Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

3/27/2014 (2 years ago)

Catholic Online (

Researchers analyzed skin samples from bipolar patients

Bipolar disorder is one of the ore common examples of mental illness. Those who suffer from bipolar disorder suffer drastic mood swings - from ecstatic happiness to the depths of despair. It's not yet known what causes it. Researchers from the University of Michigan Medical School have now created the first stem cell model for bipolar disorder. They hope that the model will uncover the origins of the condition and open the door to new treatments.

Bipolar disorder is one of the ore common examples of mental illness. Those who suffer from bipolar disorder suffer drastic mood swings - from ecstatic happiness to the depths of despair.

Bipolar disorder is one of the ore common examples of mental illness. Those who suffer from bipolar disorder suffer drastic mood swings - from ecstatic happiness to the depths of despair.


By Catholic Online (NEWS CONSORTIUM)

Catholic Online (

3/27/2014 (2 years ago)

Published in Health

Keywords: Stem cell research, bipolar disorder, research

LOS ANGELES, CA (Catholic Online) - Investigators obtained skin samples from people with bipolar disorder along with skin samples from individuals without the condition.

Exposing small samples of skin cells to carefully controlled conditions, the researchers turned them into induced pluripotent stem cells, or iPSCs. These are stem cells that have the potential to be turned into any other type of cell. The team then turned the iPSCs into neurons.

No child need ever go to bed hungry -- go here!

Researchers then measured gene expression of the iPSCs and then re-evaluated gene expression once the stem cells became neurons. The team found significant differences between the stem cells taken from bipolar patients from those without the condition.

Stem cell lines were made from the skin of bipolar patients. Researchers found that the neurons from bipolar patients expressed more genes for membrane receptors and ion channels than the neurons from non-bipolar patients. This was particularly true for genes for receptors and channels involved in sending and receiving calcium signals between cells.

As calcium signals play a significant role in neuron development and function, the investigators say their findings suggest that genetic differences in early brain development may contribute to the development of bipolar and other mental health conditions later in life.

Researchers exposed the neurons to lithium, which is a chemical that bipolar patients often use to regulate their mood, signaling that patterns had changed.

Researchers explain that lithium changes how calcium signals are sent and received. These new cell lines will allow them to determine the mechanisms behind this in cells specific to bipolar patients.

Bipolar disorders affects approximately 5.7 million adults in the US every year.

Bipolar disorder is currently treated with various medications, such as mood stabilizers, antidepressants and antipsychotics. Not all bipolar patients respond to them in the same way and many are left with uncontrolled symptoms.

"We're very excited about these findings" study author Melvin McInnis, of the Department of Psychiatry at the University of Michigan Medical School, says. He notes that this stem cell model could lead to personalized treatment for bipolar disorder.

He does qualify the recent findings. "But we're only just beginning to understand what we can do with these cells to help answer the many unanswered questions in bipolar disorder's origins and treatment.

"For instance, we can now envision being able to test new drug candidates in these cells, to screen possible medications proactively instead of having to discover them fortuitously."


Pope Francis: end world hunger through 'Prayer and Action'

Copyright 2016 - Distributed by THE CALIFORNIA NETWORK

Pope Francis Prayer Intentions for SEPTEMBER 2016
Centrality of the Human Person: That each may contribute to the common good and to the building of a society that places the human person at the center.
Evangelization: Mission to Evangelize: That by participating in the Sacraments and meditating on Scripture, Christians may become more aware of their mission to evangelize.


More Health

Science knows of a 100 percent effective cure for antibiotic resistant STDs, so why aren't we using it? Watch

Image of Scientists know about an amazing STD solution that is 100 percent effective. So why aren't we using it?


Sexually transmitted diseases are on the rise in America, reaching levels never before seen by doctors. LOS ANGELES, CA (California Network) - Sexually transmitted diseases (STD) are on the rise in America, likely fueled by increased sexual promiscuity and growing ... continue reading

Researchers have discovered the human body's expiration date Watch

Image of Researchers claim the human body is incapable of exceeding a certain number of years.


Scientists have been reporting the average life expectancy for years, but new evidence suggests the human body is incapable of functioning after a certain amount of time. LOS ANGELES, CA (Catholic Online) - Researchers from the Albert Einstein College of Medicine's ... continue reading

'What we gain in Christ is much greater than what we've lost' - Woman turns to God after illness sweeping U.S. hits home Watch

Image of Children in the US have been developing a polio-like illness (Facebook).


On Monday, the CDC reported a rise in acute flaccid myelitis (AFM) across the U.S., resulting in 50 cases within seven months. LOS ANGELES, CA (Catholic Online) - Between January and August, the CDC reported fifty cases of the horrific disease that can leave children ... continue reading

HIV 'vanishes' from 44-year-old British man's blood Watch

Image of First man cured of HIV uses new therapy (Michael Jung/Shutterstock).


A new therapy for HIV patients has resulted in its first success! LOS ANGELES, CA (Catholic Online) - According to the <a href="">Telegraph</a>, a ... continue reading

'This is really a frightening situation' - 23k dead in global crisis Watch

Image of Thousands die each year as antibiotic-resistant infections strike hard.


Humanity has battled a terrifying foe responsible for stealing the lives of countless people. In the 1920's, when mankind finally found a way to overpower the deadly threat, we thought the war was won - but now, the danger has returned and is jeopardizing the lives of ... continue reading

Birth control leads to depression, increased risk of breast cancer and more Watch

Image of What impact does birth control have on your hormones?

By (CNA/EWTN News)

For the millions of women using hormonal birth control, side effects are nothing new. Washington D.C. (CNA/EWTN News) - Headaches, mood swings and weight gain are all commonly reported side effects, not to mention more serious problems such as blood clots and ... continue reading

God is good! Man learns to walk after FOUR DECADES in wheelchair Watch

Image of Rufino Borrego (not pictured) no longer requires his wheelchair.


Rufino Borrego was only 13-years-old when he was diagnosed with muscular dystrophy, leading to 43-years of his life spent confined to a wheelchair. LOS ANGELES, CA (Catholic Online) - Borrego was diagnosed by doctors at a Lisbon hospital and he spent the majority of ... continue reading

5 things you NEED to know about drug-resistant superbugs and antimicrobial resistance Watch

Image of Do YOU know how to protect yourself?


The United Nations General Assembly voted to take "a broad coordinated approach" to antimicrobial resistance, which is growing at such an alarming rate, millions are expected to die by 2050. LOS ANGELES, CA (Catholic Online) - "This is only the fourth time a health ... continue reading

St. Padre Pio helps dying newborn miraculously recover after 25 DAYS on life support Watch

Image of (Photo by: Ciara Wilkinson/Irish Mirror)


Three-month-old Caitlin Dooley suffered from a life-threatening heart condition since the day she was born. Just when the Dooley family began to lose hope, St. Padre Pio stepped in. LOS ANGELES, CA (Catholic Online) - According to the Irish Mirror, at just 11-days-old, ... continue reading

Pray for the children with brain cancer - the number 1 cancer responsible for childhood deaths Watch

Image of The number one cancer killing children in the US is of the brain.


A new federal report revealed brain cancer is now the leading cancer killer of children in the United States. LOS ANGELES, CA (Catholic Online) - Sally Curtin and her colleagues at the NCHS, part of the CDC, discovered brain tumors and leukemia are the two  most ... continue reading

All Health News


Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Subscribe to Catholic OnlineYouTube Channel

Daily Readings

Reading 1, Ephesians 5:21-33
21 Be subject to one another out of reverence for Christ.22 ... Read More

Psalm, Psalms 128:1-2, 3, 4-5
1 [Song of Ascents] How blessed are all who fear Yahweh, who walk in his ... Read More

Gospel, Luke 13:18-21
18 He went on to say, 'What is the kingdom of God like? What shall I ... Read More

Saint of the Day

Saint of the Day for October 25th, 2016 Image

St. Daria
October 25: There is very little known about them. ... Read More