Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

6/18/2014 (1 year ago)

Catholic Online (www.catholic.org)

Trials conducted on laboratory mice prove successful; human trial to begin next year

An old drug used in the treatment of sleeping sickness has also temporarily reversed symptoms of autism in mice, researchers have claimed. Researchers say the drug restored normal cellular signaling in a mouse model of autism in animals that were the human biological age equivalent of 30 years old. The results came with a caveat: the effects in the laboratory only lasted for around five weeks.

Suramin, a well-known inhibitor of purinergic signaling, first synthesized in 1916 and is commonly used to treat trypanosomiasis or African sleeping sickness, a parasitic disease was used in trial runs on the mice.

Suramin, a well-known inhibitor of purinergic signaling, first synthesized in 1916 and is commonly used to treat trypanosomiasis or African sleeping sickness, a parasitic disease was used in trial runs on the mice.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

6/18/2014 (1 year ago)

Published in Health

Keywords: Suramin, autism, sleeping sickness, trial tests, mice


LOS ANGELES, CA (Catholic Online) - "Obviously correcting abnormalities in a mouse is a long way from a cure in humans, but we think this approach is a new and fresh way to think about and address the challenge of autism," Robert K. Naviaux at the University of California, San Diego School of Medicine says.

One of the universal symptoms of autism, Naviaux says, is metabolic disturbances.

Get foodinto the hands of needy children -- by going here --

"Cells have a halo of metabolites (small molecules involved in metabolism, the set of chemical processes that maintain life) and nucleotides surrounding them.

"These create a sort of chemical glow that broadcasts the state of health of the cell."

Cells that are threatened or damaged by microbes, such as viruses or bacteria, or by physical forces or by chemicals, such as pollutants, react defensively, a part of the normal immune response. In this case, communications between cells are dramatically reduced.

If this occurs during childhood, for example, neuro-development is delayed. "Cells behave like countries at war," he says. "When a threat begins, they harden their borders. They don't trust their neighbors.

"One way to look at this related to autism is this: When cells stop talking to each other, children stop talking.

Suramin, a well-known inhibitor of purinergic signaling, first synthesized in 1916 and is commonly used to treat trypanosomiasis or African sleeping sickness, a parasitic disease was used in trial runs on the mice.
 
"The discovery that a single dose of medicine can fundamentally reset metabolism for weeks means that newer and safer drugs might not need to be given chronically," he said.

"Members of this new class of medicines might need to be given only intermittently during sensitive developmental windows to unblock metabolism and permit improved development in response to many kinds of behavioral and occupational therapies, and to natural play."

These recent findings dovetail with the idea that autism is caused by a multitude of interconnected factors: "Twenty percent of the known factors associated with autism are genetic, but most are not.

"It's wrong to think of genes and the environment as separate and independent factors. Genes and environmental factors interact. The net result of this interaction is metabolism."

Researchers found that suramin blocked the extracellular signaling pathway used by ATP and other mitokines in a mouse model of autism spectrum disorder (ASD), ending this cell danger response and related inflammation.

A single dose remained effective in the mice for about five weeks - but then washed out. Suramin also cannot be taken long-term since it can result in anemia and adrenal gland dysfunction.

Cells subsequently began behaving normally and autism-like behaviors and metabolism in the mice were corrected.

Naviaux said these and earlier findings are sufficiently encouraging to soon launch a small phase 1 clinical trial with children who have ASD later this year.

---


Pope Francis: end world hunger through 'Prayer and Action'


Copyright 2015 - Distributed by THE CALIFORNIA NETWORK

Pope Francis Prayer Intentions for February 2016
Universal:
That prisoners, especially the young, may be able to rebuild lives of dignity.
Evangelization: That married people who are separated may find welcome and support in the Christian community.



Comments


More Health

Native American Health Facilities 'Horrifying' Practices: Woman dies on floor of hospital room after staff causes her to overdose Watch

Image of Native American health facilities (not pictured) are so underfunded that poorly trained staff are responsible for serious illnesses and even preventable deaths.

By Kenya Sinclair (CALIFORNIA NETWORK)

During a Senate hearing on Wednesday, several witnesses stepped forward to ask the federal government to fund the struggling Indian Health Service, only to be told that government officials were unable to procure the necessary resources. LOS ANGELES, CA (Catholic ... continue reading


Florida Gorvernor declares state of emergency with Zika virus outbreak Watch

Image of At least nine people have been diagnosed with the Zika Virus in Florida (James Gathany/CDC).

By Kenya Sinclair (CALIFORNIA NETWORK)

Florida Governor Rick Scott declared a state of emergency after nine cases were diagnosed from people who travelled to Zika-dense regions. LOS ANGELES, CA (Catholic Online) - The state of emergency affects Tampa Bay, south and southwest Florida and Santa Rosa County. ... continue reading


Zika virus sexually transmitted in first U.S. case Watch

Image of Zika has been transmitted within the United States.

By Kenya Sinclair (CALIFORNIA NETWORK)

The first known case of the Zika virus being locally acquired in the United States has occured in Dallas, Texas. LOS ANGELES, CA (Catholic Online) - Dallas County health officials confirmed a recent traveler to Venezuela infected their partner after a sexual ... continue reading


Has the origin of the dangerous Zika virus been found? What really started the outbreak? Watch

Image of Women returning from affected areas are being warned to postpone conceive for at least a month in case they have been infected (India News).

By Catholic Online (CALIFORNIA NETWORK)

Most of Latin America - along with the rest of the world, is frantically trying to come to grips with an outbreak of Zika. The mosquito-borne illness usually leaves patients with mild, flu-like symptoms but causes a wide variety of birth defects to expectant ... continue reading


Scientists get permission to carry out horrifying genetic experiments on babies, then destroy them! Watch

Image of The era of designer babies is about to begin. The only cost is the lives of hundreds, possibly thousands of other babies.

By Marshall Connolly, Catholic Online (CALIFORNIA NETWORK)

Scientists in England have been given permission to start genetic experiments with unborn children. The scientists intend to turn off genes in between 30 - 120 unborn children just to see what happens. They claim the experiments will give them new insights that can aid ... continue reading


Is Alzheimer's contagious? Find out NOW! Watch

Image of Doctors continue to investigate whether Alzheimer's can be spread from one person to another (Alamy).

By Kenya Sinclair (CALIFORNIA NETWORK)

Professor John Collinge, the head of neurodegenerative disease at University College London, believes Alzheimer's disease can by transmissible from one person to another during invasive medical procedures -but is he right? LOS ANGELES, CA (Catholic Online) - In a study ... continue reading


Zika virus may halt Olympics as WHO calls emergency meeting for explosive spread of the virus Watch

Image of The Zika virus continues to spread, leading to babies born with smaller-than-normal heads and brain damage (Reuters).

By Kenya Sinclair (CALIFORNIA NETWORK)

Zika virus spreads so quickly and leaves such devastating effects on babies that Rio's Olympics may be cancelled. Meanwhile, the World Health Organization (WHO) has called an emergency meeting following explosive outbreaks. LOS ANGELES, CA (Catholic Online) - According ... continue reading


EVERYTHING you need to know about the dangerous Zika virus Watch

Image of Mothers in Jamaica are being discouraged from becoming pregnant until the Zika crisis has passed (YouTube).

By Anastasia Moloney, Thomson Reuters Foundation

The number of countries and territories in the Americas reporting cases of the mosquito-borne Zika virus rose to 22 on Tuesday, more than double the number a month ago, according to the Pan American Health Organization (PAHO). BOGOTA (Thomson Reuters ... continue reading


It's a hospital not a restaurant! The insane reason why the ACLU is suing a Catholic hospital Watch

Image of Mercy Hospital in Redding, CA has been under fore for refusing to perform a sterilization procedure on a patient.

By Marshall Connolly, Catholic Online (THE CALIFORNIA NETWORK)

Catholic healthcare is back in the news following an ACLU suit against Mercy Hospital in Redding, CA, over whether or not a patient has the right to demand a tubal ligation be performed at the facility following a C-section. A Superior Court judge has already sided ... continue reading


BREAKTHROUGH: Hormone found to extend lifespan by 40 percent Watch

Image of Professor Dixit adds that FGF21 is produced in the liver as an endocrine hormone. Levels of the hormone increase when calories are restricted to allow fats to be burned when glucose levels are low.

By Catholic Online (CALIFORNIA NETWORK)

A recently discovered hormone may provide the key to life extension, as well as improving the immune function. The hormone, as produced by the thymus gland, extends lifespan by 40 percent. LOS ANGELES, CA (Catholic Online) - Some researchers at the Yale School of ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Subscribe to Catholic OnlineYouTube Channel

the FEED
by Catholic Online

Daily Readings

Reading 1, First Kings 8:1-7, 9-13
1 Solomon then summoned the elders of Israel to Jerusalem to bring the ... Read More

Psalm, Psalms 132:6-7, 8-10
6 Listen, we heard of it in Ephrathah, we found it at ... Read More

Gospel, Mark 6:53-56
53 Having made the crossing, they came to land at Gennesaret and moored ... Read More

Saint of the Day

Saint of the Day for February 8th, 2016 Image

St. Jerome Emiliani
February 8: Jerome Emiliani lay chained in the dark dirty ... Read More