley might have as they visit the college town just east of Oakland. The reason is that California's "right to die" law goes into effect today and along with it, the first clinic ... continue reading


Does cellphone radiation REALLY cause cancer? Watch

Image of Research indicates cellular radiation causes cancer in rats - but does it do the same to humans (motion.pl/Shutterstock)?

By Kenya Sinclair (CALIFORNIA NETWORK)

A new study reveals startling information concerning cancers growing in rats exposed to cell phone radiation. How safe are you from similar cancers? LOS ANGELES, CA (Catholic Online) - The study, conducted by research and education institution bioRxiv, revealed ... continue reading


Woman diagnosed with 'nightmare bacteria' in US Watch

Image of A woman has been diagnosed with a frightening E. coli superbug in Pennsylvania (Inhabitat).

By Kenya Sinclair (CALIFORNIA NETWORK)

A 49-year-old Pennsylvanian woman who has not stepped foot outside the United States within the past several months was recently diagnosed with the first case of its kind in the US - a drug-resistant form of E. coli. LOS ANGELES, CA (Catholic Online) - The CDC and ... continue reading


HORRIFYING: Abortion mill calls 911 to save baby after botched abortion Watch

Image of A baby is a human being, even before it is born. There should be no question of its right to life.

By Marshall Connolly (CALIFORNIA NETWORK)

A chilling recording has been released on a 911 call from an abortion mill, requesting emergency services for a baby who survived an abortion. The call was placed earlier this year and left people wondering about the fate of the baby. It also raised the issue of the ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Subscribe to Catholic OnlineYouTube Channel

the FEED
by Catholic Online

  • Prayer in Time of Bereavement HD Video
  • ISIS spy finds Jesus
  • Daily Readings for Tuesday, June 28, 2016
  • 'Woman's thought is important': Pope Francis on women deacons
  • The Vindication of Governor Bob McDonnell, Persevering Faith and the ...
  • Prayer to Our Lady, Health of the Sick HD Video
  • St. Irenaeus: Saint of the Day for Tuesday, June 28, 2016

Daily Readings

Reading 1, Amos 3:1-8; 4:11-12
1 Listen, Israelites, to this prophecy which Yahweh pronounces against ... Read More

Psalm, Psalms 5:4-6, 6-7, 8
4 You are not a God who takes pleasure in evil, no sinner can be your ... Read More

Gospel, Matthew 8:23-27
23 Then he got into the boat followed by his disciples.24 ... Read More

Saint of the Day

Saint of the Day for June 28th, 2016 Image

St. Irenaeus
June 28: The writings of St. Irenaeus entitle him to a ... Read More