Prefecture Apostolic in Brazil, bounded on the south by a line running westwards from the confluence of the Rio Negro and Rio Branco along the watershed of the Rio Negro to Colombia, separating the new prefecture from those of Teffé and Upper Solimões, and the See of Amazones (from which it was separated by a Decree of the Sacred Congregation of the Consistory, 19 Oct., 1910), on the west by Colombia, on the north by Colombia and Venezuela, on the east by the territory of Rio Branco. The white population is small, and confined to the few villages along the banks of the Rio Negro. As early as 1658 a Jesuit Father, Francisco Gonsales, established a mission among the natives of the Upper Rio Negro, and traces of the work of the Jesuit missionaries still exist in the scattered villages. Two years later a Carmelite, Father Theodosius, evangelized the Tucumaos. The Franciscans labored among the Indians from 1870 and had seven stations on the Rio Uaupés (Tariana Indians), four on the Rio Tikié (Toccana Indians), and one on the Rio Papuri (Macu Indians), but on the fall of the empire most of the missions were abandoned, though some of them were re-established later.

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