Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

4/6/2014 (1 year ago)

Catholic Online (www.catholic.org)

Drug cut in half the risk that cancer would worsen

An important treatment option in the fight against breast cancer may be waiting in the wings. Researchers say a new type of drug could help prevent advanced breast cancer from worsening. The potential is great for breast cancer patients, and makes for a potential blockbuster product for Pfizer.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

4/6/2014 (1 year ago)

Published in Health

Keywords: Pfizer, breast cancer, palbociclib


LOS ANGELES, CA (Catholic Online) - Said drug cut in half the risk that cancer would worsen, or progress, researchers said. The median time before the disease progressed or the women died was 20.2 months for those who received the drug, compared with 10.2 months for the control group.

"The magnitude of benefit we are seeing is not something commonly seen in cancer medicine studies," Dr. Richard S. Finn, a principal investigator in the study, says. Finn, an oncologist at the University of California, Los Angeles, called the results "quite groundbreaking."

No child need ever go to bed hungry -- Learn how you can help!


Known as palbociclib, the drug also appeared to prolong survival but not by a statistically significant amount. Those who received the drug lived a median of 37.5 months in contrast with 33.3 months for those in the control group.

The results from the Phase 2, or mid-stage, study were presented here at the annual meeting of the American Association for Cancer Research. Palbociclib is considered a jewel in Pfizer's product pipeline, with analysts predicting annual sales of billions of dollars. Amgen is entitled to an eight percent royalty on sales of the drug.

Some investors may have been letdown due to the drug, partly because they were not quite as good as interim results presented about halfway through the trial. At that point, the difference in median progression-free survival was 26.1 months for palbociclib versus 7.5 months for the control group.

Finn stresses that a statistically significant survival benefit should not have been expected at this point because only 61 of the 165 patients in the trial had died. Patients can use other drugs after leaving the trial, which can dilute any effect of palbociclib.

Palbociclib slows the proliferation of cancer cells by inhibiting the activity of two related enzymes involved in cell division; cyclin-dependent kinases 4 and 6.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor. While breast cancer is the initial focus, the drugs are being tested for other cancers.

Breast cancer specialists not involved in the study were encouraged -- but expressed caution. "These results are strikingly positive and with a large potential impact to patients," Dr. Josť Baselga said in a speech at the conference discussing the results.

Baselga, the physician in chief at the Memorial Sloan-Kettering Cancer Center, also said the results might have been biased because the study investigators, who determined whether tumors had progressed, knew which patients were getting palbociclib.

Dr. Eric P. Winer, chief of women's cancers at the Dana-Farber Cancer Institute in Boston, says larger studies were still needed.

"This is a small Phase 2 trial - not tiny, but not the kind of study that would typically lead to a change in practice," he said.

---


Pope Francis: end world hunger through 'Prayer and Action'


Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for March 2015
Universal:
Scientists: That those involved in scientific research may serve the well-being of the whole human person.
Evangelization: Contribution of women: That the unique contribution of women to the life of the Church may be recognized always.


Rosaries, Crosses, Prayer Cards and more... by Catholic Shopping .com


Comments


More Health

HUNG OVER? Try the ancient Egyptian cure - of a garland of laurel leaves Watch

Image of Written in Greek, the cure advises stringing together the leaves of the Alexandrian Laurel and wearing it like a necklace.

By Catholic Online (NEWS CONSORTIUM)

There may be a reason behind all those surviving artworks of drunken, ancient Roman revelers wearing garlands about their heads. In a stash of more than half a million documents unearthed in an ancient trash heap in the Egyptian town of Oxyrhynchus in 1896, the ... continue reading


ALTERING EMBRYOS: China becoming 'Wild West' in genetic research Watch

Image of Used in adult cells and animal models, the technique had previously never been used in connection with human embryos.

By Catholic Online (NEWS CONSORTIUM)

Critics warn that China is swiftly becoming the "Wild West" of genetic research. Researchers at the Sun Yat-sen University in Guangzhou have confirmed they had engineered embryos to modify the gene responsible for the fatal blood disorder thalassaemia. The team ... continue reading


Surgeon claims controversial head transplant will take less than an hour Watch

Image of Surgeon Sergio Canavero said that he would explain the procedure in depth at a neurosurgeons' conference this coming June 12.

By Catholic Online (NEWS CONSORTIUM)

Italian surgeon Sergio Canavero says that he can reattach a man's head on to a new body in less than an hour. Canavero says that the procedure is just the first step in a series of steps towards his ultimate aim of creating immortality. LOS ANGELES, CA ... continue reading


'If I Only Had a Brain': MRI technology gives an amazing inside look into a singing brain Watch

Image of

By Atarah Haely (NEWS CONSORTIUM)

Researchers from the Beckman Institute investigated how various muscles and other connected body parts work to allow us to speak and sing, and the changes that happen over time. Analyzing how the human voice works and the variations it undergoes at age, a former ... continue reading


Behind the heroic act: The heartbreaking story of the youngest organ donor in Britain Watch

Image of

By Hannah Raissa Marfil (NEWS CONSORTIUM)

Teddy Houlston would have celebrated his first birthday this year with his family and twin brother. But he was not able to live for an entire day; baby Teddy was diagnosed with a condition called anencephaly within twelve weeks inside his mother's womb. Heartbreaking ... continue reading


Listeria outbreak in Blue Bell Creameries, causing them to recall all products, started in 2010 Watch

Image of According to CDC's investigation, they made comparisons with the patients dating back 2010 up to the current outbreak.

By Nikky Andres (NEWS CONSORTIUM)

Based on the investigation made by the Centers for Disease Control (CDC), the listeria outbreak in Blue Bell Creameries, that has caused them to recall all of their ice cream, started back in 2010. MUNTINLUPA, PHILIPPINES (Catholic Online) - The Blue Bell Creameries ... continue reading


Taking a multivitamin for your health? 'Healthy' multivitamins may increase risk for certain diseases by more than 50 percent Watch

Image of New research suggests that taking some commonly used multivitamins may actually be very harmful to your health.

By Matt Waterson (NEWS CONSORTIUM)

Multivitamins have long been a staple of what many would call a "healthy" lifestyle, and the market for these pills is flooded with products that target every single demographic including post-menopausal women, teens, bodybuilders and diabetics. However, new ... continue reading


'Turbo-charging' immune system to kill all known cancers in development Watch

Image of Scientists at Imperial College London, who led the study, are now developing a gene therapy based on the protein and hope to begin human trials in three years.

By Catholic Online (NEWS CONSORTIUM)

A protein which "turbo-charges" the immune system, enabling it to fight off any cancer or virus, has been discovered by scientists. Described as a "game-changer" for cancer treatment, researchers at Imperial College in the United Kingdom have found a previously ... continue reading


Negative relationships really are unhealthy: New research shows high blood pressure linked to stressful relationships Watch

Image of

By Atarah Haely (NEWS CONSORTIUM)

Bad relationship status may cause physiological health deterioration. The research, conducted by a team from the University of Michigan, discovered men are more sensitive with regards to the stress levels of their wives or partners. These stress levels, from negative ... continue reading


Killer high heels cause long lasting body damage Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

Fashion is such a big thing, especially for women. These days, for you to belong to the "it-crowd," you have to be stylish and popular in your social media posts, or you constantly have to update your fashion blog with the latest trends in clothing, shoes, and ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Acts 4:8-12
8 Then Peter, filled with the Holy Spirit, addressed ... Read More

Psalm, Psalms 118:1, 8-9, 21-23, 26, 21, 29
1 Alleluia! Give thanks to Yahweh for he is good, for ... Read More

Gospel, John 10:11-18
11 I am the good shepherd: the good shepherd lays ... Read More

Reading 2, First John 3:1-2
1 You must see what great love the Father has ... Read More

Saint of the Day

Saint of the Day for April 26th, 2015 Image

St. Cletus
April 26: St. Cletus was the third bishop of Rome, and succeeded St. ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter