Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

1/10/2013 (2 years ago)

Catholic Online (

LY411575 can regenerate regeneration of sensory hair cells

The deaf may hear once again with the daring experimental drug, code named LY411575. The drug has been able to trigger the regeneration of sensory hair cells.

Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.


By Catholic Online (NEWS CONSORTIUM)

Catholic Online (

1/10/2013 (2 years ago)

Published in Health

Keywords: Deafness, sensory hairs, prolonged noise, medication, LY411575

LOS ANGELES, CA (Catholic Online) - Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Often suffered by rock musicians and DJs, this form of deafness is generally assumed to be irreversible.

Scientists have now succeeded in partially restoring hearing to mice that had been deafened by loud noise. While still in the early stages, scientists believe it could lead to effective treatments for acute noise-induced deafness in humans.

The tiny sensory hairs in the cochlea are vital to hearing. Sound vibrations transferred from the eardrum shake the hairs, causing nerve messages to be fired to the brain. Without these hairs, the pathway is blocked and no signals are received by the brain's auditory center.

The new approach involves reprogramming inner ear cells by inhibiting a protein called Notch.

Previous laboratory research had shown that Notch signals help prevent stem cells in the cochlea transforming themselves into new sensory hair cells.

"We show that hair cells can be regenerated from the surrounding cells in the cochlea," Lead researcher Dr Albert Edge, from the Harvard Medical School says.

"These cells, called supporting cells, trans-differentiate into hair cells after inhibition of the Notch signaling pathway, and the new hair cell generation results in a recovery of hearing in the region of the cochlea where the new hair cells appear.

"The significance of this study is that hearing loss is a huge problem affecting 250 million worldwide."

A green fluorescent protein was used to label the newly generated hair cells.

Lost hair cells had been replaced and were working, as attested to by electronic measurements of auditory brainstem responses three months after treatment.

Improvement in hearing was seen over a wide range of frequencies. "The missing hair cells had been replaced by new hair cells after the drug treatment, and analysis of their location allowed us to correlate the improvement in hearing to the areas where the hair cells were replaced," Edge says.

"We're excited about these results because they are a step forward in the biology of regeneration and prove that mammalian hair cells have the capacity to regenerate.

"With more research, we think that regeneration of hair cells opens the door to potential therapeutic applications in deafness."


Pope Francis: end world hunger through 'Prayer and Action'

Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for October 2015
That human trafficking, the modern form of slavery, may be eradicated.
Evangelization: That with a missionary spirit the Christian communities of Asia may announce the Gospel to those who are still awaiting it.


More Health

Baby born with rare medical mystery thrives Watch

Image of Baby Angelito was born with two tubes for a nose.


Baby Angelito was born with two tubes in place of a nose but his doctors are optimistic about his condition.  LOS ANGELES, CA (Catholic Online) - Daily Mail reported the medical mystery as well as Angelito's doctors' belief the infant will soon appear normal.The ... continue reading

20-million-year old flea carrying bubonic plague may be real reason dinosaurs went extinct Watch

Image of The Black Death plague devastated entire populations (Interfoto/Alamy)


Preserved in amber, a 20-million-year-old flea is believed to contain an ancient form of one of the world's deadliest bacteria: Black Death.  LOS ANGELES, CALIFORNIA (Catholic Online) - According to the Journal of Medical Entomology, the fossilized bacteria is ... continue reading

Baby born missing majority of skull miraculously beats the odds, reaches first birthday Watch

Image of


Doctors said that Jaxon Buell only had a few days to live after his birth. The boy was born with a rare condition called the Microhydranencephaly, which left the majority of his skull unable to form. Despite the odds, Jaxon is strong and recently celebrated a milestone ... continue reading

New dangerous cluster of Legionnaires' disease reported in the Bronx Watch

Image of Legionnaires' disease is a lung bacteria that causes flue-like muscle pain, headaches, fevers, drowsiness, chills and in some cases delirium.

By Kenya Sinclair (NEWS CONSORTIUM)

A new cluster of Legionnaires' disease has been reported in the Bronx and is not related to the cluster outbreak in the Bronx earlier this summer that left 12 dead. NEW YORK CITY, NY (Catholic Online) - Fox5ny reported seven cases of Legionnaires' disease in the ... continue reading

Why fidgeting may actually be good for your health Watch

Image of


When you feel like fidgeting, don't worry about whether it's bad for you or not. New research shows that being restless and fidgeting at work can actually be good for your health. HOLLYWOOD, CA  (Catholic Online) - A series of studies showed that long periods of ... continue reading

What you need to know about the developmental process of Influenza Watch

Image of Inflammation associated with infection in the soft palate stimulates the sneezing and coughing. This propels the flu virus out of the mouth enabling it to spread easily.

By Catholic Online (NEWS CONSORTIUM)

Influenza, or "Flu," the respiratory ailment that hits hardest during the colder months, first develops on the roof of the mouth. That's the findings of researchers, who note that flu is then spread through coughs and sneezes. LOS ANGELES, CA (Catholic Online) ... continue reading

Research reveals easy steps to keep cancer away Watch

Image of


The World Cancer Research Fund explained there are ways for people to keep themselves safe from the risk of developing any of the 13 types of cancers in surprisingly easy ways.  MUNTINLUPA, PHILIPPINES (Catholic Online) - According to the Daily Mail, the charity ... continue reading

CURE? Deformed blood vessels may be root cause of Alzheimer's, researchers say Watch

Image of The method by which amyloid plaque builds up in blood vessels remains a mystery, but it needs to be removed via the bloodstream.

By Catholic Online (NEWS CONSORTIUM)

Irish scientists have discovered that Alzheimer's patients have slightly altered blood vessels, which prevents disease-causing plaques from being cleared. Brain tissues of individuals affected by Alzheimer's during their lifetime were then compared results in ... continue reading

'We just wanted God to give us something': Mother left without answers on why teenage daughter's wisdom teeth procedure turned fatal Watch

Image of


Sydney Galleger's family was left with no answers after the 17-year-old went into cardiac arrest during a wisdom tooth extraction.  MUNTINLUPA, PHILIPPINES (Catholic Online) - During a routine oral surgery last June, Galleger's blood pressure spiked and her pulse ... continue reading

'Just get one': Flu vaccine offered with more options Watch

Image of


Flu vaccines can be given through a variety of methods apart from traditional shots, according to The Washington Post.  MUNTINLUPA, PHILIPPINES (Catholic Online) - Trypanophobes -people who fear injections and inoculations- should not shy away from receiving a flu ... continue reading

All Health News


Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Subscribe to Catholic OnlineYouTube Channel

Saint of the Day

Saint of the Day for October 4th, 2015 Image

St. Francis of Assisi
October 4: Founder of the Franciscan Order, born at Assisi in Umbria, in ... Read More