Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

4/6/2014 (1 year ago)

Catholic Online (www.catholic.org)

Drug cut in half the risk that cancer would worsen

An important treatment option in the fight against breast cancer may be waiting in the wings. Researchers say a new type of drug could help prevent advanced breast cancer from worsening. The potential is great for breast cancer patients, and makes for a potential blockbuster product for Pfizer.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

4/6/2014 (1 year ago)

Published in Health

Keywords: Pfizer, breast cancer, palbociclib


LOS ANGELES, CA (Catholic Online) - Said drug cut in half the risk that cancer would worsen, or progress, researchers said. The median time before the disease progressed or the women died was 20.2 months for those who received the drug, compared with 10.2 months for the control group.

"The magnitude of benefit we are seeing is not something commonly seen in cancer medicine studies," Dr. Richard S. Finn, a principal investigator in the study, says. Finn, an oncologist at the University of California, Los Angeles, called the results "quite groundbreaking."

No child need ever go to bed hungry -- Learn how you can help!


Known as palbociclib, the drug also appeared to prolong survival but not by a statistically significant amount. Those who received the drug lived a median of 37.5 months in contrast with 33.3 months for those in the control group.

The results from the Phase 2, or mid-stage, study were presented here at the annual meeting of the American Association for Cancer Research. Palbociclib is considered a jewel in Pfizer's product pipeline, with analysts predicting annual sales of billions of dollars. Amgen is entitled to an eight percent royalty on sales of the drug.

Some investors may have been letdown due to the drug, partly because they were not quite as good as interim results presented about halfway through the trial. At that point, the difference in median progression-free survival was 26.1 months for palbociclib versus 7.5 months for the control group.

Finn stresses that a statistically significant survival benefit should not have been expected at this point because only 61 of the 165 patients in the trial had died. Patients can use other drugs after leaving the trial, which can dilute any effect of palbociclib.

Palbociclib slows the proliferation of cancer cells by inhibiting the activity of two related enzymes involved in cell division; cyclin-dependent kinases 4 and 6.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor. While breast cancer is the initial focus, the drugs are being tested for other cancers.

Breast cancer specialists not involved in the study were encouraged -- but expressed caution. "These results are strikingly positive and with a large potential impact to patients," Dr. José Baselga said in a speech at the conference discussing the results.

Baselga, the physician in chief at the Memorial Sloan-Kettering Cancer Center, also said the results might have been biased because the study investigators, who determined whether tumors had progressed, knew which patients were getting palbociclib.

Dr. Eric P. Winer, chief of women's cancers at the Dana-Farber Cancer Institute in Boston, says larger studies were still needed.

"This is a small Phase 2 trial - not tiny, but not the kind of study that would typically lead to a change in practice," he said.

---


Pope Francis: end world hunger through 'Prayer and Action'


Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for July 2015
Universal:
That political responsibility may be lived at all levels as a high form of charity.
Evangelization: That, amid social inequalities, Latin American Christians may bear witness to love for the poor and contribute to a more fraternal society.



Comments


More Health

Heart pump, size of a golf ball, could change lives of millions of patients Watch

Image of

By Catholic Online (NEWS CONSORTIUM)

Retired father-of-three, 63-year-old Harry Chivers suffered a heart attack last year. His health failing, he anxiously awaited for a possible heart transplant when he was offered the chance to become a pioneer in heart health research. Fitted with a heart pump ... continue reading


Do you know what a can of Coke really does to your body? Watch

Image of

By Atarah Haely (NEWS CONSORTIUM)

Although Coke and sodas are a favorite for people all over the world, sodas are something that slowly changes our health and can lead into a number of diseases from the high amount of processed sugar. Starting from the first 10 minutes after a can of Coke is consumed, ... continue reading


Discovery of five different kinds of prostate cancer heralded as breakthrough Watch

Image of While many men have prostate cancer, it can grow so slowly it might not cause any problems until the patient eventually dies of something else.

By Catholic Online (NEWS CONSORTIUM)

Scientists in the United Kingdom have discovered the most common cancer among men can be classified into five types, depending on its DNA. This is a breakthrough in prostate cancer research, and once the type of cancer is identified, the patient's survival rate ... continue reading


8-year-old boy becomes youngest double-hand transplant patient Watch

Image of

By Talia Ramos (NEWS CONSORTIUM)

Surgeons believe 8-year-old Zion Harvey is the youngest to receive a double-hand transplant. The boy lost both of his hands over a severe infection years ago and opted to go through a transplant with the support of his parents. After the initial success of the ... continue reading


World's first malaria vaccine wins approval from European drug regulators Watch

Image of Mosquirix must first win agreement from African governments as the vaccine only offers only partial protection.

By Catholic Online (NEWS CONSORTIUM)

The world's first malaria vaccine is a go with European drug regulators after it was recommended safe and effective for babies at risk of the 'mosquito-born disease' in Africa. LOS ANGELES, CA (Catholic Online) - Called Mosquirix, the vaccine was developed by ... continue reading


560-pound man sets out to bike across the U.S. to lose weight and save his marriage Watch

Image of [Photo by: ABC News]

By Talia Ramos (NEWS CONSORTIUM)

To try to live a healthy life, get a job and save his failing marriage, a 560-pound man decided to embark on a biking journey across the United States. He has already traveled about 90 miles since he started last month and has lost around 60 pounds during the first two ... continue reading


Catholic organization's approach to female reproductive health a 'game changer' Watch

Image of Together with his colleagues, Dr. Thomas Hilgers developed NaPro (Natural Procreative) Technology. In Omaha in 1985, they founded the Pope Paul VI Institute for the Study of Human Reproduction, and in 1999 formally created the Creighton Model FertilityCare System.

By Gabrielle Cubera, CNA EWTN News

With the hope of providing authentic and ethical health care for women, Dr. Thomas Hilgers, creator of Natural Procreative Technology, has worked for decades to establish a medical network that studies, understands, and treats the female fertility cycle. Omaha, ... continue reading


Have scientists found the key to shut off aging? New study with worms finds success Watch

Image of

By Nikky Andres (NEWS CONSORTIUM)

Scientists have uncovered how to switch off the aging process, during a recent study with worms, which could possibly lead to the process being successful in humans. MUNTINLUPA, PHILIPPINES (Catholic Online) - The new study showed that adult cells of worms shortly ... continue reading


New eye drops may soon replace cataract surgery Watch

Image of Vision could cease altogether if cataracts remain untreated. Cataracts cause more blindness worldwide than any other eye condition.

By Catholic Online (NEWS CONSORTIUM)

Inexpensive and easy to administer, a new eye drop may soon make cataract removal surgery obsolete. A frequent bane of existence that afflicts the elderly, the new drops dissolves the clumps of protein that clouds vision. LOS ANGELES, CA (Catholic Online) - Cataract ... continue reading


Superhero DNA desired by pharmaceutical researchers for new drugs Watch

Image of

By Atarah Haely (NEWS CONSORTIUM)

They don't have the ability to fly or come with laser eyes, but there are people who exist today with the "superhero" genes. Similar to the figures portrayed in media, these people have ordinary lives with extraordinary physical abilities because of uncommon biological ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Exodus 16:2-4, 12-15
2 And the whole community of Israelites began ... Read More

Psalm, Psalms 78:3-4, 23-24, 25, 54
3 What we have heard and know, what our ancestors ... Read More

Gospel, John 6:24-35
24 When the people saw that neither Jesus nor his ... Read More

Reading 2, Ephesians 4:17, 20-24
17 So this I say to you and attest to you in the ... Read More

Saint of the Day

Saint of the Day for August 2nd, 2015 Image

St. Eusebius of Vercelli
August 2: Christians who breathed a sigh of relief when Constantine ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter