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By Catholic Online (NEWS CONSORTIUM)

2/18/2014 (1 year ago)

Catholic Online (www.catholic.org)

Women in the future could be medicated in lieu of biopsy, surgery

Lopinavir, a drug used in the treatment of HIV, could be used to treat cervical cancer. Lopinavir has been shown to kill-off the human papilloma virus, or HPV that leads to cervical cancer.

The trial took place at the Kenyatta National Hospital (KNH) in Nairobi, Kenya. The couple, Ian and Lynne Hampson, from the University of Manchester, joined Dr. Innocent Orora Maranga at KNH, to examine 40 women with low-grade and high-grade stage pre-cancerous disease of the cervix.

The trial took place at the Kenyatta National Hospital (KNH) in Nairobi, Kenya. The couple, Ian and Lynne Hampson, from the University of Manchester, joined Dr. Innocent Orora Maranga at KNH, to examine 40 women with low-grade and high-grade stage pre-cancerous disease of the cervix.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

2/18/2014 (1 year ago)

Published in Health

Keywords: Cervical cancer, lopinivar, HIV


LOS ANGELES, CA (Catholic Online) - A husband and wife team from the University of Manchester have successfully treated women with lopinavir. They found that it wiped out pre-cancerous cells in 90 percent of trial participants -- with no side effects.

The findings, to be presented at two conferences later this month, have been welcomed by scientists. It is hoped that in lieu of biopsy and surgery, women can be prescribed the medication and use it at home. 

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The trial took place at the Kenyatta National Hospital (KNH) in Nairobi, Kenya. The couple, Ian and Lynne Hampson, from the University of Manchester, joined Dr. Innocent Orora Maranga at KNH, to examine 40 women with low-grade and high-grade stage pre-cancerous disease of the cervix.

The antiviral drug lopinavir is used orally to treat HIV. In the experiments, lopinavir was applied directly to the cervix as a pessary in the trial.

Women in the trials were treated with one capsule of the antiviral drug twice a day for two weeks. Repeat cervical smears showed a marked improvement within one month of the treatment and after three months, there was a "definite response."

Out of 23 women initially diagnosed with high-grade disease, 19 returned to normal. Overall, there was a positive response in 91 percent of patients.

Photographic images of the cervix before and after treatment showed clear regression of the cervical lesions and no adverse reactions were reported.
 
"For an early stage clinical trial the results have exceeded our expectations. We have seen women with high-grade disease revert to a normal healthy cervix within a comparatively short period of time," Dr. Ian Hampson said.

"We are convinced that further optimization of the dose and treatment period will improve the efficacy still further.

"It is our hope that this treatment has the potential to revolutionize the management of this disease most particularly in developing nations such as Kenya."

Cervical cancer is caused by infection with and is more than five times more prevalent in East Africa than the United Kingdom.

"Current HPV Vaccines are prophylactics aimed at preventing the disease rather than curing or treating symptoms," Lampson says.

"Other than surgery, as yet there is no effective treatment for either HPV infection or the pre-cancerous lesion it causes, which is why these results are so exciting."

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