Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

4/15/2013 (3 years ago)

Catholic Online (www.catholic.org)

Discovery may be effective on patients who are resistant to or intolerant of statins

Trapping the destructive protein where it couldn't harm receptors responsible for removing cholesterol is a goal by many researchers. While statins have proved successful in the maintenance of "bad cholesterol," many patients have received no demonstrable benefit from their use. Scientists, led by Professor David Ginsburg of the University of Michigan's Howard Hughes Medical Institute have now inhibited the action of a gene responsible for transporting a protein that interferes with the ability of the liver to remove cholesterol from the blood in mice.

Initial studies of anti-PCSK9 therapies in humans have shown that eliminating PCSK9 can lower cholesterol dramatically as well as work with statins like Lipitor to lower it even further.

Initial studies of anti-PCSK9 therapies in humans have shown that eliminating PCSK9 can lower cholesterol dramatically as well as work with statins like Lipitor to lower it even further.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

4/15/2013 (3 years ago)

Published in Health

Keywords: Cholesterol, statins, technique, research, Lipitor


LOS ANGELES, CA (Catholic Online) - Scientists found that mice with an inactive SEC24A gene could develop normally. The mice's plasma cholesterol levels were reduced by 45 percent due to vesicles from liver cells were not able to recruit and transport a critical regulator of blood cholesterol levels called proprotein convertase subtilisin/kexin type 9 (PCSK9).

PCSK9, a secretory protein that destroys the liver cells' receptors of low-density lipoprotein, or LDL, the so-called "bad cholesterol" and prevents the cells from removing the LDL.

"Inhibiting SEC24A or PCSK9 may be an alternative to statins, and could work together with statins to produce even greater effects," Dr. Xiao-Wei Chen from the Howard Hughes Medical Institute says. "Also, they might be effective on patients who are resistant to or intolerant of statins."

Initial studies of anti-PCSK9 therapies in humans have shown that eliminating PCSK9 can lower cholesterol dramatically as well as work with statins like Lipitor to lower it even further. The new study points to a new area for study: rather than inhibiting PCSK9 itself, perhaps future therapies could block the transport mechanism that allows the destructive protein to reach the LDL receptors.

Professor Ginsburg's team focused on a specialized type of vesicle packaged by the Coat Protein Complex II, which regulates the metabolism of cholesterol. These vesicles selectively transport cargo proteins including PCSK9.

Without those LDL receptors (LDLR), liver cells are not able to remove LDLs from the bloodstream, so protecting the LDLR from PCSK9 would allow the receptors to continue to remove cholesterol.

"Without SEC24A, much of the PCSK9 couldn't make its way out of the cells to destroy the LDLR, which then clears cholesterol from the blood," a researcher said.

 "We have no reason at this point to expect that this strategy will be any better than anti-PCSK9 therapy for treating high cholesterol, but it would be another alternative approach, and it's hard to predict which drugs will work the best and be the safest until we actually try them out in people," Ginsburg said.

---


Pope Francis: end world hunger through 'Prayer and Action'


Copyright 2016 - Distributed by THE CALIFORNIA NETWORK

Pope Francis Prayer Intentions for May 2016
Universal:
Respect for Women: That in every country of the world, women may be honored and respected and that their essential contribution to society may be highly esteemed.
Evangelization: Holy Rosary: That families, communities, and groups may pray the Holy Rosary for evangelization and peace.



Comments


More Health

HORRIFYING: Abortion mill calls 911 to save baby after botched abortion Watch

Image of A baby is a human being, even before it is born. There should be no question of its right to life.

By Marshall Connolly (CALIFORNIA NETWORK)

A chilling recording has been released on a 911 call from an abortion mill, requesting emergency services for a baby who survived an abortion. The call was placed earlier this year and left people wondering about the fate of the baby. It also raised the issue of the ... continue reading


WHAT IS GOING ON? Only 5 percent of terminal cancer patients fully understand their prognosis Watch

Image of A new study reveals 95 percent of cancer patients fail to fully understand their prognosis.

By Kenya Sinclair (CALIFORNIA NETWORK)

According to a new study on terminally-ill cancer patients, only five percent of patients fully understood their prognosis, which raises several questions. LOS ANGELES, CA (Catholic Online) - Researchers from Memorial Sloan Kettering Cancer Center, Cornell University ... continue reading


TERRIFYING: Real life Dr. Moreau, hard at work developing human-animal hybrids Watch

Image of Pigs like these could soon grow human organs, even brains.

By Marshall Connolly (CALIFORNIA NETWORK)

A real life Dr. Moreau is hard at work, trying to create animals that grow organs for humans that can be transplanted without any danger of rejection. His work mixes human and animal genes, giving rise to a host of ethical concerns. LOS ANGELES, CA (California Network) ... continue reading


Scientists find evidence of life after death! But for some people, it's very bad news... Watch

Image of For half of the people, dying wasn't a pleasant experience.

By David Drudge (CALIFORNIA NETWORK)

A British study suggests that life after death is an actual phenomenon, and there's evidence to prove it. A study involving more than 2,000 people found that life continues even after the heart stops beating. LOS ANGELES, CA (California Network) - A major study ... continue reading


The key to a long, healthy life? Go to church! Watch

Image of One study revealed church attendance makes for a healthier life (Shutterstock).

By Kenya Sinclair (CALIFORNIA NETWORK)

Researchers looking at data of nearly 75,000 middle-aged women nurses in the United States and discovered something wonderful! LOS ANGELES, CA (Catholic Online) - The Nurses' Health Study, had the thousands of participants answer several questions, including whether ... continue reading


New TB treatment offers hope Watch

Image of WHO considers new TB treatment (Philippe Schneider/World Vision).

By Kenya Sinclair (CALIFORNIA NETWORK)

The World Health Organization (WHO) recently released an announcement that can change lives around the world. LOS ANGELES, CA (Catholic Online) - According to WHO's website, a new test and treatment for tuberculosis has been created and is currently under review.The ... continue reading


7-year-old boy who grew hair out for cancer patients tragically diagnosed with aggressive stage 4 cancer Watch

Image of

By Abigail James (CALIFORNIA NETWORK)

In a "cruel twist of fate," seven-year-old Vinny Desautels, who grew his hair out for two years to donate to cancer patients, has now been diagnosed with an aggressive stage 4 cancer. LOS ANGELES, CA (Catholic Online) - Despite being constantly teased by his peers, ... continue reading


Scientists play God in controversial move to revive the dead Watch

Image of Can scientists bring the dead back to life (Pinterest)?

By Kenya Sinclair (CALIFORNIA NETWORK)

It sounds like the plot to a science fiction story but scientists are about to attempt to bring twenty certified dead people back to life. LOS ANGELES, CA (Catholic Online) - Bioquark Inc., a biotech company, has received ethical permission to bring twenty brain-dead ... continue reading


Vatican teams up with United States to fight cancer Watch

Image of Pope Francis and Joe Biden talk cancer research at Vatican.

By Kenya Sinclair (CALIFORNIA NETWORK)

U.S. Vice President Joe Biden paid Pope Francis a little visit on Friday to talk cancer and Christian persecution. LOS ANGELES, CA (Catholic Online) -  Biden traveled to the Vatican to attend a summit on regenerative medicine. While at the Vatican, Biden pushed ... continue reading


Fountain of youth discovered: Immortality no longer a myth Watch

Image of Doctor explains theory to keep humans alive for centuries (Pinterest).

By Kenya Sinclair (CALIFORNIA NETWORK)

If given the option, would YOU choose to live forever? LOS ANGELES, CA (Catholic Online) - Dr. Aubrey de Grey, the co-founder and chief science officer for Strategies for Engineered Negligible Senescense (SENS) Research Foundation, believes the ongoing research ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Subscribe to Catholic OnlineYouTube Channel

the FEED
by Catholic Online

  • Nun fatally attacked in South Sudan
  • Benedict XVI to make public appearance?
  • Daily Reading for Thursday, May 26th, 2016 HD Video
  • Prayer to Holy Michael the Archangel HD Video
  • Goodbye El Nino! Hello La Nina! What does this mean for the Atlantic ...
  • St. Mary Magdalene de Pazzi: Saint of the Day for Wednesday, May 25, 2016
  • Daily Readings for Wednesday, May 25, 2016

Daily Readings

Reading 1, First Peter 1:10-16
10 This salvation was the subject of the search and investigation of the ... Read More

Psalm, Psalms 98:1, 2-3, 3-4
1 [Psalm] Sing a new song to Yahweh, for he has performed wonders, his ... Read More

Gospel, Mark 10:28-31
28 Peter took this up. 'Look,' he said to him, 'we have left everything ... Read More

Saint of the Day

Saint of the Day for May 24th, 2016 Image

St. David I of Scotland
May 24: David, the youngest son of Scotland's virtuous ... Read More