Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

2/22/2013 (1 year ago)

Catholic Online (www.catholic.org)

Kadcyla can cause heart, liver damage and birth defects

Kadcyla or ado-trastuzumab emtansine is a new drug for late-stage breast cancer patients that have dangerous side effects. Produced by Swiss drug-maker Roche, Kadcyla is for patients with late-stage metastatic breast cancer who fail to respond to other therapies.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

2/22/2013 (1 year ago)

Published in Health

Keywords: Kadcyla, breat cancer, Food and Drug Administration, Roche


LOS ANGELES, CA (Catholic Online) - The U.S. Food and Drug Administration approved Kadcyla this week, noting it was for patients whose cancer cells contain increased amounts of a protein known as HER2.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Patients who took the drug in clinical trials survived an average of 30.9 months, compared with 25.1 months in a control group.

It's estimated that Kadcyla could generate annual peak sales of $1.9 billion as usage in different settings increases. The drug will be priced at $9,800 a month.

"We don't expect to see significant payer push back on pricing at launch, given the drug's efficacy and safety," Simos Simeonidis, an analyst at Cowen and Company wrote in a research note.

Kadcyla works by attaching trastuzumab, sold under the brand name Herceptin, to a drug called DM1, developed by ImmunoGen Inc, which interferes with cancer cell growth.

"Kadcyla delivers the drug to the cancer site to shrink the tumor, slow disease progression and prolong survival," Dr. Richard Pazdur, director of the FDA's office of hematology and oncology products says. "It is the fourth approved drug that targets the HER2 protein."

Other drugs approved for the disease include Herceptin in 1998, lapatinib, made by GlaxoSmithKline Plc and sold under the brand name Tykerb in 2007, and pertuzumab, marketed as Perjeta and also made by Roche in 2012.

Kadcyla is the first drug in its class, known as antibody-drug conjugates, or "armed antibodies" to be approved to treat a solid tumor. These drugs combine an antibody, Herceptin in the case of Kadcyla, with a killer toxin, in this case ImmunoGen's DM1, and links them together to deliver a highly potent bomb to the diseased cells.

The drugs seek out specific cells that express proteins associated with the cancer, while leaving other cells unharmed.

Breast cancer is the second-leading cause of cancer-related death among women.

---


Pope Francis: end world hunger through 'Prayer and Action'


© 2014 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for September 2014
Mentally disabled:
That the mentally disabled may receive the love and help they need for a dignified life.
Service to the poor: That Christians, inspired by the Word of God, may serve the poor and suffering.



Comments


More Health

DARPA developing new implants for 'healing superpowers'' - Mark of the Beast? Probably, but it doesn't matter because you're already marked Watch

Image of Most people already carry the Mark of the Beast in some form.

By Catholic Online (NEWS CONSORTIUM)

The U.S. government, working through the Defense Advanced Research Projects Agency (DARPA), says it plans to develop tiny implants that will help soldiers and possibly ordinary citizens heal after injuries. The implants would be small enough to place at the ends of ... continue reading


This disease may foretell diabetes, heart attacks, or cancer and you may just have it! Watch

Image of Those with pre-diabetes can lower their chance of contracting diabetes with a healthy diet, exercise and weight loss.

By Catholic Online (NEWS CONSORTIUM)

Federal health statistics show that nearly half of all adults in the U.S. have either pre-diabetes or diabetes, severely raising their risk for heart attacks, blindness, amputations and cancer. LOS ANGELES, CA (Catholic Online) - These statistics show that 12.3% of ... continue reading


Are officials keeping facts about Ebola from the easily frightened public? Watch

Image of Some think the United Nations needs to address the Ebola crisis head on.

By Catholic Online (NEWS CONSORTIUM)

The current Ebola outbreak has the world terrified. While still largely confined to West Africa, there is very little the world can do to prevent an infected person from jumping on a plane and bringing it to another country. Are health officials deliberately ... continue reading


Anti-anxiety, sleeping pills now linked to onset of Alzheimer's disease Watch

Image of A special class of drugs used to reduce anxiety and induce sleep is now being blamed for increasing the risk of Alzheimer's twofold, according to a dismaying new report.

By Catholic Online (NEWS CONSORTIUM)

It now appears that the elderly have been taking a class of drugs to beat one condition, only to increase their risk for the dreaded memory-robbing diseases of Alzheimer's and dementia. A special class of drugs used to reduce anxiety and induce sleep is now ... continue reading


Amazing! Your computer might be able to tell if you have a heart condition Watch

Image of A pilot study has shown that a computer camera may be capable of telling when a person is having a heart condition, by picking up changes in skin tone.

By Catholic Online (NEWS CONSORTIUM)

Researchers may be able to accurately detect atrial fibrillation with just a regular laptop camera and some sophisticated software, a new pilot study reveals. LOS ANGELES, CA (Catholic Online) - The study reveals that this new system may be as accurate as a ... continue reading


Rare, unidentified illness striking nation's children Watch

Image of The rare new respiratory illness stalking the nation's children begins like an ordinary cold -- and then become much more serious.

By Catholic Online - (NEWS CONSORTIUM)

It's of high concern to the nation's parents: Thousands of kids in at least 10 U.S. have fallen ill to a mysterious respiratory illness. Doctors warn that this is likely to become a widespread, nationwide problem as the weather begins to cool. LOS ANGELES, CA ... continue reading


Every two minutes, an Indian commits suicide, new WHO study reveals Watch

Image of A new study from the World Health Organization has revealed that a third of all suicides in the world take place in India.

By Catholic Online (NEWS CONSORTIUM)

Every 40 seconds a person commits suicides, and a decade long study conduced by the World Health Organization (WHO) has revealed that every third suicide in the world takes place in India. LOS ANGELES, CA (Catholic Online) - The WHO believes that in 2012 alone, ... continue reading


New study shows that people with diabetes are more likely to suffer from tuberculosis Watch

Image of The rise of tuberculosis cases is especially hard hitting in Africa, where diabetes is also increasing.

By Catholic Online (NEWS CONSORTIUM)

The increasing number of Type 2 diabetes cases worldwide is going to make it more difficult to control and eliminate tuberculosis, experts have said after finding a connection between the two diseases. LOS ANGELES, CA (Catholic Online) - The reasons are still ... continue reading


Electric shocks to the brain can aid those who suffer from stroke, Alzheimer's, memory loss Watch

Image of Previously, TMS has been used in a limited way to temporarily change brain function to improve performance during a test. The new study shows that TMS can be used to improve memory for events at least 24 hours after the stimulation is given.

By Catholic Online (NEWS CONSORTIUM)

Applying electric shocks to the brain can improve memory, researchers have found. Furthermore, researchers say the discovery could develop exciting new approaches for treating strokes, early-stage Alzheimer's and aging on the brain. LOS ANGELES, CA (Catholic ... continue reading


Do you eat pomegranates? Well here's a few reasons why you should Watch

Image of Pomegranates contain the chemical punicalagin, a form of a chemical compound known as polyphenol, which may help to prevent the inflammation that destroys brain cells known as micrologia.

By Catholic Online (NEWS CONSORTIUM)

An ingredient in pomegranate may help stop the spread of Alzheimer's disease, scientists from the University of Huddersfield claim. LOS ANGELES, CA (Catholic Online) - The chemical punicalagin, a form of a chemical compound known as polyphenol, helps prevent the ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, First Corinthians 15:12-20
12 Now if Christ is proclaimed as raised from the ... Read More

Psalm, Psalms 17:1, 6-7, 8, 15
1 [Prayer Of David] Listen, Yahweh, to an upright ... Read More

Gospel, Luke 8:1-3
1 Now it happened that after this he made his way ... Read More

Saint of the Day

Saint of the Day for September 19th, 2014 Image

St. Januarius
September 19: St. Januarius was born in Italy and was bishop of Benevento ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter