Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

1/10/2013 (1 year ago)

Catholic Online (www.catholic.org)

LY411575 can regenerate regeneration of sensory hair cells

The deaf may hear once again with the daring experimental drug, code named LY411575. The drug has been able to trigger the regeneration of sensory hair cells.

Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

1/10/2013 (1 year ago)

Published in Health

Keywords: Deafness, sensory hairs, prolonged noise, medication, LY411575


LOS ANGELES, CA (Catholic Online) - Previously, it has not been possible to restore the cells once they have been lost due to external factors. Such factors include prolonged loud noise exposure, infection and toxic drugs.

Often suffered by rock musicians and DJs, this form of deafness is generally assumed to be irreversible.

Scientists have now succeeded in partially restoring hearing to mice that had been deafened by loud noise. While still in the early stages, scientists believe it could lead to effective treatments for acute noise-induced deafness in humans.

The tiny sensory hairs in the cochlea are vital to hearing. Sound vibrations transferred from the eardrum shake the hairs, causing nerve messages to be fired to the brain. Without these hairs, the pathway is blocked and no signals are received by the brain's auditory center.

The new approach involves reprogramming inner ear cells by inhibiting a protein called Notch.

Previous laboratory research had shown that Notch signals help prevent stem cells in the cochlea transforming themselves into new sensory hair cells.

"We show that hair cells can be regenerated from the surrounding cells in the cochlea," Lead researcher Dr Albert Edge, from the Harvard Medical School says.

"These cells, called supporting cells, trans-differentiate into hair cells after inhibition of the Notch signaling pathway, and the new hair cell generation results in a recovery of hearing in the region of the cochlea where the new hair cells appear.

"The significance of this study is that hearing loss is a huge problem affecting 250 million worldwide."

A green fluorescent protein was used to label the newly generated hair cells.

Lost hair cells had been replaced and were working, as attested to by electronic measurements of auditory brainstem responses three months after treatment.

Improvement in hearing was seen over a wide range of frequencies. "The missing hair cells had been replaced by new hair cells after the drug treatment, and analysis of their location allowed us to correlate the improvement in hearing to the areas where the hair cells were replaced," Edge says.

"We're excited about these results because they are a step forward in the biology of regeneration and prove that mammalian hair cells have the capacity to regenerate.

"With more research, we think that regeneration of hair cells opens the door to potential therapeutic applications in deafness."

---


Pope Francis: end world hunger through 'Prayer and Action'


2014 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for November 2014
Lonely people:
That all who suffer loneliness may experience the closeness of God and the support of others.
Mentors of seminarians and religious: That young seminarians and religious may have wise and well-formed mentors.



Comments


More Health

GROSS! This was in his brain for four years! Watch

Image of A type of parasitic tapeworm, just a little over 0.3 inches in length, burrowed its way through the brain of a British man for four years.

By Catholic Online (NEWS CONSORTIUM)

In what has to be one of the most bizarre cases in recent medical history, a series of brain scans have been made which charts the path of a tiny parasitic tapeworm as it burrows its way through the brain of a British man. LOS ANGELES, CA (Catholic Online) - This ... continue reading


Obesity: It isn't just deadly, but each year it costs the globe TWO TRILLION! Watch

Image of Obesity is the third largest economic burden on the world, just $.1 trillion behind the costs of smoking and war and terrorism.

By Catholic Online (NEWS CONSORTIUM)

It should come as no surprise to anyone that terrorism and war hurt the global economy. What is incredible is that just behind them in terms of actual cost is smoking, and obesity. LOS ANGELES, CA (Catholic Online) - A new report from the economic consulting firm ... continue reading


Creation of John Paul II Medical Research Institute

By Alan B. Moy, MD

The Catholic Church has a long-standing history in health care, education and medical research. The Church was the first during the Middle Ages to create the university system and medical centers. Some of the early scientists were clergymen like Gregor Mendel, who was ... continue reading


Welcome to the horrifying future where women are used and abortion rampant Watch

Image of In the future, according to one dire prediction, babies will come from test tubes and sex will be purely for recreation.

By Catholic Online (NEWS CONSORTIUM)

The professor and chemist who invented the birth control pill has now claimed that advances in IVF will render the pill obsolete allowing people to plan pregnancies and engage in sex for recreational purposes only. LOS ANGELES, CA (Catholic Online) - Prof. Carl ... continue reading


Eat healthy, exercise and take statins - and live to be 120 years old Watch

Image of A

By Catholic Online (NEWS CONSORTIUM)

While immortality still remains out of reach by scientific standards, some scientists now say they have worked out how we could make it to 120. Exercising more, eating healthy and taking statins they claim are key to slowing the aging process. LOS ANGELES, CA ... continue reading


Dignity Health loses moral compass, settles overcharge scandal for $37 million Watch

Image of Catholic facilities, built and supported by Catholics, should remain Catholic.

By Catholic Online (NEWS CONSORTIUM)

The San Francisco-based Dignity Health hospital chain has agreed to pay a $37 million settlement to clear up allegations that they overcharged patients between 2006 and 2010. LOS ANGELES, CA (Catholic Online) - Dignity Health, a chain of 13 hospitals that was built by ... continue reading


'Elite controllers' claim that they can spontaneously 'cure' HIV Watch

Image of AIDS/HIV remains a scourge throughout the African continent and homosexual men in urban areas.

By Catholic Online (NEWS CONSORTIUM)

It's another claim made by researchers about a disease that continues to devastate the world. Scientists say they have uncovered the genetic mechanism which appeared to have led two HIV-infected men to experience a "spontaneous cure - and that the discovery ... continue reading


Sierra Leone sees Ebola cases 'spreading quickly' Watch

Image of There have been 2,413 Ebola deaths in Liberia, 1,510 in Sierra Leone, 1,018 in Guinea and eight in Nigeria.

By Catholic Online (NEWS CONSORTIUM)

While in other parts of West Africa, new Ebola cases appear to be tapering off, new cases continue to rise "frighteningly quickly" in areas of Sierra Leone. The international campaign group the Africa Governance Initiative, or AGI found that in rural parts of ... continue reading


'Hyper-connected' brain created by popular hallucinogen 'Magic Mushrooms' Watch

Image of Some magic mushroom users have reported tasting colors, seeing noises or feeling smells.

By Catholic Online (NEWS CONSORTIUM)

A popular, if illegal natural hallucinogen, "magic mushrooms" inspired the art and music of the hippie counter-cultural generation. Scientists now claim they are closer to understanding why magic mushrooms cause people to have such intense creative and even ... continue reading


Convenient and easy! Why your next trip to the dentist could prove a lifesaver Watch

Image of A new study out of UCLA has shown that genetic molecules that can signal an early warning for certain diseases can actually be found in saliva as well as blood.

By Catholic Online (NEWS CONSORTIUM)

Soon, dentists may be able to test for diseases such as cancer, dementia, Alzheimer's, type 2 diabetes or even auto-immune diseases, a new report from the University of California Los Angeles, has revealed. LOS ANGELES, CA (Catholic Online) - Dr. David Wong, the ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Ezekiel 34:11-12, 15-17
11 "For the Lord Yahweh says this: Look, I myself ... Read More

Psalm, Psalms 23:1-2, 2-3, 5, 6
1 [Psalm Of David] Yahweh is my shepherd, I lack ... Read More

Gospel, Matthew 25:31-46
31 'When the Son of man comes in his glory, escorted ... Read More

Reading 2, First Corinthians 15:20-26, 28
20 In fact, however, Christ has been raised from the ... Read More

Saint of the Day

Saint of the Day for November 23rd, 2014 Image

Bl. Miguel Pro
November 23: Born on January 13, 1891 in Guadalupe, Mexico, Miguel Agustin ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter