Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

4/15/2013 (2 years ago)

Catholic Online (www.catholic.org)

Discovery may be effective on patients who are resistant to or intolerant of statins

Trapping the destructive protein where it couldn't harm receptors responsible for removing cholesterol is a goal by many researchers. While statins have proved successful in the maintenance of "bad cholesterol," many patients have received no demonstrable benefit from their use. Scientists, led by Professor David Ginsburg of the University of Michigan's Howard Hughes Medical Institute have now inhibited the action of a gene responsible for transporting a protein that interferes with the ability of the liver to remove cholesterol from the blood in mice.

Initial studies of anti-PCSK9 therapies in humans have shown that eliminating PCSK9 can lower cholesterol dramatically as well as work with statins like Lipitor to lower it even further.

Initial studies of anti-PCSK9 therapies in humans have shown that eliminating PCSK9 can lower cholesterol dramatically as well as work with statins like Lipitor to lower it even further.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

4/15/2013 (2 years ago)

Published in Health

Keywords: Cholesterol, statins, technique, research, Lipitor


LOS ANGELES, CA (Catholic Online) - Scientists found that mice with an inactive SEC24A gene could develop normally. The mice's plasma cholesterol levels were reduced by 45 percent due to vesicles from liver cells were not able to recruit and transport a critical regulator of blood cholesterol levels called proprotein convertase subtilisin/kexin type 9 (PCSK9).

PCSK9, a secretory protein that destroys the liver cells' receptors of low-density lipoprotein, or LDL, the so-called "bad cholesterol" and prevents the cells from removing the LDL.

"Inhibiting SEC24A or PCSK9 may be an alternative to statins, and could work together with statins to produce even greater effects," Dr. Xiao-Wei Chen from the Howard Hughes Medical Institute says. "Also, they might be effective on patients who are resistant to or intolerant of statins."

Initial studies of anti-PCSK9 therapies in humans have shown that eliminating PCSK9 can lower cholesterol dramatically as well as work with statins like Lipitor to lower it even further. The new study points to a new area for study: rather than inhibiting PCSK9 itself, perhaps future therapies could block the transport mechanism that allows the destructive protein to reach the LDL receptors.

Professor Ginsburg's team focused on a specialized type of vesicle packaged by the Coat Protein Complex II, which regulates the metabolism of cholesterol. These vesicles selectively transport cargo proteins including PCSK9.

Without those LDL receptors (LDLR), liver cells are not able to remove LDLs from the bloodstream, so protecting the LDLR from PCSK9 would allow the receptors to continue to remove cholesterol.

"Without SEC24A, much of the PCSK9 couldn't make its way out of the cells to destroy the LDLR, which then clears cholesterol from the blood," a researcher said.

 "We have no reason at this point to expect that this strategy will be any better than anti-PCSK9 therapy for treating high cholesterol, but it would be another alternative approach, and it's hard to predict which drugs will work the best and be the safest until we actually try them out in people," Ginsburg said.

---


Pope Francis: end world hunger through 'Prayer and Action'


Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for June 2015
Universal:
That immigrants and refugees may find welcome and respect in the countries to which they come.
Evangelization: That the personal encounter with Jesus may arouse in many young people the desire to offer their own lives in priesthood or consecrated life.


Rosaries, Crosses, Prayer Cards and more... by Catholic Shopping .com


Comments


More Health

Are you at risk for skin cancer? Too much citrus may lead to melanoma Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

Consuming large amounts of orange juice or grapefruit may increase the risk of the most dangerous type of skin cancer, melanoma, according to recent studies. MUNTINLUPA, PHILIPPINES (Catholic Online) - Dr. Walter Willett of the Harvard School of Public Health, who ... continue reading


PUBLIC HEALTH VICTORY: Cuba becomes first nation to eliminate mother-to-child HIV, syphilis Watch

Image of Antiretroviral treatment to prevent mother-to-child-transmission of HIV, authorities remind the public, is not 100 per cent effective. A small number of cases are allowed to persist, despite the certification.

