Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

2/22/2013 (1 year ago)

Catholic Online (www.catholic.org)

Kadcyla can cause heart, liver damage and birth defects

Kadcyla or ado-trastuzumab emtansine is a new drug for late-stage breast cancer patients that have dangerous side effects. Produced by Swiss drug-maker Roche, Kadcyla is for patients with late-stage metastatic breast cancer who fail to respond to other therapies.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

2/22/2013 (1 year ago)

Published in Health

Keywords: Kadcyla, breat cancer, Food and Drug Administration, Roche


LOS ANGELES, CA (Catholic Online) - The U.S. Food and Drug Administration approved Kadcyla this week, noting it was for patients whose cancer cells contain increased amounts of a protein known as HER2.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Patients who took the drug in clinical trials survived an average of 30.9 months, compared with 25.1 months in a control group.

It's estimated that Kadcyla could generate annual peak sales of $1.9 billion as usage in different settings increases. The drug will be priced at $9,800 a month.

"We don't expect to see significant payer push back on pricing at launch, given the drug's efficacy and safety," Simos Simeonidis, an analyst at Cowen and Company wrote in a research note.

Kadcyla works by attaching trastuzumab, sold under the brand name Herceptin, to a drug called DM1, developed by ImmunoGen Inc, which interferes with cancer cell growth.

"Kadcyla delivers the drug to the cancer site to shrink the tumor, slow disease progression and prolong survival," Dr. Richard Pazdur, director of the FDA's office of hematology and oncology products says. "It is the fourth approved drug that targets the HER2 protein."

Other drugs approved for the disease include Herceptin in 1998, lapatinib, made by GlaxoSmithKline Plc and sold under the brand name Tykerb in 2007, and pertuzumab, marketed as Perjeta and also made by Roche in 2012.

Kadcyla is the first drug in its class, known as antibody-drug conjugates, or "armed antibodies" to be approved to treat a solid tumor. These drugs combine an antibody, Herceptin in the case of Kadcyla, with a killer toxin, in this case ImmunoGen's DM1, and links them together to deliver a highly potent bomb to the diseased cells.

The drugs seek out specific cells that express proteins associated with the cancer, while leaving other cells unharmed.

Breast cancer is the second-leading cause of cancer-related death among women.

---


Pope Francis: end world hunger through 'Prayer and Action'


© 2014 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for December 2014
Christmas, hope for humanity:
That the birth of the Redeemer may bring peace and hope to all people of good will.
Parents: That parents may be true evangelizers, passing on to their children the precious gift of faith.



Comments


More Health

New plague panic? New strains of malaria appear immune to current treatment Watch

Image of Mass drug treatments have been tried before with varying success.

By Astrid Zweynert, Thomson Reuters Foundation

Ka Lar Nar caught malaria for the sixth time when he was working away from home on his small farm in the jungle of southeastern Myanmar but this time it was a lot harder to get rid of it. MIN SAW, Myanmar (Thomson Reuters Foundation) - After testing positive for ... continue reading


Growing the Church in China

Image of

By John Smagula

The world's best teas are grown in China, but many of these teas are unknown in the United States. Remote tea farms in exotic locations produce teas that rarely reach the American teacup. Of the 1.75 million tons of tea that China produces each year, less than 2% is ... continue reading


Superbugs strike again: 10 million expected to die annually by 2050 Watch

Image of Drug resistant infections, like E. coli, are expected to resist more antibiotics, making infection prevention impossible.

By Abigail James (NEWS CONSORTIUM)

Drug resistant infections currently cause 700,000 deaths worldwide each year. If something is not done to adamantly fight against antimicrobial resistance, a new study professes that number will grow. LOS ANGELES, CA (Catholic Online) - Antimicrobial resistance will ... continue reading


If they can't heave health care than neither should you! The hidden agenda behind Obamacare! Watch

Image of President Obama's Affordable Care Act has failed utterly and completely. It has done nothing but harm the United States and its citizens through direct action and ignorance.

By Matt Waterson (NEWS CONSORTIUM)

When President Obama undertook his extensive campaign to pass the Affordable Care Act (ACA) one of his chief promises was that individuals were guaranteed the right to keep their current physicians, another was that the ACA would allow those on the new health ... continue reading


Explorer Christopher Columbus did not bring 'STD's' back to Europe Watch

Image of Christopher Columbus has a lot to answer for -- but according to some scientists, bringing syphilis from the new world to the old was not one of them.

By Catholic Online (NEWS CONSORTIUM)

Spanish explorer Christopher Columbus had a lot to answer for - but bringing back syphilis from the new world to Europe was not one of them. A skeleton excavated from a grave in Croatia has disproven this theory, suggesting that the sexually transmitted disease ... continue reading


GOOD NEWS: HIV's ability to cause AIDS weakening worldwide, study finds Watch

Image of Some 35 million people currently have HIV and AIDS has killed around 40 million people since it began spreading 30 years ago.

By Catholic Online (NEWS CONSORTIUM)

Just in time for World AIDS Day, December 1st. comes some most encouraging news: The world has finally reached "the beginning of the end" of the AIDS pandemic, a leading campaign group claimed today. LOS ANGELES, CA (Catholic Online) - According to a study of ... continue reading


Fountain of Youth discovered at last? Revolutionary wrinkle cream heralded Watch

Image of Created by Professor Chris Toumazou, Regius Professor at Imperial College London, among his many other accomplishments invented the cochlear ear implant, the artificial pancreas for Type 1 diabetics and the wireless heart monitor.

By Catholic Online (NEWS CONSORTIUM)

Emollients, moisturizers and facial scrubs are typically used by consumers to keep unsightly wrinkles off the face. Many forego aging gracefully and strive to maintain a youthful face well past middle age. Now, a brand new "wrinkle cream" which uses the client's ... continue reading


How the Obama administration just sued itself over Obamacare enforcement Watch

Image of Obamacare may be intended to have a disruptive impact on medical care, leaving the government as the only agency which can resolve the problems it has itself created.

By Marshall Connolly, Catholic Online (NEWS CONSORTIUM)

Obama may face added backlash against his signature healthcare plan as leading CEOs are challenging Obama's "workplace wellness" programs. Although Obamacare has largely been popular with big businesses in the US, its interference with business practices are proving ... continue reading


HEALTH CARE MAJOR FAILURE: One in three Americans postponing medical care due to costs, poll says Watch

Image of Those who already had health coverage are frequently seeing their deductibles go up along with their premiums.

By Catholic Online (NEWS CONSORTIUM)

Health care reform was supposed to make health care more affordable - it obviously didn't work as one in three Americans has put off seeking medical treatment in 2014 due to high costs. Especially shameful is the fact that this is the highest percentage since ... continue reading


DIAGNOSIS BREAKTHROUGH: Doctors may soon detect 'pre-cancers' in blood samples Watch

Image of The teams independently found three genes whose mutations accounted for most of the blood cancer risk they saw.

By Catholic Online (NEWS CONSORTIUM)

Two separate studies testing the DNA of people have yielded what may be a diagnostic breakthrough. It's been learned that many older people silently harbor a blood "pre-cancer." This is a gene mutation acquired during the course of a lifetime that could start ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Saint of the Day

Saint of the Day for December 18th, 2014 Image

St. Rufus
December 18: Rufus and Zosimus were citizens of Antioch (or perhaps Philippi) ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter