Skip to content

Stem cell model for bipolar disorder may lead to new treatments

By Catholic Online (NEWS CONSORTIUM)
3/27/2014 (3 years ago)
Catholic Online (www.catholic.org)

Researchers analyzed skin samples from bipolar patients

Bipolar disorder is one of the ore common examples of mental illness. Those who suffer from bipolar disorder suffer drastic mood swings - from ecstatic happiness to the depths of despair. It's not yet known what causes it. Researchers from the University of Michigan Medical School have now created the first stem cell model for bipolar disorder. They hope that the model will uncover the origins of the condition and open the door to new treatments.

Bipolar disorder is one of the ore common examples of mental illness. Those who suffer from bipolar disorder suffer drastic mood swings - from ecstatic happiness to the depths of despair.

Bipolar disorder is one of the ore common examples of mental illness. Those who suffer from bipolar disorder suffer drastic mood swings - from ecstatic happiness to the depths of despair.

Highlights

By Catholic Online (NEWS CONSORTIUM)
Catholic Online (www.catholic.org)
3/27/2014 (3 years ago)

Published in Health

Keywords: Stem cell research, bipolar disorder, research


LOS ANGELES, CA (Catholic Online) - Investigators obtained skin samples from people with bipolar disorder along with skin samples from individuals without the condition.

Exposing small samples of skin cells to carefully controlled conditions, the researchers turned them into induced pluripotent stem cells, or iPSCs. These are stem cells that have the potential to be turned into any other type of cell. The team then turned the iPSCs into neurons.

No child need ever go to bed hungry -- go here!

Researchers then measured gene expression of the iPSCs and then re-evaluated gene expression once the stem cells became neurons. The team found significant differences between the stem cells taken from bipolar patients from those without the condition.

Stem cell lines were made from the skin of bipolar patients. Researchers found that the neurons from bipolar patients expressed more genes for membrane receptors and ion channels than the neurons from non-bipolar patients. This was particularly true for genes for receptors and channels involved in sending and receiving calcium signals between cells.

As calcium signals play a significant role in neuron development and function, the investigators say their findings suggest that genetic differences in early brain development may contribute to the development of bipolar and other mental health conditions later in life.

Researchers exposed the neurons to lithium, which is a chemical that bipolar patients often use to regulate their mood, signaling that patterns had changed.

Researchers explain that lithium changes how calcium signals are sent and received. These new cell lines will allow them to determine the mechanisms behind this in cells specific to bipolar patients.

Bipolar disorders affects approximately 5.7 million adults in the US every year.

Bipolar disorder is currently treated with various medications, such as mood stabilizers, antidepressants and antipsychotics. Not all bipolar patients respond to them in the same way and many are left with uncontrolled symptoms.

"We're very excited about these findings" study author Melvin McInnis, of the Department of Psychiatry at the University of Michigan Medical School, says. He notes that this stem cell model could lead to personalized treatment for bipolar disorder.

He does qualify the recent findings. "But we're only just beginning to understand what we can do with these cells to help answer the many unanswered questions in bipolar disorder's origins and treatment.

"For instance, we can now envision being able to test new drug candidates in these cells, to screen possible medications proactively instead of having to discover them fortuitously."

---


'Help give every student and teacher Free resources for a world-class moral Catholic education'


Copyright 2017 - Distributed by THE CALIFORNIA NETWORK

Pope Francis Prayer Intentions for OCTOBER 2017
Workers and the Unemployed.
That all workers may receive respect and protection of their rights, and that the unemployed may receive the opportunity to contribute to the common good.


Comments


More Health

Sorry, there's no science to support 'transgender therapy' for kids Watch

Image of Sex is determined by DNA, and cannot be biologically changed with therapy.

Children who struggle to match their gender identity with their biological sex should not be pushed into transgender therapies, but given ... continue reading


SCARY! Science says there's a downside to curing cancer Watch

Image of Modern healthcare has suppressed the culling effect of natural selection, leading to a resurgence of genetic illnesses. However, modern technology can offer a permanent solution.

Why are cancer rates up to 14 times higher in countries with advanced healthcare? It's because there are more cancer survivors, and they ... continue reading


Here's the one big reason why Trump euthanized Obamacare Watch

Image of President Trump is sending Congress to work on rebuilding healthcare so it is more sustainable and affordable.

In 2016, voters sent Republicans to Washington with a mandate to end Obamacare. The law was spiteful, particularly towards Christians, ... continue reading


What does the Catholic Church say about vaccines? Woman faces jail for refusing to vaccinate child Watch

Image of Vaccinations are a pillar of modern healthcare, but should we be forced to participate?

A woman faces jail time for contempt of court, should she refuse a judge's order to vaccinate her nine-year-old son. Rebecca Bredow is ... continue reading


Obamacare repeal fails again! What happens next? Watch

Image of They ran on a promise to repeal Obamacare and to get something done, but nothing ever changes. Why do people keep electing them?

The latest attempt to repeal Obamacare has failed. The Graham-Cassidy bill failed overnight leaving Obamacare as the law of the land. It is ... continue reading


Never Miss any Updates!

Stay up to date with the latest news, information, and special offers.

Information
Learn about Catholic world

Catholic Online
Inform - Inspire - Ignite

Catholic Online Saints
Your saints explained

Catholic Online Prayers
Prayers for every need

Catholic Online Bible
Complete bible online

Catholic Online News
Your news Catholic eye

Daily Reading
Today's bible reading

Lent / Easter
Death & resurrection of Jesus

Advent / Christmas
Birth of Jesus

Rest of Catholic Online
All Catholic world we offer

Services
Products and services we offer

Catholic Online Shopping
Catholic medals, gifts & books

The California Network
Inspiring streaming service

Advertise on Catholic Online
Your ads on catholic.org

Catholic Online Email
Email with Catholic feel

Catholic Online Singles
Safe, secure Catholic dating

The California Studios
World-class post production service

Education
Learn the Catholic way

Catholic Online School
Free Catholic education for all

Student Classes
K-12 & Adult Education Classes

Catholic Online MasterClass
Learn from experts

School Teachers
Teacher lesson plans & resources

Catholic Media Missionaries
The New Evangelization

Support Free Education
Tax deductible support Free education

Socials
Connect with us online

Catholic Online on Facebook
Catholic social network

Catholic Online on Twitter
Catholic Tweets

Catholic Online on YouTube
Enjoy our videos

Catholic Online on Instagram
Shared Catholic moments

Catholic Online on Pinterest
Catholic ideas style inspiration

Catholic Online Logo

Copyright 2017 Catholic Online. All materials contained on this site, whether written, audible or visual are the exclusive property of Catholic Online and are protected under U.S. and International copyright laws, © Copyright 2017 Catholic Online. Any unauthorized use, without prior written consent of Catholic Online is strictly forbidden and prohibited.