By Catholic Online (NEWS CONSORTIUM)

Heralded as one of the "greatest public health achievements possible," World Health Organization director-general Margaret Chan has declared that the Caribbean nation of Cuba has become the first nation to eliminate the transmission of HIV and syphilis from ... continue reading


Health experts warn on animal diseases used as biological weapons Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

The World Health Organization (WHO), animal health and national defense officers announced on June 30 the need for a wider international cooperation to sidestep the spread of animal diseases that could potentially be utilized as deadly biological weapons.  ... continue reading


Lazy lifestyles pose dangerous and deadly threat to today's generation Watch

Image of Laziness can lead to problems with being overweight.

By Nikky Andres (NEWS CONSORTIUM)

You might not be entirely aware, but according to the World Health Organization, physical inactivity is now the fourth most notorious global killer. In fact, the impact of physical inactivity has been claimed as the reason for more fatalities than the collective effect ... continue reading


5 wonderful facts about sunscreen that you didn't know Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

The need to use sunscreen is something emphasized everyday, not only by dermatologists but also by the beauty industry, media, etc. It's basically everywhere. It is not an alien fact to us that using sunscreen religiously will help us combat premature aging, the risk ... continue reading


Is getting plastic surgery a sin against God? Watch

Image of Plastic surgery is considered a simple medical procedure nowadays but remains as an intriguing aspect for the Catholic Church.

By Linky C. (NEWS CONSORTIUM)

Plastic surgery may seem to be a common medical procedure for several individuals around the globe, but the Catholic Church still has different points of views when it comes to changing the naturally bestowed beauty from God. Some medical practitioners, on the other ... continue reading


'Swimming pool eyes' are not because of chlorine... but because of urine Watch

Image of Swimmers that use the pool for their toilet causes the urine to react with chlorine. This in turn creates a chemical compound that hurts the eyes.

By Catholic Online (NEWS CONSORTIUM)

In a sage bit of advice that has a double meaning - you may not want to "go" to a public swimming pool after you learn this disgusting fact. If you emerge from the pool with red, stinging, sensitive eyes, it is not because of the chlorine... it is because of ... continue reading


Recording reveals anesthesiologist's shocking verbal abuse against unconscious patient Watch

Image of An anesthesiologist [not pictured] is caught make rude comments about patient.

By Atarah Haely (NEWS CONSORTIUM)

Instead of simply recording his doctor's post-operation instructions, as intended, a Virginian man accidentally recorded the anesthesiologist's verbal onslaught against him while he was asleep. Concealing his identity, the patient filed a lawsuit, including the doctor ... continue reading


Eating 'Fitness Snacks' may not be the healthy alternative for staying fit Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

We often hear the term "fitness food" or see products that are marketed as a healthy and guilt-free alternatives to chocolates and chips, or a way to fight cravings and hunger pangs. But could these "fitness foods" really be the key to keeping oneself healthy and fit? ... continue reading


Have you been exposed to this common, 'cancer causing' chemical? Watch

Image of A chemical commonly used in herbicides may cause cancer in those exposed to it, though early evidence is not conclusive.

By Matt Waterson (NEWS CONSORTIUM)

A chemical in a common herbicide widely used in farm work may potentially pose a threat to humans who are exposed to it, a new report from a World Health Organization (WHO) research unit has found. LOS ANGELES, CA (Catholic Online) - The herbicide known as ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Genesis 27:1-5, 15-29
1 When Isaac had grown old, and his eyes were so weak ... Read More

Psalm, Psalms 135:1-2, 3-4, 5-6
1 Alleluia! Praise the name of Yahweh, you who serve ... Read More

Gospel, Matthew 9:14-17
14 Then John's disciples came to him and said, 'Why ... Read More

Saint of the Day

Saint of the Day for July 4th, 2015 Image

St. Elizabeth of Portugal
July 4: Elizabeth was a Spanish princess who was given in marriage to ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter