Stem cell model for bipolar disorder may lead to new treatments
By Catholic Online (NEWS CONSORTIUM)
3/27/2014 (3 years ago)
Catholic Online (www.catholic.org)
Bipolar disorder is one of the ore common examples of mental illness. Those who suffer from bipolar disorder suffer drastic mood swings - from ecstatic happiness to the depths of despair. It's not yet known what causes it. Researchers from the University of Michigan Medical School have now created the first stem cell model for bipolar disorder. They hope that the model will uncover the origins of the condition and open the door to new treatments.
Bipolar disorder is one of the ore common examples of mental illness. Those who suffer from bipolar disorder suffer drastic mood swings - from ecstatic happiness to the depths of despair.
LOS ANGELES, CA (Catholic Online) - Investigators obtained skin samples from people with bipolar disorder along with skin samples from individuals without the condition.
Exposing small samples of skin cells to carefully controlled conditions, the researchers turned them into induced pluripotent stem cells, or iPSCs. These are stem cells that have the potential to be turned into any other type of cell. The team then turned the iPSCs into neurons.
Researchers then measured gene expression of the iPSCs and then re-evaluated gene expression once the stem cells became neurons. The team found significant differences between the stem cells taken from bipolar patients from those without the condition.
Stem cell lines were made from the skin of bipolar patients. Researchers found that the neurons from bipolar patients expressed more genes for membrane receptors and ion channels than the neurons from non-bipolar patients. This was particularly true for genes for receptors and channels involved in sending and receiving calcium signals between cells.
As calcium signals play a significant role in neuron development and function, the investigators say their findings suggest that genetic differences in early brain development may contribute to the development of bipolar and other mental health conditions later in life.
Researchers exposed the neurons to lithium, which is a chemical that bipolar patients often use to regulate their mood, signaling that patterns had changed.
Researchers explain that lithium changes how calcium signals are sent and received. These new cell lines will allow them to determine the mechanisms behind this in cells specific to bipolar patients.
Bipolar disorders affects approximately 5.7 million adults in the US every year.
Bipolar disorder is currently treated with various medications, such as mood stabilizers, antidepressants and antipsychotics. Not all bipolar patients respond to them in the same way and many are left with uncontrolled symptoms.
"We're very excited about these findings" study author Melvin McInnis, of the Department of Psychiatry at the University of Michigan Medical School, says. He notes that this stem cell model could lead to personalized treatment for bipolar disorder.
He does qualify the recent findings. "But we're only just beginning to understand what we can do with these cells to help answer the many unanswered questions in bipolar disorder's origins and treatment.
"For instance, we can now envision being able to test new drug candidates in these cells, to screen possible medications proactively instead of having to discover them fortuitously."
Copyright 2018 - Distributed by THE CALIFORNIA NETWORK
Pope Francis Prayer Intentions for FEBRUARY 2018
Say 'No' to Corruption. That those who have material, political or spiritual power may resist any lure of corruption.
Could your cleaning supplies be making you sick? A new study suggests they are, after finding that women who use household cleaning ... continue reading
Surely depression is an unwelcome visitor, one that can easily wreak havoc in the lives of those within its reach. However, it is not ... continue reading
As the deadly flu season remains far from over, controversy over whether to get the vaccine or not lingers on everyone's minds. LOS ... continue reading
The mind-body connection is a strong one, especially when there has been significant childhood trauma. This connection is one that often ... continue reading
Several Stanford researchers may have found a potential cure for cancer with a simple injection now being referred to as a "cancer ... continue reading
by Catholic Online
- 'Living Lent': Monday of the Second Week of Lent - Day 13
- 'Living Lent': Tuesday of the Second Week of Lent - Day 14
- The Biblical Seal of Isaiah has been found! HD Video
- 'Living Lent': Sunday of the Second Week of Lent - Day 12
- St. Tarasius: Saint of the Day for Sunday, February 25, 2018
- Daily Readings for Sunday, February 25, 2018
- Daily Reading for Sunday, February 25th, 2018 HD Video
- The Tragic Reason Mass Shootings Happen, and it's NOT the guns HD
- Daily Reading for Saturday, February 24th, 2018 HD
- Spiritual Warfare and the Help of Angels HD
- St. Lawrence, Deacon and Martyr HD
Learn about Catholic world
Inform - Inspire - Ignite
Catholic Online Saints
Your saints explained
Catholic Online Prayers
Prayers for every need
Catholic Online Bible
Complete bible online
Catholic Online News
Your news Catholic eye
Today's bible reading
Products and services we offer
Catholic Online Shopping
Catholic medals, gifts & books
The California Network
Inspiring streaming service
Learn the Catholic way
Teacher lesson plans & resources
Support Free Education
Tax deductible support Free education