Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

6/19/2014 (2 months ago)

Catholic Online (www.catholic.org)

Lower levels of triglyceride fats significantly reduces risk for heart disease

Mutations to a particular gene can dramatically lower the risk for heart attack, scientists have found. Researchers are now trying to develop drugs that target the gene in order to bring down the high rate of heart disease in the U.S. population.

Many people still have elevated triglycerides despite exercising, eating a low fat, low carbohydrate diet and taking statin drugs. An agent that targets APOC3 may further reduce blood fats, lowering the risk of heart attack.

Many people still have elevated triglycerides despite exercising, eating a low fat, low carbohydrate diet and taking statin drugs. An agent that targets APOC3 may further reduce blood fats, lowering the risk of heart attack.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

6/19/2014 (2 months ago)

Published in Health

Keywords: Mutations, gene, heart disease, good cholesterol, bad cholesterol


LOS ANGELES, CA (Catholic Online) - Recent studies have identified a gene called APOC3 in connection with the body's removal of triglycerides, a type of blood fat. Triglycerides, if they are not eliminated from the body, stick to blood vessels. They wind up stored in the hips and belly.

Elevated, triglycerides, or lipids, are thought to be a risk factor for heart disease. It's believed that approximately one in 150 people has mutations to the APOC3 gene that keep their triglyceride levels low.

Light up the darkness -- by going here --

A thorough investigation of 110,000 patient blood samples found those with the rare mutations had lower levels of triglyceride fats. These patients had a significantly reduced risk for the most common form of heart disease.

"We compared the heart attack rates of people who carried the mutations and those who didn't, and found that people who carried the mutations and had the lower triglycerides had 40 percent lower risk for heart attack," Sekar Kathiresan, director of Preventive Cardiology at Massachusetts General Hospital said. Kathiresan is an associate researcher at the Broad Institute of Biomedical Research and helped lead the study that identified four beneficial genetic mutations to the APOC3 protein. 

Elevated LDL, which is a blood fat commonly called "bad cholesterol" and its connection to heart disease is well-known. Experts know less about the benefits of raising HDL, or a blood lipid called "good cholesterol," as a hedge against heart attack, and the role triglycerides levels play in coronary artery disease.

The latest study of thousands of research subjects found elevated levels of good cholesterol were not protective, while low triglyceride levels appear to be.

With the discovery of the four mutations, researchers say they now have a target to develop a drug to lower blood lipids, which in turn will lead to the reduced risk of heart attack and stroke.

"Given that these people are naturally protected, if you develop a medicine that mimics this, then your chances of it working in terms of reducing the risk of heart attack are quite great," Kathiresan said.

Many people still have elevated triglycerides despite exercising, eating a low fat, low carbohydrate diet and taking statin drugs. An agent that targets APOC3 may further reduce blood fats, lowering the risk of heart attack, he said.

These findings were shared in two papers published this week in the New England Journal of Medicine.

---


Pope Francis: end world hunger through 'Prayer and Action'


2014 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for August 2014
Refugees:
That refugees, forced by violence to abandon their homes, may find a generous welcome and the protection of their rights.
Oceania: That Christians in Oceania may joyfully announce the faith to all the people of that region.



Comments


More Health

Do you eat pomegranates? Well here's a few reasons why you should Watch

Image of Pomegranates contain the chemical punicalagin, a form of a chemical compound known as polyphenol, which may help to prevent the inflammation that destroys brain cells known as micrologia.

By Catholic Online (NEWS CONSORTIUM)

An ingredient in pomegranate may help stop the spread of Alzheimer's disease, scientists from the University of Huddersfield claim. LOS ANGELES, CA (Catholic Online) - The chemical punicalagin, a form of a chemical compound known as polyphenol, helps prevent the ... continue reading


NEW HOPE IN EBOLA CRISIS: U.S. doctor released from hospital - cured Watch

Image of

By Catholic Online (NEWS CONSORTIUM)

Contracting the deadly African virus while he worked to save their lives, Dr. Kent Brantly became one of the handful of people from the United States to contract Ebola. Receiving treatment back in the U.S., Brantly walked out of the hospital to the waiting arms ... continue reading


HEALTH DISASTER: Is nearly half of all Americans destined to contract diabetes? Watch

Image of The irony of the situation is that Americans are generally living longer, which is a factor in their increased lifetime chance of developing type 2 diabetes. Americans are also not dying in the same proportions that they were, because of better treatment.

By Catholic Online (NEWS CONSORTIUM)

Has the United States reached the tipping point with diabetes and obesity? A shocking new study claims that nearly HALF of all Americans, if trends continue, will develop type 2 diabetes in the near future. Public Health England, in their most recent report ... continue reading


First large-scale shipment of new malaria drug shipped out Watch

Image of The recent shipment marks a new phase in the fight against the mosquito-borne disease.

By Catholic Online (NEWS CONSORTIUM)

Just as virulent - as far more easily transmitted than Ebola, malaria is making new inroads to populations in sub-Saharan Africa. In response, French drug maker Sanofi has announced the delivery of large-scale batches of an antimalarial drug made using ... continue reading


Very accurate colon cancer in-home detection kit approved by FDA Watch

Image of  The U.S. Food and Drug Administration has approved a new at-home, DNA-based stool test that screens for colorectal cancer with more than 90 percent accuracy.

By Catholic Online (NEWS CONSORTIUM)

Screening for colon cancer is frequently arduous and invasive. Patients need to fast prior to a colonoscopy, and the colonoscopy itself be highly uncomfortable and not always accurate. There's now good news for those at risk. The U.S. Food and Drug ... continue reading


You'll think twice before you put this dangerous chemical back in your mouth! Watch

Image of Colgate's Total brand of toothpaste contains the chemical triclosan, which has been proven to cause disruptions in the endocrine system in mice and rats.

By Catholic Online (NEWS CONSORTIUM)

A top-selling toothpaste uses the chemical triclosan which has been linked to cancer-cell growth and disrupted development in animals, and regulators are still reviewing whether or not it's safe to pt in soap, cutting boars and toys, while many consumer companies ... continue reading


New diabetes drug could help us all: Found effective in preventing cancer Watch

Image of Scientists who studied more than 180,000 people found a

By Catholic Online (NEWS CONSORTIUM)

According to a new study, a drug widely prescribed to treat type 2 diabetes could help us all live longer. Said drug, metformin, which controls glucose levels, may also stave off cardiovascular disease and cancer, regardless if the person is diabetic. LOS ... continue reading


Mutated gene increases women's chance for breast cancer by threefold Watch

Image of Doctors also could recommend more aggressive surveillance for breast cancer, such as annual mammograms or MRI breast screening.

By Catholic Online (NEWS CONSORTIUM)

A new study has found that mutated versions of a gene called PALB2 can dramatically increase a woman's risk of breast cancer. Researchers say that women carrying the PALB2 mutation have a one in three chance of developing breast cancer by the age of 70. LOS ... continue reading


WAS WORLD'S THROAT CUT? Ebola vaccine research was earlier abandoned Watch

Image of It must also be noted that while the National Institutes of Health and the U.S. government often fund the early animal safety and efficacy testing of a vaccine, pharmaceutical companies typically fund the human clinical trials to take a drug or vaccine to market.

By Catholic Online (NEWS CONSORTIUM)

With increasing fears of the Ebola virus in West Africa and elsewhere, world governments are now frantically trying to contain the disease. What is not widely known is the fact that there had been work on finding a vaccine for Ebola four years ago, that was ... continue reading


PLAGUE STRIKES HOME: At least six people tested for Ebola in U.S. Watch

Image of Said individual, who has recently traveled to West Africa where the current outbreak is taking place is said to be under

By Catholic Online (NEWS CONSORTIUM)

At least six people within the continental United States have been tested for the dreaded Ebola virus, the deadly hemorrhagic disease tearing through West Africa. While all six people tested negative, the states in which these people were from remains a tightly ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, First Corinthians 2:1-5
1 Now when I came to you, brothers, I did not come ... Read More

Psalm, Psalms 119:97, 98, 99, 100, 101, 102
97 How I love your Law! I ponder it all day ... Read More

Gospel, Luke 4:16-30
16 He came to Nazara, where he had been brought up, ... Read More

Saint of the Day

Saint of the Day for September 1st, 2014 Image

St. Giles, Abbot
September 1: St. Giles, Abbot (Patron of Physically Disabled) Feast day - ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter