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By Catholic Online (NEWS CONSORTIUM)

3/3/2014 (1 year ago)

Catholic Online (www.catholic.org)

Protein found to extend lives of mice, delay age-related illnesses

A new medical discovery in the form of a pill could ward off ageing has come closer to reality. A protein, called sirtuin 1, or SIRT1 has been found to extend the lives of mice and delayed the onset of age-related diseases. This could in turn lead to drugs that can apply to human subjects.

Both Sirtuin 1 and 2 proteins are involved in DNA repair and gene regulation, and may help to prevent diabetes, heart disease and cancer.

Both Sirtuin 1 and 2 proteins are involved in DNA repair and gene regulation, and may help to prevent diabetes, heart disease and cancer.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

3/3/2014 (1 year ago)

Published in Technology

Keywords: Situin1, longevity, age-related illnesses


LOS ANGELES, CA (Catholic Online) - Researchers believe their experiments could lead to drugs that help to keep people younger and healthier. SIRT1, along with its sister protein, SIRT2 are known to play an important roles in metabolism across a wide range of species.

Both proteins are involved in DNA repair and gene regulation, and may help to prevent diabetes, heart disease and cancer.

Rafael de Cabo researchers, from the U.S. National Institutes of Health Researchers tested the effects of a SIRT1-activating molecule called SRT1720 on the health and lifespan of mice.

The test subjects that were fed a standard diet supplemented with 100 milligrams per kilogram of body weight of SRT1720 from the age of six months.

The researchers found that SRT1720 significantly extended the average lifespan of mice by 8.8 percent. Mice fed the molecule were found to weigh less and appeared slimmer, with better muscle function and co-ordination throughout their lives.

Further studies showed that SRT1720 supplementation led to a heart-protective lowering of harmful cholesterol and improved insulin sensitivity, which could help prevent diabetes. Another health benefit found were anti-inflammatory effects, which were also seen in various tissues. This is important because chronic low-level inflammation is believed to contribute to ageing and age-related diseases.

"Here, we show for the first time that a synthetic SIRT1 activator extends lifespan and improves health span of mice fed a standard diet," Dr de Cabo says.

"It illustrates that we can develop molecules that ameliorate the burden of metabolic and chronic diseases associated with ageing."

You may want to skip your next barbecue with this next bit of news: Previous research has found that eating barbecued, grilled or fried meat could increase the risk of being struck down by dementia.

Experts in the United States found that compounds called advanced glycation end products, or Ages, suppress the anti-ageing enzyme known as Sirt1.

Protein-rich foods that are cooked at very high temperatures raise the level of these harmful Ages in blood.

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