Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

2/22/2013 (2 years ago)

Catholic Online (

Kadcyla can cause heart, liver damage and birth defects

Kadcyla or ado-trastuzumab emtansine is a new drug for late-stage breast cancer patients that have dangerous side effects. Produced by Swiss drug-maker Roche, Kadcyla is for patients with late-stage metastatic breast cancer who fail to respond to other therapies.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.


By Catholic Online (NEWS CONSORTIUM)

Catholic Online (

2/22/2013 (2 years ago)

Published in Health

Keywords: Kadcyla, breat cancer, Food and Drug Administration, Roche

LOS ANGELES, CA (Catholic Online) - The U.S. Food and Drug Administration approved Kadcyla this week, noting it was for patients whose cancer cells contain increased amounts of a protein known as HER2.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Patients who took the drug in clinical trials survived an average of 30.9 months, compared with 25.1 months in a control group.

It's estimated that Kadcyla could generate annual peak sales of $1.9 billion as usage in different settings increases. The drug will be priced at $9,800 a month.

"We don't expect to see significant payer push back on pricing at launch, given the drug's efficacy and safety," Simos Simeonidis, an analyst at Cowen and Company wrote in a research note.

Kadcyla works by attaching trastuzumab, sold under the brand name Herceptin, to a drug called DM1, developed by ImmunoGen Inc, which interferes with cancer cell growth.

"Kadcyla delivers the drug to the cancer site to shrink the tumor, slow disease progression and prolong survival," Dr. Richard Pazdur, director of the FDA's office of hematology and oncology products says. "It is the fourth approved drug that targets the HER2 protein."

Other drugs approved for the disease include Herceptin in 1998, lapatinib, made by GlaxoSmithKline Plc and sold under the brand name Tykerb in 2007, and pertuzumab, marketed as Perjeta and also made by Roche in 2012.

Kadcyla is the first drug in its class, known as antibody-drug conjugates, or "armed antibodies" to be approved to treat a solid tumor. These drugs combine an antibody, Herceptin in the case of Kadcyla, with a killer toxin, in this case ImmunoGen's DM1, and links them together to deliver a highly potent bomb to the diseased cells.

The drugs seek out specific cells that express proteins associated with the cancer, while leaving other cells unharmed.

Breast cancer is the second-leading cause of cancer-related death among women.


Pope Francis: end world hunger through 'Prayer and Action'

Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for October 2015
That human trafficking, the modern form of slavery, may be eradicated.
Evangelization: That with a missionary spirit the Christian communities of Asia may announce the Gospel to those who are still awaiting it.


More Health

America drinks less soda: The soda industry sees an all-time-low in sales Watch

Image of The soda industry is changing.


Around five years ago, the soda industry fought back against Mayor Michael A. Nutter's proposal of imposing soda taxes in Philadelphia. Soda lobbyists back then organized protests and came up with campaign contributions to local politicians, with the assistance of ... continue reading

5 things people need to know about breast cancer Watch

Image of


Breast cancer is the most prevalent kind of disease that has been affecting women from all over the world. The World Health Organization estimated around 508,000 women die of this disease every year.  LOS ANGELES, CA (Catholic Online) - While some women fall prey ... continue reading

Early detection test can lead to breast cancer diagnoses before cancer appears Watch

Image of Breast Cancer Awareness Month.


A recent study may make it possible to detect breast cancer before the disease develops. Researchers clarified, however, that the study was based on genetic changes from samples taken from healthy breasts and cancerous breasts. LOS ANGELES, CA (Catholic Online) - The ... continue reading

ACLU sues Catholic hospital over refusal to abort children Watch

Image of The ACLU is insisting that Catholic hospitals abort still-living children.

By Catholic Online (NEWS CONSORTIUM)

The ACLU is suing Trinity Health Corporation, a Michigan-based Catholic hospital chain, because the organization refuses to perform abortions. The suit is similar to one brought by the ACLU in 2013, that case was dismissed by a Federal court. LOS ANGELES, CA (Catholic ... continue reading

Baby born with rare medical mystery thrives Watch

Image of Baby Angelito was born with two tubes for a nose.


Baby Angelito was born with two tubes in place of a nose but his doctors are optimistic about his condition.  LOS ANGELES, CA (Catholic Online) - Daily Mail reported the medical mystery as well as Angelito's doctors' belief the infant will soon appear normal.The ... continue reading

20-million-year old flea carrying bubonic plague may be real reason dinosaurs went extinct Watch

Image of The Black Death plague devastated entire populations (Interfoto/Alamy)


Preserved in amber, a 20-million-year-old flea is believed to contain an ancient form of one of the world's deadliest bacteria: Black Death.  LOS ANGELES, CALIFORNIA (Catholic Online) - According to the Journal of Medical Entomology, the fossilized bacteria is ... continue reading

Baby born missing majority of skull miraculously beats the odds, reaches first birthday Watch

Image of


Doctors said that Jaxon Buell only had a few days to live after his birth. The boy was born with a rare condition called the Microhydranencephaly, which left the majority of his skull unable to form. Despite the odds, Jaxon is strong and recently celebrated a milestone ... continue reading

New dangerous cluster of Legionnaires' disease reported in the Bronx Watch

Image of Legionnaires' disease is a lung bacteria that causes flue-like muscle pain, headaches, fevers, drowsiness, chills and in some cases delirium.

By Kenya Sinclair (NEWS CONSORTIUM)

A new cluster of Legionnaires' disease has been reported in the Bronx and is not related to the cluster outbreak in the Bronx earlier this summer that left 12 dead. NEW YORK CITY, NY (Catholic Online) - Fox5ny reported seven cases of Legionnaires' disease in the ... continue reading

Why fidgeting may actually be good for your health Watch

Image of


When you feel like fidgeting, don't worry about whether it's bad for you or not. New research shows that being restless and fidgeting at work can actually be good for your health. HOLLYWOOD, CA  (Catholic Online) - A series of studies showed that long periods of ... continue reading

What you need to know about the developmental process of Influenza Watch

Image of Inflammation associated with infection in the soft palate stimulates the sneezing and coughing. This propels the flu virus out of the mouth enabling it to spread easily.

By Catholic Online (NEWS CONSORTIUM)

Influenza, or "Flu," the respiratory ailment that hits hardest during the colder months, first develops on the roof of the mouth. That's the findings of researchers, who note that flu is then spread through coughs and sneezes. LOS ANGELES, CA (Catholic Online) ... continue reading

All Health News


Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Subscribe to Catholic OnlineYouTube Channel

Daily Readings

Reading 1, Joel 1:13-15; 2:1-2
13 Priests, put on sackcloth and lament! You ... Read More

Psalm, Psalms 9:2-3, 6, 16, 8-9
6 the enemy is wiped out -- mere ruins for ever -- ... Read More

Gospel, Luke 11:15-26
15 But some of them said, 'It is through Beelzebul, ... Read More

Saint of the Day

Saint of the Day for October 9th, 2015 Image

Sts. Denis, Rusticus, and Eleutherius
October 9: The first mention we have of these three martyrs who died around ... Read More