Stem Cell Options
Bioethics Council Ponders 4 Proposals
WASHINGTON, D.C., MAY 23, 2005 (Zenit) - On May 10 the President's Council on Bioethics presented a report looking on alternative sources of stem cells. Entitled "Alternative Sources of Human Pluripotent Stem Cells," the report explains that human embryonic stem cells are of great interest because of their pluripotency, that is, their capacity to give rise to the various specialized cells of the body. Nevertheless, many people reject the use of such cells, given that they cannot be obtained without destroying embryos.
The council, established by President George Bush in 2001 to advise him on bioethical issues, looked at other ways of obtaining stem cells and proposed four possibilities: stem cells from dead embryos; from living embryos, by non-destructive biopsy; from bioengineered embryolike artifacts; and from reprogrammed adult somatic cells.
The report stipulates that it is only a preliminary study, noting that more research is needed regarding the scientific viability of the alternatives. In addition, "more discussion is surely required on some of the ethical issues we have identified."
The first proposal makes an analogy with the use of human cadavers for biomedical research or as sources of organs. Similarly, stem cells from early in-vitro fertilization embryos that have spontaneously died could be used for the benefit of others. The concept of death for the early-stage human embryo would be the irreversible loss of the capacity for continued cellular division and growth.
In most cases this cessation of development is associated with chromosomal abnormalities in the developing embryos. But some of them have cells that appear normal, and that may turn out to be a source of embryonic stem cells. The proposal contemplates using already-frozen IVF embryos, which would be thawed and examined for viability, so as to avoid putting other embryos at risk.
In general, this looks ethically acceptable, the Council on Bioethics states, insofar as it is based on the use of cells from embryos that die naturally. However, the report adds, "the final ethical assessment of this proposal will depend very much on exactly how it is implemented."
The report does, however, raise some doubts. Concerning the definition of death, the problem is that, as the harvested cells are to serve as a source of stem cells, it is not feasible to wait for the death of each and every cell before declaring the embryo dead and, hence, eligible for use in research. Therefore, the question arises as to whether the embryo is really dead. Identifying the criteria for death of an organism at such an early stage of life as this is not easy, the council warns.
Extraction from the living
In the second proposal, stem cells are to be derived by means of a biopsy of an early human embryo. Already, the study notes, extractions are made from living IVF embryos to conduct pre-implantation genetic diagnosis.
Here, the council observes, the major ethical issue concerns the question of possible harm to the still-living embryo whose cells are removed. Moreover, since the extraction is not being performed for the good of the embryo, it might be hard to justify the procedure.
Another objection arises from the possibility that some may want to use this method, not only on embryos to be transferred to a woman, but also on "spare" embryos not selected for implantation. Because of the still-unknown risk of harm due to a biopsy, the bioethics council notes that some have suggested that the procedure can be ethically done only on an embryo that is not going to become a child. This in turn leads to objections from those who consider such a utilitarian treatment of embryos to be morally unacceptable, the report notes.
The third approach involves several proposals that contemplate engineering "biological artifacts." So far, these projects are untested, even on animals. One of these proposals, presented to the bioethics council last December, involves a variation on techniques used in cloning.
In cloning, a somatic cell nucleus is introduced into an oocyte (egg cell) whose own nucleus has been removed. The proposal involves modifying the somatic cell nucleus before its transfer, in such a way that the result, while being a source of pluripotent stem cells, would lack the essential attributes and capacities of a human embryo.
In favor of this proposal is the argument that no embryo creation or destruction is involved. But, the council comments, critics of the idea are worried that "the proposed biological artifact has, from the beginning, a built-in genetic defect that prevents it from developing normally." So rather than being the production of a non-human entity, it may involve "the deliberate creation of a doomed or disabled human embryo."
A further ethical objection arises that this technique, like cloning, requires a large supply of egg cells. Obtaining these requires hormonal stimulation and superovulation in the women who would be donating or selling their eggs. In addition to the medical risks, there are concerns over the exploitation of poor women, and the creation of markets in human reproductive tissues.
Other concerns arise from setting a precedent in manipulating human tissues. "Once we start down the road of deliberately engineering artificial entities with some human properties, it is not obvious how bright ethical boundaries between the acceptable and the unacceptable can be drawn," notes the report.
The fourth proposal considered by the bioethics council involves reprogramming somatic cells so as to restore to them the pluripotency of embryonic stem cells. This does not involve using embryos, and the report affirms, should not be ethically objectionable. The only possible problem would arise if the reprogramming went beyond the point of achieving pluripotency to the point of yielding a totipotent cell -- in effect, a cloned human zygote.
The main difficulty with this proposal, the council continues, is scientific. Research into the question of this modification of cells is at a preliminary stage, and it is too early to know whether it can succeed.
The council concludes that the second and third proposals are ethically unacceptable. The first, using cells from dead embryos, it judges to be acceptable, though the procedure raises serious ethical questions. The last proposal is found to be ethically unproblematic, if it ever becomes scientifically possible.
Council members split over the ethical judgments. In a final section of the report, Michael Gazzaniga declared his support for the use of human embryos, and even cloning, to provide stem cells.
A joint statement by Robert George, Mary Ann Glendon and Alfonso Gómez-Lobo supports efforts "to identify means of obtaining human pluripotent stem cells for biomedical research that do not involve killing or harming human embryos and do not invite the exploitation of women to obtain ova."
Their declaration supported the fourth proposal as the best long-term solution. But they added that further research and ethical reflection on all the alternatives are welcome.
So far, the Catholic Church has not reacted officially to the council's report. The U.S. bishops' conference did, however, publish on May 16 the results of an opinion poll that found 52% opposed to federal funding of embryonic stem cell research.
"It is always wrong for government to promote the destruction of innocent human life," said Richard Doerflinger, deputy director of the bishops' Secretariat for Pro-Life Activities. The debate will continue as the U.S. House of Representatives now considers a bill to provide government funding for embryonic stem-cell research.
http://www.catholic.org CA, US
Catholic Online - Publisher, 661 869-1000
Stem Cell, US, embryonic, Human, Research, Bioethics
More Catholic PRWire
Showing 1 - 50 of 4,718
A Recession Antidote
Monaco & The Vatican: Monaco's Grace Kelly Exhibit to Rome--A Review of Monegasque-Holy See Diplomatic History
Dna. Maria St. Catherine Sharpe, t.o.s.m., T.O.SS.T.
A Royal Betrayal: Catholic Monaco Liberalizes Abortion
Dna. Maria St.Catherine De Grace Sharpe, t.o.s.m., T.O.SS.T.
Embrace every moment as sacred time
Mary Regina Morrell
Letting go is simple wisdom with divine potential
Mary Regina Morrell
Father Lombardi's Address on Catholic Media
Pope's Words to Pontifical Latin American College
Prelate: Genetics Needs a Conscience
State Aid for Catholic Schools: Help or Hindrance?
Scorsese Planning Movie on Japanese Martyrs
2 Nuns Kidnapped in Kenya Set Free
Holy See-Israel Negotiation Moves Forward
Franchising to Evangelize
Catholics Decry Anti-Christianity in Israel
Pope and Gordon Brown Meet About Development Aid
Pontiff Backs Latin America's Continental Mission
Cardinal Warns Against Anti-Catholic Education
Three words to a deeper faith
Relections for Lent 2009
Wisdom lies beyond the surface of life
Mary Regina Morrell
World Food Program Director on Lent
Pope's Lenten Message for 2009
Keeping a Lid on Permissiveness
Glimpse of Me
The 3 stages of life
Sex and the Married Woman
A Catholic Woman Returns to the Church
Modernity & Morality
Just a Minute
Catholic identity ... triumphant reemergence!
Edging God Out
Burying a St. Joseph Statue
George Bush Speaks on Papal Visit
Sometimes moving forward means moving the canoe
Mary Regina Morrell
Easter... A Way of Life
Papal initiative...peace and harmony!
Proclaim the mysteries of the Resurrection!
Jerusalem Patriarch's Easter Message
Good Friday Sermon of Father Cantalamessa
Papal Address at the End of the Way of the Cross
Cardinal Zen's Meditations for Via Crucis
Interview With Vatican Aide on Jewish-Catholic Relations
Pope Benedict XVI On the Easter Triduum
by Catholic Online
- St. Fabian: Saint of the Day for Saturday, January 20, 2018
- 5 Things You Need To Know About 'Offering A Mass' For A Loved One
- Cardinal Dolan asks the faithful to pray against 'powers of darkness' ...
- Most Americans want abortion restricted, if not outlawed
- Science is transforming the pro-life debate for the better HD Video
- Daily Readings for Saturday, January 20, 2018
- Daily Reading for Monday, January 22nd, 2018 HD Video
- morning prayer
- Saint Elizabeth
- St. Augustine
- Saint Anne
- st agnes
- saint monica
- saint catherine
- Saint Lucy
- saint clare
- saint rose
- st rose of lima
- immaculate conception
- st augustine
- st monica
- saint of the day
- St. Elizabeth
- john bosco
- st catherine
- st. cecilia
- st. paul
- Daily Reading for Tuesday, January 23rd, 2018 HD
- Daily Reading for Sunday, January 21st, 2018 HD
- Jobless claims are down - what does that mean for workers? HD
- Daily Reading for Saturday, January 20th, 2018 HD
Learn about Catholic world
Inform - Inspire - Ignite
Catholic Online Saints
Your saints explained
Catholic Online Prayers
Prayers for every need
Catholic Online Bible
Complete bible online
Catholic Online News
Your news Catholic eye
Today's bible reading
Products and services we offer
Catholic Online Shopping
Catholic medals, gifts & books
The California Network
Inspiring streaming service
Learn the Catholic way
Teacher lesson plans & resources
Support Free Education
Tax deductible support Free education