Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

1/10/2013 (2 years ago)

Catholic Online (www.catholic.org)

LY411575 can regenerate regeneration of sensory hair cells

The deaf may hear once again with the daring experimental drug, code named LY411575. The drug has been able to trigger the regeneration of sensory hair cells.

Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

1/10/2013 (2 years ago)

Published in Health

Keywords: Deafness, sensory hairs, prolonged noise, medication, LY411575


LOS ANGELES, CA (Catholic Online) - Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Often suffered by rock musicians and DJs, this form of deafness is generally assumed to be irreversible.

Scientists have now succeeded in partially restoring hearing to mice that had been deafened by loud noise. While still in the early stages, scientists believe it could lead to effective treatments for acute noise-induced deafness in humans.

The tiny sensory hairs in the cochlea are vital to hearing. Sound vibrations transferred from the eardrum shake the hairs, causing nerve messages to be fired to the brain. Without these hairs, the pathway is blocked and no signals are received by the brain's auditory center.

The new approach involves reprogramming inner ear cells by inhibiting a protein called Notch.

Previous laboratory research had shown that Notch signals help prevent stem cells in the cochlea transforming themselves into new sensory hair cells.

"We show that hair cells can be regenerated from the surrounding cells in the cochlea," Lead researcher Dr Albert Edge, from the Harvard Medical School says.

"These cells, called supporting cells, trans-differentiate into hair cells after inhibition of the Notch signaling pathway, and the new hair cell generation results in a recovery of hearing in the region of the cochlea where the new hair cells appear.

"The significance of this study is that hearing loss is a huge problem affecting 250 million worldwide."

A green fluorescent protein was used to label the newly generated hair cells.

Lost hair cells had been replaced and were working, as attested to by electronic measurements of auditory brainstem responses three months after treatment.

Improvement in hearing was seen over a wide range of frequencies. "The missing hair cells had been replaced by new hair cells after the drug treatment, and analysis of their location allowed us to correlate the improvement in hearing to the areas where the hair cells were replaced," Edge says.

"We're excited about these results because they are a step forward in the biology of regeneration and prove that mammalian hair cells have the capacity to regenerate.

"With more research, we think that regeneration of hair cells opens the door to potential therapeutic applications in deafness."

---


Pope Francis: end world hunger through 'Prayer and Action'


Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for June 2015
Universal:
That immigrants and refugees may find welcome and respect in the countries to which they come.
Evangelization: That the personal encounter with Jesus may arouse in many young people the desire to offer their own lives in priesthood or consecrated life.


Rosaries, Crosses, Prayer Cards and more... by Catholic Shopping .com


Comments


More Health

Are you at risk for skin cancer? Too much citrus may lead to melanoma Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

Consuming large amounts of orange juice or grapefruit may increase the risk of the most dangerous type of skin cancer, melanoma, according to recent studies. MUNTINLUPA, PHILIPPINES (Catholic Online) - Dr. Walter Willett of the Harvard School of Public Health, who ... continue reading


PUBLIC HEALTH VICTORY: Cuba becomes first nation to eliminate mother-to-child HIV, syphilis Watch

Image of Antiretroviral treatment to prevent mother-to-child-transmission of HIV, authorities remind the public, is not 100 per cent effective. A small number of cases are allowed to persist, despite the certification.

By Catholic Online (NEWS CONSORTIUM)

Heralded as one of the "greatest public health achievements possible," World Health Organization director-general Margaret Chan has declared that the Caribbean nation of Cuba has become the first nation to eliminate the transmission of HIV and syphilis from ... continue reading


Health experts warn on animal diseases used as biological weapons Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

The World Health Organization (WHO), animal health and national defense officers announced on June 30 the need for a wider international cooperation to sidestep the spread of animal diseases that could potentially be utilized as deadly biological weapons.  ... continue reading


Lazy lifestyles pose dangerous and deadly threat to today's generation Watch

Image of Laziness can lead to problems with being overweight.

By Nikky Andres (NEWS CONSORTIUM)

You might not be entirely aware, but according to the World Health Organization, physical inactivity is now the fourth most notorious global killer. In fact, the impact of physical inactivity has been claimed as the reason for more fatalities than the collective effect ... continue reading


5 wonderful facts about sunscreen that you didn't know Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

The need to use sunscreen is something emphasized everyday, not only by dermatologists but also by the beauty industry, media, etc. It's basically everywhere. It is not an alien fact to us that using sunscreen religiously will help us combat premature aging, the risk ... continue reading


Is getting plastic surgery a sin against God? Watch

Image of Plastic surgery is considered a simple medical procedure nowadays but remains as an intriguing aspect for the Catholic Church.

By Linky C. (NEWS CONSORTIUM)

Plastic surgery may seem to be a common medical procedure for several individuals around the globe, but the Catholic Church still has different points of views when it comes to changing the naturally bestowed beauty from God. Some medical practitioners, on the other ... continue reading


'Swimming pool eyes' are not because of chlorine... but because of urine Watch

Image of Swimmers that use the pool for their toilet causes the urine to react with chlorine. This in turn creates a chemical compound that hurts the eyes.

By Catholic Online (NEWS CONSORTIUM)

In a sage bit of advice that has a double meaning - you may not want to "go" to a public swimming pool after you learn this disgusting fact. If you emerge from the pool with red, stinging, sensitive eyes, it is not because of the chlorine... it is because of ... continue reading


Recording reveals anesthesiologist's shocking verbal abuse against unconscious patient Watch

Image of An anesthesiologist [not pictured] is caught make rude comments about patient.

By Atarah Haely (NEWS CONSORTIUM)

Instead of simply recording his doctor's post-operation instructions, as intended, a Virginian man accidentally recorded the anesthesiologist's verbal onslaught against him while he was asleep. Concealing his identity, the patient filed a lawsuit, including the doctor ... continue reading


Eating 'Fitness Snacks' may not be the healthy alternative for staying fit Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

We often hear the term "fitness food" or see products that are marketed as a healthy and guilt-free alternatives to chocolates and chips, or a way to fight cravings and hunger pangs. But could these "fitness foods" really be the key to keeping oneself healthy and fit? ... continue reading


Have you been exposed to this common, 'cancer causing' chemical? Watch

Image of A chemical commonly used in herbicides may cause cancer in those exposed to it, though early evidence is not conclusive.

By Matt Waterson (NEWS CONSORTIUM)

A chemical in a common herbicide widely used in farm work may potentially pose a threat to humans who are exposed to it, a new report from a World Health Organization (WHO) research unit has found. LOS ANGELES, CA (Catholic Online) - The herbicide known as ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Genesis 28:10-22
10 Jacob left Beersheba and set out for ... Read More

Psalm, Psalms 91:1-2, 3-4, 14-15
1 You who live in the secret place of Elyon, spend ... Read More

Gospel, Matthew 9:18-26
18 While he was speaking to them, suddenly one of the ... Read More

Saint of the Day

Saint of the Day for July 6th, 2015 Image

St. Maria Goretti
July 6: Born in Corinaldo, Ancona, Italy, on October 16 1890; her ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter