Study: Gene mutation may actually prevent heart disease
By Catholic Online (NEWS CONSORTIUM)
6/19/2014 (2 years ago)
Catholic Online (www.catholic.org)
Mutations to a particular gene can dramatically lower the risk for heart attack, scientists have found. Researchers are now trying to develop drugs that target the gene in order to bring down the high rate of heart disease in the U.S. population.
Many people still have elevated triglycerides despite exercising, eating a low fat, low carbohydrate diet and taking statin drugs. An agent that targets APOC3 may further reduce blood fats, lowering the risk of heart attack.
LOS ANGELES, CA (Catholic Online) - Recent studies have identified a gene called APOC3 in connection with the body's removal of triglycerides, a type of blood fat. Triglycerides, if they are not eliminated from the body, stick to blood vessels. They wind up stored in the hips and belly.
Elevated, triglycerides, or lipids, are thought to be a risk factor for heart disease. It's believed that approximately one in 150 people has mutations to the APOC3 gene that keep their triglyceride levels low.
A thorough investigation of 110,000 patient blood samples found those with the rare mutations had lower levels of triglyceride fats. These patients had a significantly reduced risk for the most common form of heart disease.
"We compared the heart attack rates of people who carried the mutations and those who didn't, and found that people who carried the mutations and had the lower triglycerides had 40 percent lower risk for heart attack," Sekar Kathiresan, director of Preventive Cardiology at Massachusetts General Hospital said. Kathiresan is an associate researcher at the Broad Institute of Biomedical Research and helped lead the study that identified four beneficial genetic mutations to the APOC3 protein.
Elevated LDL, which is a blood fat commonly called "bad cholesterol" and its connection to heart disease is well-known. Experts know less about the benefits of raising HDL, or a blood lipid called "good cholesterol," as a hedge against heart attack, and the role triglycerides levels play in coronary artery disease.
The latest study of thousands of research subjects found elevated levels of good cholesterol were not protective, while low triglyceride levels appear to be.
With the discovery of the four mutations, researchers say they now have a target to develop a drug to lower blood lipids, which in turn will lead to the reduced risk of heart attack and stroke.
"Given that these people are naturally protected, if you develop a medicine that mimics this, then your chances of it working in terms of reducing the risk of heart attack are quite great," Kathiresan said.
Many people still have elevated triglycerides despite exercising, eating a low fat, low carbohydrate diet and taking statin drugs. An agent that targets APOC3 may further reduce blood fats, lowering the risk of heart attack, he said.
These findings were shared in two papers published this week in the New England Journal of Medicine.
Copyright 2017 - Distributed by THE CALIFORNIA NETWORK
Pope Francis Prayer Intentions for MARCH 2017
Support for Persecuted Christians. That persecuted Christians may be supported by the prayers and material help of the whole Church.
If you are afraid of cancer, we have bad news. There may be little way to avoid the dreaded disease. A new study affirms that two-thirds of ... continue reading
Supreme Court nominee Neil Gorsuch made a crucial ethical distinction in his response to questions about doctor-prescribed suicide during ... continue reading
'Three-parent babies' are coming. We are resistant to wisdom, let's pray we are resistant to the consequences Watch
British doctors have been given the OK to create embryos from three parents to prevent genetic diseases. The first such child could be born ... continue reading
California could REBEL against Obama AND Trump and build its own single payer system, but who will pay for it? Watch
California is a large, wealthy state dominated by Democrats. Its economy, even if a bad year, is among the top ten in the world. The state ... continue reading
After ten years, a 60-person medical team, and a 56-hour surgery, 31-year-old Andy Sandness received the first steps into truly getting his ... continue reading
by Catholic Online
- Victims of a failing system or child abusers? Couple leaves young ...
- Newborn rescued from shallow grave as India murders its daughters
- St. Berthold: Saint of the Day for Wednesday, March 29, 2017
- Cause of California's drought is revealed HD Video
- Daily Readings for Wednesday, March 29, 2017
- 'Living Lent': Wednesday of the Fourth Week of Lent - Day 29
- Daily Reading for Thursday, March 30th, 2017 HD Video
- Pope Francis' important message for children HD
- Daily Reading for Wednesday, March 29th, 2017 HD
- Supermassive black hole discovered surfing gravitational wave HD
- Catholic Archdiocese of Mexico calls out 'traitor' Mexicans HD
Copyright 2017 Catholic Online. All materials contained on this site, whether written, audible or visual are the exclusive property of Catholic Online and are protected under U.S. and International copyright laws, © Copyright 2017 Catholic Online. Any unauthorized use, without prior written consent of Catholic Online is strictly forbidden and prohibited.