Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

4/6/2014 (6 months ago)

Catholic Online (www.catholic.org)

Drug cut in half the risk that cancer would worsen

An important treatment option in the fight against breast cancer may be waiting in the wings. Researchers say a new type of drug could help prevent advanced breast cancer from worsening. The potential is great for breast cancer patients, and makes for a potential blockbuster product for Pfizer.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

4/6/2014 (6 months ago)

Published in Health

Keywords: Pfizer, breast cancer, palbociclib


LOS ANGELES, CA (Catholic Online) - Said drug cut in half the risk that cancer would worsen, or progress, researchers said. The median time before the disease progressed or the women died was 20.2 months for those who received the drug, compared with 10.2 months for the control group.

"The magnitude of benefit we are seeing is not something commonly seen in cancer medicine studies," Dr. Richard S. Finn, a principal investigator in the study, says. Finn, an oncologist at the University of California, Los Angeles, called the results "quite groundbreaking."

No child need ever go to bed hungry -- Learn how you can help!


Known as palbociclib, the drug also appeared to prolong survival but not by a statistically significant amount. Those who received the drug lived a median of 37.5 months in contrast with 33.3 months for those in the control group.

The results from the Phase 2, or mid-stage, study were presented here at the annual meeting of the American Association for Cancer Research. Palbociclib is considered a jewel in Pfizer's product pipeline, with analysts predicting annual sales of billions of dollars. Amgen is entitled to an eight percent royalty on sales of the drug.

Some investors may have been letdown due to the drug, partly because they were not quite as good as interim results presented about halfway through the trial. At that point, the difference in median progression-free survival was 26.1 months for palbociclib versus 7.5 months for the control group.

Finn stresses that a statistically significant survival benefit should not have been expected at this point because only 61 of the 165 patients in the trial had died. Patients can use other drugs after leaving the trial, which can dilute any effect of palbociclib.

Palbociclib slows the proliferation of cancer cells by inhibiting the activity of two related enzymes involved in cell division; cyclin-dependent kinases 4 and 6.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor. While breast cancer is the initial focus, the drugs are being tested for other cancers.

Breast cancer specialists not involved in the study were encouraged -- but expressed caution. "These results are strikingly positive and with a large potential impact to patients," Dr. Josť Baselga said in a speech at the conference discussing the results.

Baselga, the physician in chief at the Memorial Sloan-Kettering Cancer Center, also said the results might have been biased because the study investigators, who determined whether tumors had progressed, knew which patients were getting palbociclib.

Dr. Eric P. Winer, chief of women's cancers at the Dana-Farber Cancer Institute in Boston, says larger studies were still needed.

"This is a small Phase 2 trial - not tiny, but not the kind of study that would typically lead to a change in practice," he said.

---


Pope Francis: end world hunger through 'Prayer and Action'


© 2014 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for October 2014
Peace:
That the Lord may grant peace to those parts of the world most battered by war and violence.
World Mission Day: That World Mission Day may rekindle in every believer zeal for carrying the Gospel into all the world.



Comments


More Health

NOT long enough: Ebola could lay dormant in the body for longer than 21 days, expert claims Watch

Image of Biology Professor Charles Hass, who has vast experience of analyzing the risk of transmitting biological pathogens, said

By Catholic Online (NEWS CONSORTIUM)

A new study warns that the recommended 21-day quarantine period for the Ebola virus is not long enough to contain the spread of the disease. While the World Health Organization advises the incubation period for the virus is between two and 21 days, scientists ... continue reading


Nurse says Texas Presbyterian Hospital was chaotic and filthy during Ebola outbreak Watch

Image of

By Catholic Online (NEWS CONSORTIUM)

Texas Presbyterian Hospital in Dallas, Texas, reacted very poorly when it discovered that they had been treating a Liberian man with Ebola. According to a nurse who has since come forward, safety regulations were blithely ignored, contaminated linens and waste ... continue reading


Why aren't we doing this? Colombia bans entry to those from Ebola affected countries Watch

Image of A Liberian man is having his temperature taken by a no-contact thermometer.

By Catholic Online (NEWS CONSORTIUM)

Two countries have started barring entry to people coming from the nations in West Africa that have been hardest hit by the current Ebola outbreak. LOS ANGELES, CA (Catholic Online) - Kenny Anthony, the prime minister of St. Lucia-a small island nation in the ... continue reading


Second Dallas health worker contracts Ebola virus Watch

Image of Workers scrub down Amber Vinson's apartment in Dallas, Texas.

By Catholic Online (NEWS CONSORTIUM)

A second Dallas health care worker has since contracted the Ebola virus - and authorities are now frantically trying to contact the more than 100 plus passengers with whom she shared a flight. Authorities says that the employee, Amber Vinson reportedly showed ... continue reading


World has until Christmas to control Ebola; all bets off afterwards Watch

Image of The World Health Organization, or WHO earlier said there could be 10,000 new cases of Ebola per week within two months.

By Catholic Online (NEWS CONSORTIUM)

The United Nations says the Ebola outbreak must be controlled within 60 days. Otherwise, the world faces an "unprecedented" situation for which there is no plan. Ebola, according to the U.N. "is running faster than us and it is winning the race." LOS ANGELES, ... continue reading


The horrifying truth of Ebola: WHO suggests 10,000 could become infected per week Watch

Image of An aid worker carries a child infected with Ebola in Liberia, one of the West African nations hardest hit by the outbreak.

By Catholic Online (NEWS CONSORTIUM)

The World Health Organization (WHO) has issued a dire warning to the world. On October 14 they announced that the death rate of the current Ebola outbreak in West Africa is now 70%, much higher than usual. Even more horrifying, the WHO has stated that West Africa ... continue reading


Ebola is 'the most severe, acute health emergency seen in modern times' -- WHO Watch

Image of Ninety percent of economic costs of any outbreak

By Catholic Online (NEWS CONSORTIUM)

Deaths from the currently Ebola epidemic has sailed past the 4,000 mark this week, with the majority of deaths confined to West Africa: Liberia, Sierra Leone and Guinea are the nations most impacted by the disease. But as the first death in the United States from Ebola ... continue reading


Stem cell breakthrough could save diabetics from daily injections Watch

Image of Patients could receive a single transplant with the newly generated cells, which would then read out the amount of sugar in the blood and squirt out just the right amount of the hormone insulin.

By Catholic Online (NEWS CONSORTIUM)

Scientists have announced a stem cell breakthrough that could one day free millions of diabetics from a lifetime of insulin injections. Stem cell researcher Douglas Melton has conceived of a method of growing billions of precious insulin-secreting cells en ... continue reading


Safety protocols called into question after first case of Ebola contracted on U.S. soil Watch

Image of More than 4,000 people have died of Ebola since the start of the year usually in Guinea, Sierra Leone and Liberia. The epidemic appears to be outpacing efforts to fight it.

By Catholic Online (NEWS CONSORTIUM)

While Thomas Duncan from Liberia may have been America's "patient zero" in regards to Ebola, the nurse who treated him that has since fallen ill from the disease represents the first instance of Ebola being contracted on U.S. soil. Health officials, who believe ... continue reading


Texas nurse becomes second U.S. citizen to become infected with Ebola Watch

Image of The CDC has now issued a recommendation that the number of healthcare workers who treat any Ebola patients be kept to an absolute minimum to reduce the chances of exposure.

By Catholic Online (NEWS CONSORTIUM)

The news is not good. A female nurse who treated America's "patient zero" with the Ebola virus - who later died - has been placed in isolation after testing positive for the disease. She remains at Texas Health Presbyterian Hospital under lockdown. The U.S. ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Ephesians 2:1-10
1 And you were dead, through the crimes and the ... Read More

Psalm, Psalms 100:2, 3, 4, 5
2 serve Yahweh with gladness, come into his presence ... Read More

Gospel, Luke 12:13-21
13 A man in the crowd said to him, 'Master, tell my ... Read More

Saint of the Day

Saint of the Day for October 20th, 2014 Image

St. Paul of the Cross
October 20: St. Paul of the Cross was born at Ovada in the Republic of ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter