Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

1/10/2013 (2 years ago)

Catholic Online (www.catholic.org)

LY411575 can regenerate regeneration of sensory hair cells

The deaf may hear once again with the daring experimental drug, code named LY411575. The drug has been able to trigger the regeneration of sensory hair cells.

Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

1/10/2013 (2 years ago)

Published in Health

Keywords: Deafness, sensory hairs, prolonged noise, medication, LY411575


LOS ANGELES, CA (Catholic Online) - Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Often suffered by rock musicians and DJs, this form of deafness is generally assumed to be irreversible.

Scientists have now succeeded in partially restoring hearing to mice that had been deafened by loud noise. While still in the early stages, scientists believe it could lead to effective treatments for acute noise-induced deafness in humans.

The tiny sensory hairs in the cochlea are vital to hearing. Sound vibrations transferred from the eardrum shake the hairs, causing nerve messages to be fired to the brain. Without these hairs, the pathway is blocked and no signals are received by the brain's auditory center.

The new approach involves reprogramming inner ear cells by inhibiting a protein called Notch.

Previous laboratory research had shown that Notch signals help prevent stem cells in the cochlea transforming themselves into new sensory hair cells.

"We show that hair cells can be regenerated from the surrounding cells in the cochlea," Lead researcher Dr Albert Edge, from the Harvard Medical School says.

"These cells, called supporting cells, trans-differentiate into hair cells after inhibition of the Notch signaling pathway, and the new hair cell generation results in a recovery of hearing in the region of the cochlea where the new hair cells appear.

"The significance of this study is that hearing loss is a huge problem affecting 250 million worldwide."

A green fluorescent protein was used to label the newly generated hair cells.

Lost hair cells had been replaced and were working, as attested to by electronic measurements of auditory brainstem responses three months after treatment.

Improvement in hearing was seen over a wide range of frequencies. "The missing hair cells had been replaced by new hair cells after the drug treatment, and analysis of their location allowed us to correlate the improvement in hearing to the areas where the hair cells were replaced," Edge says.

"We're excited about these results because they are a step forward in the biology of regeneration and prove that mammalian hair cells have the capacity to regenerate.

"With more research, we think that regeneration of hair cells opens the door to potential therapeutic applications in deafness."

---


Pope Francis: end world hunger through 'Prayer and Action'


Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for May 2015
Universal:
That, rejecting the culture of indifference, we may care for our neighbours who suffer, especially the sick and the poor.
Evangelization: That Mary's intercession may help Christians in secularized cultures be ready to proclaim Jesus.


Rosaries, Crosses, Prayer Cards and more... by Catholic Shopping .com


Comments


More Health

Revolutionary! Robotic arm controlled by thought provides breakthrough for paralyzed Watch

Image of

By Catholic Online (NEWS CONSORTIUM)

An exciting new breakthrough in robotics may now enable the paralyzed to command helpmates with everyday activity. The breakthrough came in form of 34-year-old Erik Sorto, paralyzed from the neck down after being shot in the back 13 years ago. Thanks to a ... continue reading


Ancient Chinese plant 'thunder god vine' studied as miracle drug for obesity Watch

Image of In developed nations, where food is inexpensive and plentiful, obesity has been an ongoing problem. Obesity causes heart disease, diabetes and increases the risk for heart attack and stroke.

By Catholic Online (NEWS CONSORTIUM)

A traditional Chinese medicine known as "thunder god vine" is being heralded by some scientists as the new miracle drug in the war against obesity. Scientists in an article published in the medical journal Cell last week said an extract made from the plant ... continue reading


Brain reset: Scientists uncover unusual way to get rid of brain disorders Watch

Image of

By Atarah Haely (NEWS CONSORTIUM)

By implanting special cells that emit GABA into the brains of adult mice scientists found a way to cure certain brain disorders, like lazy eye. Initially an almost impossible endeavor, the experiment led a team of scientists to a way to reset the brain and basically ... continue reading


Health in the United States: Which cities are the healthiest? Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

The American College of Sports Medicine has recently released their 2015 American Fitness Index, naming the top three fittest and the least fit cities in the entire United States. MUNTINLUPA, PHILIPPINES (Catholic Online) -  Among the thousands of cities surveyed ... continue reading


Nebraska orders STATE OF EMERGENCY over H5N2 avian flu virus Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

A type of avian flu, and unfortunately the most lethal to hit the United States, has posed several concerns for farmers and scientists. So far, the H5N2 strain of the bird flu virus has already killed 15,000 turkeys in Minnesota alone. Now, over 33 million birds in 16 ... continue reading


Why a handshake just might save your life Watch

Image of Handshakes may be able to determine your risk for heart disease or other illnesses.

By Matt Waterson (NEWS CONSORTIUM)

Are you worried about a heart attack or stroke? Well there may be an easy way to tell if you are at greater risk for either of these diseases, are near death or seriously ill, and you don't need anything more than a hand and a partner. LOS ANGELES, CA (Catholic ... continue reading


Are you afraid of needles? Scientist believes he found way to reduce injection pain Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

A lot of people, the young and old alike, are really frightened of getting injections, even just the thought of it. The good news is that scientists have discovered a simple answer. MUNTINLUPA, PHILIPPINES (Catholic Online) - Spanish scientists believe that holding ... continue reading


Woman gives shocking birth to baby born with bladder outside of body Watch

Image of

By Hannah Raissa Marfil (NEWS CONSORTIUM)

Born with a rare congenital defect, Baby Lila underwent a unique surgery, shortly after she was born with her bladder outside the body. This defect was detected when the doctor couldn't find her bladder in a sonogram conducted during the 22-week prenatal appointment. ... continue reading


What do healthy people eat for breakfast? 11 healthy breakfast choices from dietitians and experts Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

What we eat in the mornings have an effect on our energy levels throughout the day. Here, registered dietitians, personal trainers, health editors and nutritionists, suggest healthy breakfasts for a healthy morning start, with some help from BuzzFeed. MUNTINLUPA, ... continue reading


NOT-SO HAPPY PILLS: Half a million patients die every year from psychiatric drugs Watch

Image of Professor Peter Gotzsche, research director at Denmark's Nordic Cochrane Center says the use of most antidepressants and dementia drugs could be discontinued without harm.

By Catholic Online (NEWS CONSORTIUM)

A Danish scientist has come forward to proclaim that mood enhancers, "happy pills" and other psychiatric drugs are frequently deadly - killing half a million people a year. Furthermore, he says that these medications are usually ineffective - not producing the ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Sirach 17:19-27
19 Their actions are all as plain as the sun to him, ... Read More

Psalm, Psalms 32:1-2, 5, 6, 7
1 [Of David Poem] How blessed are those whose offence ... Read More

Gospel, Mark 10:17-27
17 He was setting out on a journey when a man ran up, ... Read More

Saint of the Day

Saint of the Day for May 25th, 2015 Image

St. Mary Magdalene de Pazzi
May 25: It would be easy to concentrate on the mystical experiences God ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter