Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

3/27/2014 (2 years ago)

Catholic Online (www.catholic.org)

Researchers analyzed skin samples from bipolar patients

Bipolar disorder is one of the ore common examples of mental illness. Those who suffer from bipolar disorder suffer drastic mood swings - from ecstatic happiness to the depths of despair. It's not yet known what causes it. Researchers from the University of Michigan Medical School have now created the first stem cell model for bipolar disorder. They hope that the model will uncover the origins of the condition and open the door to new treatments.

Bipolar disorder is one of the ore common examples of mental illness. Those who suffer from bipolar disorder suffer drastic mood swings - from ecstatic happiness to the depths of despair.

Bipolar disorder is one of the ore common examples of mental illness. Those who suffer from bipolar disorder suffer drastic mood swings - from ecstatic happiness to the depths of despair.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

3/27/2014 (2 years ago)

Published in Health

Keywords: Stem cell research, bipolar disorder, research


LOS ANGELES, CA (Catholic Online) - Investigators obtained skin samples from people with bipolar disorder along with skin samples from individuals without the condition.

Exposing small samples of skin cells to carefully controlled conditions, the researchers turned them into induced pluripotent stem cells, or iPSCs. These are stem cells that have the potential to be turned into any other type of cell. The team then turned the iPSCs into neurons.

No child need ever go to bed hungry -- go here!

Researchers then measured gene expression of the iPSCs and then re-evaluated gene expression once the stem cells became neurons. The team found significant differences between the stem cells taken from bipolar patients from those without the condition.

Stem cell lines were made from the skin of bipolar patients. Researchers found that the neurons from bipolar patients expressed more genes for membrane receptors and ion channels than the neurons from non-bipolar patients. This was particularly true for genes for receptors and channels involved in sending and receiving calcium signals between cells.

As calcium signals play a significant role in neuron development and function, the investigators say their findings suggest that genetic differences in early brain development may contribute to the development of bipolar and other mental health conditions later in life.

Researchers exposed the neurons to lithium, which is a chemical that bipolar patients often use to regulate their mood, signaling that patterns had changed.

Researchers explain that lithium changes how calcium signals are sent and received. These new cell lines will allow them to determine the mechanisms behind this in cells specific to bipolar patients.

Bipolar disorders affects approximately 5.7 million adults in the US every year.

Bipolar disorder is currently treated with various medications, such as mood stabilizers, antidepressants and antipsychotics. Not all bipolar patients respond to them in the same way and many are left with uncontrolled symptoms.

"We're very excited about these findings" study author Melvin McInnis, of the Department of Psychiatry at the University of Michigan Medical School, says. He notes that this stem cell model could lead to personalized treatment for bipolar disorder.

He does qualify the recent findings. "But we're only just beginning to understand what we can do with these cells to help answer the many unanswered questions in bipolar disorder's origins and treatment.

"For instance, we can now envision being able to test new drug candidates in these cells, to screen possible medications proactively instead of having to discover them fortuitously."

---


'Help give every student and teacher Free resources for a world-class moral Catholic education'


Copyright 2017 - Distributed by THE CALIFORNIA NETWORK

Pope Francis Prayer Intentions for DECEMBER 2016
Universal:
End to Child-Soldiers: That the scandal of child-soldiers may be eliminated the world over.
Evangelization: Europe: That the peoples of Europe may rediscover the beauty, goodness, and truth of the Gospel which gives joy and hope to life.



Comments


More Health

Ask DMU: 5 Factors for Solid Therapy Watch

Image of

By William T. McKenna, M.S

As we approach both Christmas and the New Year, many of us like to take stock of the past year and to make concrete plans for the next. Usually those plans involve improving ourselves in some way, and therapy is one avenue to take when looking towards self-improvement. ... continue reading


Is this the way the world ends? Humans have officially lost the war against bacteria Watch

Image of Klebsiella pneumoniae is a common bacteria found virtually everywhere. But at least one strain is resistant to all antibiotics.

By Marshall Connolly (CALIFORNIA NETWORK)

For decades, doctors have warned that germs are evolving faster than we can produce new antibiotics to kill them. Eventually our antibiotics will be powerless and millions will die. We have wondered when that day would arrive. We now have an answer, 2016. LOS ANGELES, ... continue reading


What happens if the Affordable Care Act is repealed? Watch

Image of Republicans have attempted to repeal Obamacare dozens of times. Now, it appears they will finally get their wish. But what happens to us?

By Marshall Connolly (CALIFORNIA NETWORK)

With the Republicans voting to repeal Obamacare many people are wondering what will happen. Here is what we we've learned is possible. LOS ANGELES, CA (California Network) -- The Republicans have pledged to repeal Obamacare, also known as the Affordable Care Act. It ... continue reading


The end of all flu shots? Universal influenza vaccine just around the corner Watch

Image of Is the influenza vaccine imminent?

By Kenya Sinclair (CALIFORNIA NETWORK)

Science has elongated the human lifespan by decades through the invention of vaccines, medication and treatment options for the ill - but there is one cure that has eluded scientists for centuries: the cure to the common cold. LOS ANGELES, CA (Catholic Online) - When ... continue reading


The miraculous story of an atheist doctor who quit performing abortions after a visit from St. Thomas Aquinas Watch

Image of Dr. Stojan Adasevic has since become a major voice for the pro-life movement in Serbia.

By Marshall Connolly (CALIFORNIA NETWORK)

An abortionist abruptly quit performing abortions after he encountered St. Thomas Aquinas in a dream. He has since become an active pro-life voice, working to outweigh the crimes he once committed. LOS ANGELES, CA (California Network) -- In his dreams, he saw a field ... continue reading


Scientists scramble for PLAGUE VACCINE in face of possible BIOLOGICAL WARFARE Watch

Image of Scientists race to find vaccine for the plague.

By Kenya Sinclair (CALIFORNIA NETWORK)

The Medieval disease notorious for killing off one-third of Europe's entire population may be making a comeback - this time aimed straight for the United States. LOS ANGELES, CA (Catholic Online) - The bubonic plague, which originally spread through Europe at the hands ... continue reading


Why is this man suing a Catholic hospital for a hysterectomy? Watch

Image of Jionni Conforti is a woman, according to her DNA, but she believes she is a man. She is suing a Catholic hospital which refused to perform a hysterectomy for her.

By Marshall Connolly (CALIFORNIA NETWORK)

A woman who believes she is a man is suing a Catholic hospital because they have refused to perform an hysterectomy on her. According to a lawsuit, the hospital is obligated to perform the surgery. LOS ANGELES, CA (California Network) -- Jionni Conforti, 33, is a woman ... continue reading


Here are 10 great reasons why Planned Parenthood must be defunded Watch

Image of Republicans are about to exercise their right to choose and abort Planned Parenthood.

By David Drudge (CALIFORNIA NETWORK)

The Ethics and Religious Liberty Commission of the Southern Baptist Convention has published 10 reasons why taxpayers should defund Planned Parenthood. Thanks to the election of Donald Trump and a Republican-controlled House and Senate, this important goal is finally ... continue reading


Spicy discovery may change the future of cancer treatment forever Watch

Image of Scientists believe an ingredient in chili peppers can help cure cancer.

By Monique Crawford (CALIFORNIA NETWORK)

What do breasts, a rock band and science have in common? LOS ANGELES, CA (Catholic Online) - The Red Hot Chili Peppers are a popular rock band but those aren't the chili peppers scientists are excited about.Scientists from Ruhr University in Bochum, Germany discovered ... continue reading


Bill Gates is worried the world isn't ready for a pandemic outbreak of the flu -- What are your odds of dying in the next one? Watch

Image of The Spanish Flu killed between three and six percent of the world's population in just two years.

By Marshall Connolly (CALIFORNIA NETWORK)

Bill Gates is worried that the world is ill prepared to respond to a flu pandemic, should one occur. Doctors believe it is only a matter of time before the next major flu pandemic strikes. What are your odds of death? LOS ANGELES, CA (California Network) -- Bill Gates ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Subscribe to Catholic OnlineYouTube Channel

Daily Readings

Reading 1, Hebrews 9:15, 24-28
15 This makes him the mediator of a new covenant, so that, now that a ... Read More

Psalm, Psalms 98:1, 2-3, 3-4, 5-6
1 [Psalm] Sing a new song to Yahweh, for he has performed wonders, his ... Read More

Gospel, Mark 3:22-30
22 The scribes who had come down from Jerusalem were saying, 'Beelzebul ... Read More

Saint of the Day

Saint of the Day for January 23rd, 2017 Image

St. Ildephonsus
January 23: St. Ildephonsus is highly regarded in Spain and ... Read More