Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

1/10/2013 (2 years ago)

Catholic Online (www.catholic.org)

LY411575 can regenerate regeneration of sensory hair cells

The deaf may hear once again with the daring experimental drug, code named LY411575. The drug has been able to trigger the regeneration of sensory hair cells.

Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

1/10/2013 (2 years ago)

Published in Health

Keywords: Deafness, sensory hairs, prolonged noise, medication, LY411575


LOS ANGELES, CA (Catholic Online) - Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Often suffered by rock musicians and DJs, this form of deafness is generally assumed to be irreversible.

Scientists have now succeeded in partially restoring hearing to mice that had been deafened by loud noise. While still in the early stages, scientists believe it could lead to effective treatments for acute noise-induced deafness in humans.

The tiny sensory hairs in the cochlea are vital to hearing. Sound vibrations transferred from the eardrum shake the hairs, causing nerve messages to be fired to the brain. Without these hairs, the pathway is blocked and no signals are received by the brain's auditory center.

The new approach involves reprogramming inner ear cells by inhibiting a protein called Notch.

Previous laboratory research had shown that Notch signals help prevent stem cells in the cochlea transforming themselves into new sensory hair cells.

"We show that hair cells can be regenerated from the surrounding cells in the cochlea," Lead researcher Dr Albert Edge, from the Harvard Medical School says.

"These cells, called supporting cells, trans-differentiate into hair cells after inhibition of the Notch signaling pathway, and the new hair cell generation results in a recovery of hearing in the region of the cochlea where the new hair cells appear.

"The significance of this study is that hearing loss is a huge problem affecting 250 million worldwide."

A green fluorescent protein was used to label the newly generated hair cells.

Lost hair cells had been replaced and were working, as attested to by electronic measurements of auditory brainstem responses three months after treatment.

Improvement in hearing was seen over a wide range of frequencies. "The missing hair cells had been replaced by new hair cells after the drug treatment, and analysis of their location allowed us to correlate the improvement in hearing to the areas where the hair cells were replaced," Edge says.

"We're excited about these results because they are a step forward in the biology of regeneration and prove that mammalian hair cells have the capacity to regenerate.

"With more research, we think that regeneration of hair cells opens the door to potential therapeutic applications in deafness."

---


Pope Francis: end world hunger through 'Prayer and Action'


Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for March 2015
Universal:
Scientists: That those involved in scientific research may serve the well-being of the whole human person.
Evangelization: Contribution of women: That the unique contribution of women to the life of the Church may be recognized always.



Comments


More Health

'Smoking is even deadlier than we thought' New study gives alarming statistics for smokers Watch

Image of The Centers for Disease Control and Prevention estimates about 42.1 million Americans smoke cigarettes, a habit which remains the number one cause of preventable disease and death in the U.S.

By Catholic Online (NEWS CONSORTIUM)

Smoking cigars and cigarettes has long been the source of various cancers, such as lung and mouth cancers, and has been linked to heart attack, stroke and high blood pressure. New research from Australian medical examiners have now discovered that the practice ... continue reading


Paging Dr. Frankenstein! Human head transplant possible in just two years Watch

Image of Dr. Sergio Canavero said he would expect the patient to be able to move and feel their face when they awoke, they would speak with the same voice. They would be able to walk within a year.

By Catholic Online (NEWS CONSORTIUM)

The procedure would be beneficial to humankind - and help those who are stricken with devastating disease. When we learn of the process, however, the first thing to pop into our heads is hunchbacked assistants and green-faced monsters. A human heads transplant ... continue reading


Shocking 'medical miracle' birth startles doctors and parents Watch

Image of (Cedars-Sinai Medical Center in Los Angeles)

By Abigail James (NEWS CONSORTIUM)

Now dubbed a "medical miracle," the birth of Silas Philips took doctors by surprise when he was born still inside his amniotic sac. Silas' birth miracle is extremely rare, only 1 in 80,000 births are similar to his. LOS ANGELES, CA (Catholic Online) - When his mother ... continue reading


New pill dramatically cuts risk for AIDS transmission in homosexual men Watch

Image of Some 545 HIV-negative gay men, who were sexually active and had recently had unprotected sex, were recruited to the study.

By Catholic Online (NEWS CONSORTIUM)

A daily pill, pre-exposure prophylaxis, or PrEP has been found to dramatically cut a person's risk of contracting HIV. Following a trial in the United Kingdom, advocates say the drug must be made available as soon as possible. LOS ANGELES, CA (Catholic Online) ... continue reading


AT RISK: Formula-fed babies at risk for ingesting ARSENIC Watch

Image of While arsenic in home tap water was a source of the naturally occurring chemical, poisonous in large doses, the formula itself was a contributing factor as well.

By Catholic Online (NEWS CONSORTIUM)

Breastfeeding has long been deemed the healthiest nursing option for newborns. A new study from Dartmouth College bears this out: According to researchers, arsenic levels were more than seven times higher in formula-fed babies than in breastfed ones. LOS ... continue reading


Unbelievable: Secret to success may lie in your sleeping habits Watch

Image of New studies show the most successful people receive little sleep at night.

By Abigail James (NEWS CONSORTIUM)

Traditional research advises people between 18-64 years old get seven to nine hours of sleep for a healthy lifestyle. New studies are showing that some of the most successful and smartest people in the world rarely even get half of that amount of sleep a night. LOS ... continue reading


Closing door and throwing away the key: HIV vaccine proves SUCCESSFUL in monkeys Watch

Image of Given the drug, the test monkeys were able to fend off high, repeated doses of the simian version of the disease.

By Catholic Online (NEWS CONSORTIUM)

Comparing it to locking up an intruder and throwing away the key, scientists now say they have created an anti-HIV drug so powerful that it could work as a vaccine. The test trials have proven to be highly successful in Macaque monkeys.  LOS ANGELES, CA ... continue reading


Women are at risk: Dementia affects more women than men, quickly becoming number one killer Watch

Image of

By Abigail James (NEWS CONSORTIUM)

500,000 women are affected by dementia. This is compared to the 350,000 men who are afflicted. Dementia is quickly surpassing breast cancer or heart disease; it is becoming the newest disease that favors women. LOS ANGELES, CA (Catholic Online) - Not only is dementia ... continue reading


Unable to feel pain, rare medical condition haunts man's life with horrifying injuries Watch

Image of Undergoing a series of tests throughout his lifetime, it was not until 2011 that Steve Pete was given the genetic tests confirmed he and his brother Chris had genetic mutations of the SCN9A gene.

By Catholic Online (NEWS CONSORTIUM)

Steve Pete's parents knew something was wrong with their child when he chewed part of his tongue off while he was a baby. Pete suffers from a rare condition known as congenital analgesia, where he is unable to feel pain. Unable to detect physical discomfort, ... continue reading


Don't throw away those glasses yet! Lasik eye surgery found imperfect, even dangerous Watch

Image of The results of bad eye laser surgery include the necessitating of several glasses for both near and far-sighted vision, dry eyes and blurring of light sources at night.

By Catholic Online (NEWS CONSORTIUM)

Lasik eye surgery, where vision defects are cured with lasers, has a high success rate. However, anyone who undergoes the procedure must carefully weigh the risks. Those for whom the procedure fails must wear several glasses afterwards and suffer ailments. The ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Jeremiah 18:18-20
18 'Come on,' they said, 'let us concoct a plot ... Read More

Psalm, Psalms 31:5-6, 14, 15-16
5 to your hands I commit my spirit, by you have I ... Read More

Gospel, Matthew 20:17-28
17 Jesus was going up to Jerusalem, and on the road ... Read More

Saint of the Day

Saint of the Day for March 4th, 2015 Image

St. Casimir
March 4: Casimir grew up in a world where his life was not his own. As a ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter