Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

4/6/2014 (11 months ago)

Catholic Online (www.catholic.org)

Drug cut in half the risk that cancer would worsen

An important treatment option in the fight against breast cancer may be waiting in the wings. Researchers say a new type of drug could help prevent advanced breast cancer from worsening. The potential is great for breast cancer patients, and makes for a potential blockbuster product for Pfizer.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

4/6/2014 (11 months ago)

Published in Health

Keywords: Pfizer, breast cancer, palbociclib


LOS ANGELES, CA (Catholic Online) - Said drug cut in half the risk that cancer would worsen, or progress, researchers said. The median time before the disease progressed or the women died was 20.2 months for those who received the drug, compared with 10.2 months for the control group.

"The magnitude of benefit we are seeing is not something commonly seen in cancer medicine studies," Dr. Richard S. Finn, a principal investigator in the study, says. Finn, an oncologist at the University of California, Los Angeles, called the results "quite groundbreaking."

No child need ever go to bed hungry -- Learn how you can help!


Known as palbociclib, the drug also appeared to prolong survival but not by a statistically significant amount. Those who received the drug lived a median of 37.5 months in contrast with 33.3 months for those in the control group.

The results from the Phase 2, or mid-stage, study were presented here at the annual meeting of the American Association for Cancer Research. Palbociclib is considered a jewel in Pfizer's product pipeline, with analysts predicting annual sales of billions of dollars. Amgen is entitled to an eight percent royalty on sales of the drug.

Some investors may have been letdown due to the drug, partly because they were not quite as good as interim results presented about halfway through the trial. At that point, the difference in median progression-free survival was 26.1 months for palbociclib versus 7.5 months for the control group.

Finn stresses that a statistically significant survival benefit should not have been expected at this point because only 61 of the 165 patients in the trial had died. Patients can use other drugs after leaving the trial, which can dilute any effect of palbociclib.

Palbociclib slows the proliferation of cancer cells by inhibiting the activity of two related enzymes involved in cell division; cyclin-dependent kinases 4 and 6.

While Pfizer remains in the lead to bring this new class of drugs to market, Novartis has begun late-stage testing of its own CDK 4/6 inhibitor. While breast cancer is the initial focus, the drugs are being tested for other cancers.

Breast cancer specialists not involved in the study were encouraged -- but expressed caution. "These results are strikingly positive and with a large potential impact to patients," Dr. Josť Baselga said in a speech at the conference discussing the results.

Baselga, the physician in chief at the Memorial Sloan-Kettering Cancer Center, also said the results might have been biased because the study investigators, who determined whether tumors had progressed, knew which patients were getting palbociclib.

Dr. Eric P. Winer, chief of women's cancers at the Dana-Farber Cancer Institute in Boston, says larger studies were still needed.

"This is a small Phase 2 trial - not tiny, but not the kind of study that would typically lead to a change in practice," he said.

---


Pope Francis: end world hunger through 'Prayer and Action'


Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for March 2015
Universal:
Scientists: That those involved in scientific research may serve the well-being of the whole human person.
Evangelization: Contribution of women: That the unique contribution of women to the life of the Church may be recognized always.


Rosaries, Crosses, Prayer Cards and more... by Catholic Shopping .com


Comments


More Health

5 Super Simple Ways to help Age Proof your Eyes and Vision Watch

Image of Protect your eyes as they are very precious.

By Wendy RN., BA, MBA

Everyone wants to have good eyesight well into their later years. Here are 5 super easy ways to help protect your eyes and your vision. LOS ANGELES, CA - (Rise Above Health) Your eyes are an important part of your health. To make sure your eyes are healthy and you ... continue reading


Drink your coffee with confidence - daily java proven to prevent liver cancer Watch

Image of Coffee seems to protect people from liver cancer, which killed 746,000 people around the world in 2012.

By Catholic Online (NEWS CONSORTIUM)

There are many reasons to watch you alcoholic beverage intake. Researchers say more than three alcoholic drinks a day increases your risk for this highly deadly version of the disease. The good news: It appears that the consumption of coffee, rich in ... continue reading


New biomarker detects body reaction to chemotherapy improving cancer treatment Watch

Image of

By Hannah Raissa Marfil (NEWS CONSORTIUM)

A reason many patients lose their chance of surviving ovarian cancer is because they are opting out of chemotherapy. With a recent discovery, researchers are hoping this new biomarker will help patients with high-grade serious ovarian cancer (HGSC) and thus, make ... continue reading


Are you washing your hair wrong? How to get hair salon results at home Watch

Image of

By Hannah Raissa Marfil (NEWS CONSORTIUM)

Do you feel like you have bad hair almost everyday, but after you go to a salon, it feels like it has transformed into something completely different: silky and soft. Hairdressers have no magic tricks, but they have tips they've learned from training. You may actually ... continue reading


World's oldest evidence of breast cancer found in 4,200-year-old Egyptian skeleton Watch

Image of

By Catholic Online (NEWS CONSORTIUM)

While one of the leading causes of death, cancer is virtually absent in archaeological records of ancient man. The notion that modern lifestyles, people living longer and man-made chemicals being responsible for the disease has been accepted as a given by many. ... continue reading


5 Most Important Foods for Beautiful Healthy Hair Watch

Image of When it comes to healthy hair, it's not just what you put on your hair that counts it is your diet that matters most!

By Wendy RN., BA, MBA

Who doesn't want a gorgeous, glossy mane of beautiful, bouncy, shiny healthy hair. The secret is more about what we eat, than all the expensive products that we put on our hair.  LOS ANGELES, CA - (Rise Above Health), Regardless of the type of hair you have, the ... continue reading


Doctors say daily dose of cereal is good for you! Here's why Watch

Image of The findings, published in the journal BMC Medicine, suggest that the cereal fiber component of whole grains accounts for the actions of the whole grains, and that cereal fiber-rich whole grain foods may have health benefits.

By Catholic Online (NEWS CONSORTIUM)

Most people start their day with a bowl of cereal, porridge or oatmeal - and it is actually good for you! Doctors say that a diet high in grain cuts the risk for both cancer and diabetes. LOS ANGELES, CA (Catholic Online) - Starting the day this way can add years ... continue reading


Once-a-day tablet said to 'turn off cancer' Watch

Image of One of only a handful of new medicines to be made available via the Cancer Drugs Fund, two trials in 28 British hospitals found Ibrutinib to be extremely effective in treating both mantle cell lymphoma, or MCL and chronic lymphocytic leukemia, or CLL.

By Catholic Online (NEWS CONSORTIUM)

Ibrutinib, hailed as a revolutionary drug capable of "switching off" cancer may soon be offered to patients with some forms of the disease. The once-a-day tablet could spare blood cancer patients the sometimes-agonizing side effects of chemotherapy. LOS ... continue reading


Is your child on the wrong path? Childhood inactivity could lead to becoming 'middle-aged couch potatoes' Watch

Image of

By Hannah Raissa Marfil (NEWS CONSORTIUM)

Inactive children are more likely to grow up and become middle-aged couch potatoes, as reported by BBC News. The findings, in a study from University College London, were children at age 10, who spent most of their time watching television shows are 42 percent more ... continue reading


Drinking diet soda may actually increase belly fat: New study dissects the link between artificial sweeteners and your waistline Watch

Image of

By Hannah Raissa Marfil (NEWS CONSORTIUM)

New studies show consumption of diet soda leads to belly fat. The presence of belly fat may be what medical studies has been missing in the analysis between artificial sweeteners and serious health risks, although some other factors can contribute. MUNTINLUPA, ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Isaiah 42:1-7
1 Here is my servant whom I uphold, my chosen one in ... Read More

Psalm, Psalms 27:1, 2, 3, 13-14
1 [Of David] Yahweh is my light and my salvation, ... Read More

Gospel, John 12:1-11
1 Six days before the Passover, Jesus went to ... Read More

Saint of the Day

Saint of the Day for March 30th, 2015 Image

St. Peter Regulatus
March 30: Also Peter Regalado, Franciscan reformer. Peter was born at ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter