Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

6/18/2014 (1 year ago)

Catholic Online (www.catholic.org)

Trials conducted on laboratory mice prove successful; human trial to begin next year

An old drug used in the treatment of sleeping sickness has also temporarily reversed symptoms of autism in mice, researchers have claimed. Researchers say the drug restored normal cellular signaling in a mouse model of autism in animals that were the human biological age equivalent of 30 years old. The results came with a caveat: the effects in the laboratory only lasted for around five weeks.

Suramin, a well-known inhibitor of purinergic signaling, first synthesized in 1916 and is commonly used to treat trypanosomiasis or African sleeping sickness, a parasitic disease was used in trial runs on the mice.

Suramin, a well-known inhibitor of purinergic signaling, first synthesized in 1916 and is commonly used to treat trypanosomiasis or African sleeping sickness, a parasitic disease was used in trial runs on the mice.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

6/18/2014 (1 year ago)

Published in Health

Keywords: Suramin, autism, sleeping sickness, trial tests, mice


LOS ANGELES, CA (Catholic Online) - "Obviously correcting abnormalities in a mouse is a long way from a cure in humans, but we think this approach is a new and fresh way to think about and address the challenge of autism," Robert K. Naviaux at the University of California, San Diego School of Medicine says.

One of the universal symptoms of autism, Naviaux says, is metabolic disturbances.

Get foodinto the hands of needy children -- by going here --

"Cells have a halo of metabolites (small molecules involved in metabolism, the set of chemical processes that maintain life) and nucleotides surrounding them.

"These create a sort of chemical glow that broadcasts the state of health of the cell."

Cells that are threatened or damaged by microbes, such as viruses or bacteria, or by physical forces or by chemicals, such as pollutants, react defensively, a part of the normal immune response. In this case, communications between cells are dramatically reduced.

If this occurs during childhood, for example, neuro-development is delayed. "Cells behave like countries at war," he says. "When a threat begins, they harden their borders. They don't trust their neighbors.

"One way to look at this related to autism is this: When cells stop talking to each other, children stop talking.

Suramin, a well-known inhibitor of purinergic signaling, first synthesized in 1916 and is commonly used to treat trypanosomiasis or African sleeping sickness, a parasitic disease was used in trial runs on the mice.
 
"The discovery that a single dose of medicine can fundamentally reset metabolism for weeks means that newer and safer drugs might not need to be given chronically," he said.

"Members of this new class of medicines might need to be given only intermittently during sensitive developmental windows to unblock metabolism and permit improved development in response to many kinds of behavioral and occupational therapies, and to natural play."

These recent findings dovetail with the idea that autism is caused by a multitude of interconnected factors: "Twenty percent of the known factors associated with autism are genetic, but most are not.

"It's wrong to think of genes and the environment as separate and independent factors. Genes and environmental factors interact. The net result of this interaction is metabolism."

Researchers found that suramin blocked the extracellular signaling pathway used by ATP and other mitokines in a mouse model of autism spectrum disorder (ASD), ending this cell danger response and related inflammation.

A single dose remained effective in the mice for about five weeks - but then washed out. Suramin also cannot be taken long-term since it can result in anemia and adrenal gland dysfunction.

Cells subsequently began behaving normally and autism-like behaviors and metabolism in the mice were corrected.

Naviaux said these and earlier findings are sufficiently encouraging to soon launch a small phase 1 clinical trial with children who have ASD later this year.

---


Pope Francis: end world hunger through 'Prayer and Action'


Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for July 2015
Universal:
That political responsibility may be lived at all levels as a high form of charity.
Evangelization: That, amid social inequalities, Latin American Christians may bear witness to love for the poor and contribute to a more fraternal society.



Comments


More Health

12,000 children may be exposed to HIV and Hepatitis from unsterile surgical equipment at hospital Watch

Image of The Seattle Children's Hospital is under controversy once again.

By Linky C. (NEWS CONSORTIUM)

Seattle's Bellevue clinic Children's Hospital contacts the parents of 12,000 children who might have been exposed to HIV and hepatitis due to un-sterile surgical equipment. MUNTINLUPA CITY, PHILIPPINES (Catholic Online) - Parents of roughly 12,000 children who were ... continue reading


High vaccination rates help protect communities Watch

Image of Pockets of unvaccinated people pose health risks to the immune-compromised population.

By Kenya Sinclair (NEWS CONSORTIUM)

Following the Disneyland Measles outbreak, more and more U.S. parents are vaccinating their children. Despite the increased number of "vaccinators," "anti-vaccers" pose a public health risk. LOS ANGELES, CA (Catholic Online) - The U.S. Centers for Disease Control and ... continue reading


The Universal Flu Vaccine: Researchers are closer to a solution that attacks a different part of the virus Watch

Image of Human immune response to influenza is directed against a protein on the virus called hemagglutinin, and a portion of the protein called the hemagglutinin head, where the majority of the mutations occur.

By Catholic Online (NEWS CONSORTIUM)

It's a universal misery that comes whenever the weather cools or it starts to rain. Influenza begins to settle in to a large part of the population, leading to school and job absences. Researchers now say hat attacking a largely hidden part of the influenza ... continue reading


Grandmother miraculously beats eight different cancers in a row Watch

Image of

By Atarah Haely (NEWS CONSORTIUM)

Many people lose hope while battling cancer and experience even more trauma when they fight the same disease again and again. Despite the constant evolution of technology, there are still risks of developing different forms of cancer at any time. However, one ... continue reading


Hepatitis C finally given approval in United Kingdom after 'inexcusable wait' Watch

Image of Sufferer Pamela Anderson claims she got Hepatitis C from her ex-husband Tommy Lee after they shared tattoo needles.

By Catholic Online (NEWS CONSORTIUM)

It comes as wonderful news for untold thousands of Hepatitis C sufferers, albeit one that came after an "Inexcusable wait." The once-a-day drug sofosbuvir has a 90 percent success rate by patients - and will be available free of charge for patients in the ... continue reading


First human brain grown in laboratory dubbed success, despite scientific doubt Watch

Image of

By Talia Ramos (NEWS CONSORTIUM)

For the first time in the history of science, an almost full-grown human brain was successfully grown outside the body and in a laboratory by a team of researchers. According to The Guardian, the brain is a size comparable to that of a 5-week-old fetus. The brain will ... continue reading


Modern Paleo diet may not be so Paleolithic Watch

Image of

By Atarah Haely (NEWS CONSORTIUM)

Carbohydrates, largely overlooked in the modern Paleo diet, were actually a part of the food group consumed by our hunting-and-gathering forefathers, according to a new study published earlier this month. Although the diet works effectively on some trying to lose ... continue reading


Is coffee really good for you? New research finds coffee may reduce risk of some cancers Watch

Image of

By Hannah Marfil (NEWS CONSORTIUM)

Caffeinated coffee drinkers are at a lower risk of having bowel cancer, as well as dying from the disease and other types, according to recent data. Those who drink four to five mugs of coffee a day were found to cut, by almost a half, the odds of bowel cancer ... continue reading


'Brainy' mice research may lead to effective treatment for Alzheimer's Watch

Image of

By Atarah Haely (NEWS CONSORTIUM)

Genetically altered mice tend to be more intelligent and exhibit less anxiety, according to new research. The discovery is speculated to be a part of a more comprehensive study regarding treatment to diseases like Alzheimer's post-traumatic stress disorder (PTSD) and ... continue reading


Study finds intelligence related to a longer lifespan Watch

Image of

By Talia Ramos (NEWS CONSORTIUM)

A longer lifespan is related to intelligence contributed by the genetic makeup, according to new research. Analyzing three twin studies, a research team found that the link between intelligence and a person's life expectancy is about 95 percent because of genetics, ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Deuteronomy 4:1-2, 6-8
1 'And now, Israel, listen to the laws and customs ... Read More

Psalm, Psalms 15:2-3, 3-4, 4-5
2 Whoever lives blamelessly, who acts uprightly, who ... Read More

Gospel, Mark 7:1-8, 14-15, 21-23
1 The Pharisees and some of the scribes who had come ... Read More

Reading 2, James 1:17-18, 21-22, 27
17 all that is good, all that is perfect, is given us ... Read More

Saint of the Day

Saint of the Day for August 30th, 2015 Image

St. Rumon
August 30: St. Rumon, also known as Ruan, Ronan, and Ruadan, was probably a ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter