Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

1/10/2013 (2 years ago)

Catholic Online (www.catholic.org)

Scientist report remarkable success with laboratory mice

An exciting new drug could quickly become the first oral medication that could helpĀ the paralyzed to walk again. Scientists have reported remarkable success mice who previously had no movement in their lower limbs to walk again with "well-coordinated steps" and even to replicate swimming motions.

The small molecule in the study was tested for its ability to prevent the death of cells called oligodendrocytes, which surround and protect axons, long projections of a nerve cell, by wrapping them in a myelin sheath that protects the fibers.

The small molecule in the study was tested for its ability to prevent the death of cells called oligodendrocytes, which surround and protect axons, long projections of a nerve cell, by wrapping them in a myelin sheath that protects the fibers.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

1/10/2013 (2 years ago)

Published in Health

Keywords: Paralysis, drug, experiemnt, lab animals, oligodendrocytes


LOS ANGELES, CA (Catholic online) - The experimental medication also didn't increase pain in the mice and showed no toxic effects. The medication also efficiently crossed the blood brain barrier, which protects the central nervous system from potentially harmful chemicals carried around in the rest of the bloodstream.

"This is a first to have a drug that can be taken orally to produce functional improvement with no toxicity in a rodent model," Professor Sung Ok Yoon of Ohio State University Columbus says.

"So far, in the spinal cord injury field with rodent models, effective treatments have included more than one therapy, often involving invasive means. Here, with a single agent, we were able to obtain functional improvement."

The small molecule in the study was tested for its ability to prevent the death of cells called oligodendrocytes, which surround and protect axons, long projections of a nerve cell, by wrapping them in a myelin sheath that protects the fibers.

The drug then preserved oligodendrocytes by inhibiting the activation of a protein called p75. Yoon's lab previously found p75 is linked to the death of these specialized cells after a spinal cord injury. When they die, axons that are supported by them degenerate.

"Because we know oligodendrocytes continue to die for a long period of time after an injury, we took the approach that if we could put a brake on that cell death, we could prevent continued degeneration of axons.

"Many researchers in the field are focusing on regeneration of neurons, but we specifically targeted a different type of cell because it allows a relatively long therapeutic window."

The current treatment for humans, methylprednisolone must be administered within eight but not after 24 hours after the injury to be effective at all.

An estimated 1.3 million people in the United States are living with spinal cord injuries, experiencing paralysis and complications that include bladder, bowel and sexual dysfunction and chronic pain.

Called LM11A-31, the experimental drug was developed by Professor Frank Longo, of Stanford University, California.

The researchers gave three different oral doses of LM11A-31 in addition to a placebo, to different groups of mice starting four hours after injury and then twice daily for a 42 day experimental period.

The scientists analyzed the compound's effectiveness at improving limb movement and preventing myelin loss.

The spinal cord injuries in mice mimicked those caused in humans by the application of extensive force and pressure, resulting in loss of hind limb and bladder function and difficulty in walking and swimming.

The researchers determined the mice did not experience more pain than the placebo group at all the doses tested, suggesting LM11A-31 does not worsen nerve pain after spinal cord injury.

---


Pope Francis: end world hunger through 'Prayer and Action'


Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for June 2015
Universal:
That immigrants and refugees may find welcome and respect in the countries to which they come.
Evangelization: That the personal encounter with Jesus may arouse in many young people the desire to offer their own lives in priesthood or consecrated life.


Rosaries, Crosses, Prayer Cards and more... by Catholic Shopping .com


Comments


More Health

Are you at risk for skin cancer? Too much citrus may lead to melanoma Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

Consuming large amounts of orange juice or grapefruit may increase the risk of the most dangerous type of skin cancer, melanoma, according to recent studies. MUNTINLUPA, PHILIPPINES (Catholic Online) - Dr. Walter Willett of the Harvard School of Public Health, who ... continue reading


PUBLIC HEALTH VICTORY: Cuba becomes first nation to eliminate mother-to-child HIV, syphilis Watch

Image of Antiretroviral treatment to prevent mother-to-child-transmission of HIV, authorities remind the public, is not 100 per cent effective. A small number of cases are allowed to persist, despite the certification.

By Catholic Online (NEWS CONSORTIUM)

Heralded as one of the "greatest public health achievements possible," World Health Organization director-general Margaret Chan has declared that the Caribbean nation of Cuba has become the first nation to eliminate the transmission of HIV and syphilis from ... continue reading


Health experts warn on animal diseases used as biological weapons Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

The World Health Organization (WHO), animal health and national defense officers announced on June 30 the need for a wider international cooperation to sidestep the spread of animal diseases that could potentially be utilized as deadly biological weapons.  ... continue reading


Lazy lifestyles pose dangerous and deadly threat to today's generation Watch

Image of Laziness can lead to problems with being overweight.

By Nikky Andres (NEWS CONSORTIUM)

You might not be entirely aware, but according to the World Health Organization, physical inactivity is now the fourth most notorious global killer. In fact, the impact of physical inactivity has been claimed as the reason for more fatalities than the collective effect ... continue reading


5 wonderful facts about sunscreen that you didn't know Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

The need to use sunscreen is something emphasized everyday, not only by dermatologists but also by the beauty industry, media, etc. It's basically everywhere. It is not an alien fact to us that using sunscreen religiously will help us combat premature aging, the risk ... continue reading


Is getting plastic surgery a sin against God? Watch

Image of Plastic surgery is considered a simple medical procedure nowadays but remains as an intriguing aspect for the Catholic Church.

By Linky C. (NEWS CONSORTIUM)

Plastic surgery may seem to be a common medical procedure for several individuals around the globe, but the Catholic Church still has different points of views when it comes to changing the naturally bestowed beauty from God. Some medical practitioners, on the other ... continue reading


'Swimming pool eyes' are not because of chlorine... but because of urine Watch

Image of Swimmers that use the pool for their toilet causes the urine to react with chlorine. This in turn creates a chemical compound that hurts the eyes.

By Catholic Online (NEWS CONSORTIUM)

In a sage bit of advice that has a double meaning - you may not want to "go" to a public swimming pool after you learn this disgusting fact. If you emerge from the pool with red, stinging, sensitive eyes, it is not because of the chlorine... it is because of ... continue reading


Recording reveals anesthesiologist's shocking verbal abuse against unconscious patient Watch

Image of An anesthesiologist [not pictured] is caught make rude comments about patient.

By Atarah Haely (NEWS CONSORTIUM)

Instead of simply recording his doctor's post-operation instructions, as intended, a Virginian man accidentally recorded the anesthesiologist's verbal onslaught against him while he was asleep. Concealing his identity, the patient filed a lawsuit, including the doctor ... continue reading


Eating 'Fitness Snacks' may not be the healthy alternative for staying fit Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

We often hear the term "fitness food" or see products that are marketed as a healthy and guilt-free alternatives to chocolates and chips, or a way to fight cravings and hunger pangs. But could these "fitness foods" really be the key to keeping oneself healthy and fit? ... continue reading


Have you been exposed to this common, 'cancer causing' chemical? Watch

Image of A chemical commonly used in herbicides may cause cancer in those exposed to it, though early evidence is not conclusive.

By Matt Waterson (NEWS CONSORTIUM)

A chemical in a common herbicide widely used in farm work may potentially pose a threat to humans who are exposed to it, a new report from a World Health Organization (WHO) research unit has found. LOS ANGELES, CA (Catholic Online) - The herbicide known as ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Genesis 22:1-19
1 It happened some time later that God put Abraham to ... Read More

Psalm, Psalms 115:1-2, 3-4, 5-6, 8-9
1 Not to us, Yahweh, not to us, but to your name give ... Read More

Gospel, Matthew 9:1-8
1 He got back in the boat, crossed the water and came ... Read More

Saint of the Day

Saint of the Day for July 2nd, 2015 Image

St. Bernardino Realino
July 2: St. Bernardino Realino was born into a noble family of Capri, ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter