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By Catholic Online (NEWS CONSORTIUM)

5/16/2011 (3 years ago)

Catholic Online (www.catholic.org)

Gene called KLF14 linked to type 2 diabetes and cholesterol levels

A gene linked to diabetes and cholesterol has been declared by scientists as a "master switch" that controls other genes found in fat in the body. Researchers say that by studying and targeting the gene, identified as KLF14 should help in the search for treatments for obesity-related diseases.

Obesity-related diseases already account for nearly 10 percent of medical spending in the United States, an estimated $147 billion a year. Type 2 diabetes, usually linked to poor diet and lack of exercise, is also reaching epidemic levels worldwide as rates of obesity rise.

Obesity-related diseases already account for nearly 10 percent of medical spending in the United States, an estimated $147 billion a year. Type 2 diabetes, usually linked to poor diet and lack of exercise, is also reaching epidemic levels worldwide as rates of obesity rise.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

5/16/2011 (3 years ago)

Published in Health

Keywords: KLF14, obesity, diabetes, glucose, gene research


LOS ANGELES, CA (Catholic Online) - As reported in the journal Nature Genetics, the British researchers say that since fat plays an important role in peoples' susceptibility to metabolic diseases like obesity, heart disease and diabetes, the regulating gene could be target for drugs to treat such illnesses. "This is the first major study that shows how small changes in one master regulator gene can cause a cascade of other metabolic effects in other genes," Tim Spector of King's College London, who led the study, says. Obesity has become the worldwide scourge of the 21st century. More than half a billion people -- one in 10 adults worldwide, are obese. The numbers have doubled since the 1980s, as even the poorer nations - where starvation remains a real concern; have become effected by the obesity epidemic. Obesity-related diseases already account for nearly 10 percent of medical spending in the United States, an estimated $147 billion a year. Type 2 diabetes, usually linked to poor diet and lack of exercise, is also reaching epidemic levels worldwide as rates of obesity rise. Researchers analyzed more than 20,000 genes in fat samples taken from under the skin of 800 British female twin volunteers and found a link between the KLF14 gene and the levels of many other distant genes found in fat tissue, showing that KLF14 acts as a master switch to control these genes. The findings were confirmed with 600 fat samples from a separate group of people from Iceland. In a report of their study, the researchers explained that other genes found to be controlled by KLF14 are linked to a range of metabolic traits, including body mass index, obesity, cholesterol, insulin and glucose levels. "KLF14 seems to act as a master switch controlling processes that connect changes in the behavior of subcutaneous fat to disturbances in muscle and liver that contribute to diabetes and other conditions," Mark McCarthy from Britain's Oxford University says. "We are working hard...to understand these processes and how we can use this information to improve treatment of these conditions."

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Pope Francis: end world hunger through 'Prayer and Action'


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Pope Francis Prayer Intentions for July 2014
Sports:
That sports may always be occasions of human fraternity and growth.
Lay Missionaries: That the Holy Spirit may support the work of the laity who proclaim the Gospel in the poorest countries.



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