Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

2/22/2013 (2 years ago)

Catholic Online (www.catholic.org)

Kadcyla can cause heart, liver damage and birth defects

Kadcyla or ado-trastuzumab emtansine is a new drug for late-stage breast cancer patients that have dangerous side effects. Produced by Swiss drug-maker Roche, Kadcyla is for patients with late-stage metastatic breast cancer who fail to respond to other therapies.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

2/22/2013 (2 years ago)

Published in Health

Keywords: Kadcyla, breat cancer, Food and Drug Administration, Roche


LOS ANGELES, CA (Catholic Online) - The U.S. Food and Drug Administration approved Kadcyla this week, noting it was for patients whose cancer cells contain increased amounts of a protein known as HER2.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Patients who took the drug in clinical trials survived an average of 30.9 months, compared with 25.1 months in a control group.

It's estimated that Kadcyla could generate annual peak sales of $1.9 billion as usage in different settings increases. The drug will be priced at $9,800 a month.

"We don't expect to see significant payer push back on pricing at launch, given the drug's efficacy and safety," Simos Simeonidis, an analyst at Cowen and Company wrote in a research note.

Kadcyla works by attaching trastuzumab, sold under the brand name Herceptin, to a drug called DM1, developed by ImmunoGen Inc, which interferes with cancer cell growth.

"Kadcyla delivers the drug to the cancer site to shrink the tumor, slow disease progression and prolong survival," Dr. Richard Pazdur, director of the FDA's office of hematology and oncology products says. "It is the fourth approved drug that targets the HER2 protein."

Other drugs approved for the disease include Herceptin in 1998, lapatinib, made by GlaxoSmithKline Plc and sold under the brand name Tykerb in 2007, and pertuzumab, marketed as Perjeta and also made by Roche in 2012.

Kadcyla is the first drug in its class, known as antibody-drug conjugates, or "armed antibodies" to be approved to treat a solid tumor. These drugs combine an antibody, Herceptin in the case of Kadcyla, with a killer toxin, in this case ImmunoGen's DM1, and links them together to deliver a highly potent bomb to the diseased cells.

The drugs seek out specific cells that express proteins associated with the cancer, while leaving other cells unharmed.

Breast cancer is the second-leading cause of cancer-related death among women.

---


Pope Francis: end world hunger through 'Prayer and Action'


Copyright 2015 - Distributed by THE CALIFORNIA NETWORK

Pope Francis Prayer Intentions for February 2016
Universal:
That prisoners, especially the young, may be able to rebuild lives of dignity.
Evangelization: That married people who are separated may find welcome and support in the Christian community.



Comments


More Health

Low-carb is so last year! This year incorporate more grains like barley! Watch

Image of Is barley the new superfood (CureJoy)?

By Kenya Sinclair (CALIFORNIA NETWORK)

Did you resolve to eat healthier this year? Did you promise yourself you would lose weight? You're in luck! Barley may be the first step on the road to weight-loss and healthy eating. LOS ANGELES, CA (Catholic Online) - For the past few years, people have sworn off ... continue reading


Can science STOP breast cancer from spreading? Watch

Image of Scientists are one step closer to stopping breast cancer in its tracks (Rudyanto Wijaya/iStock).

By Kenya Sinclair (CALIFORNIA NETWORK)

Researchers believe they have discovered a protein that can prevent the spread of breast cancer! LOS ANGELES, CA (Catholic Online) - The protein, called EPHA2, was discovered to stop cancer cells from leaving blood vessels and spreading to other areas.The Cancer ... continue reading


No human rights for the unborn - UN proposes to kill babies, instead of Zika virus Watch

Image of UN Human Rights Commissioner, Jordanian Prince Zeid Ra'ad Zeid Al-Hussein [not pictured], has suggested abortion as a solution to the Zika crisis.

By David Drudge (CALIFORNIA NETWORK)

The UN is now politicizing the spread of the Zika virus to promote abortion. The virus, which is carried by mosquitoes and can also be transmitted sexually, causes significant birth defects in children resulting in lifelong developmental and cognitive impairment. The ... continue reading


Native American Health Facilities 'Horrifying' Practices: Woman dies on floor of hospital room after staff causes her to overdose Watch

Image of Native American health facilities (not pictured) are so underfunded that poorly trained staff are responsible for serious illnesses and even preventable deaths.

By Kenya Sinclair (CALIFORNIA NETWORK)

During a Senate hearing on Wednesday, several witnesses stepped forward to ask the federal government to fund the struggling Indian Health Service, only to be told that government officials were unable to procure the necessary resources. LOS ANGELES, CA (Catholic ... continue reading


Florida Gorvernor declares state of emergency with Zika virus outbreak Watch

Image of At least nine people have been diagnosed with the Zika Virus in Florida (James Gathany/CDC).

By Kenya Sinclair (CALIFORNIA NETWORK)

Florida Governor Rick Scott declared a state of emergency after nine cases were diagnosed from people who travelled to Zika-dense regions. LOS ANGELES, CA (Catholic Online) - The state of emergency affects Tampa Bay, south and southwest Florida and Santa Rosa County. ... continue reading


Zika virus sexually transmitted in first U.S. case Watch

Image of Zika has been transmitted within the United States.

By Kenya Sinclair (CALIFORNIA NETWORK)

The first known case of the Zika virus being locally acquired in the United States has occured in Dallas, Texas. LOS ANGELES, CA (Catholic Online) - Dallas County health officials confirmed a recent traveler to Venezuela infected their partner after a sexual ... continue reading


Has the origin of the dangerous Zika virus been found? What really started the outbreak? Watch

Image of Women returning from affected areas are being warned to postpone conceive for at least a month in case they have been infected (India News).

By Catholic Online (CALIFORNIA NETWORK)

Most of Latin America - along with the rest of the world, is frantically trying to come to grips with an outbreak of Zika. The mosquito-borne illness usually leaves patients with mild, flu-like symptoms but causes a wide variety of birth defects to expectant ... continue reading


Scientists get permission to carry out horrifying genetic experiments on babies, then destroy them! Watch

Image of The era of designer babies is about to begin. The only cost is the lives of hundreds, possibly thousands of other babies.

By Marshall Connolly, Catholic Online (CALIFORNIA NETWORK)

Scientists in England have been given permission to start genetic experiments with unborn children. The scientists intend to turn off genes in between 30 - 120 unborn children just to see what happens. They claim the experiments will give them new insights that can aid ... continue reading


Is Alzheimer's contagious? Find out NOW! Watch

Image of Doctors continue to investigate whether Alzheimer's can be spread from one person to another (Alamy).

By Kenya Sinclair (CALIFORNIA NETWORK)

Professor John Collinge, the head of neurodegenerative disease at University College London, believes Alzheimer's disease can by transmissible from one person to another during invasive medical procedures -but is he right? LOS ANGELES, CA (Catholic Online) - In a study ... continue reading


Zika virus may halt Olympics as WHO calls emergency meeting for explosive spread of the virus Watch

Image of The Zika virus continues to spread, leading to babies born with smaller-than-normal heads and brain damage (Reuters).

By Kenya Sinclair (CALIFORNIA NETWORK)

Zika virus spreads so quickly and leaves such devastating effects on babies that Rio's Olympics may be cancelled. Meanwhile, the World Health Organization (WHO) has called an emergency meeting following explosive outbreaks. LOS ANGELES, CA (Catholic Online) - According ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Subscribe to Catholic OnlineYouTube Channel

the FEED
by Catholic Online

Daily Readings

Reading 1, Deuteronomy 30:15-20
15 'Look, today I am offering you life and prosperity, death and ... Read More

Psalm, Psalms 1:1-2, 3, 4, 6
1 How blessed is anyone who rejects the advice of the wicked and does not ... Read More

Gospel, Luke 9:22-25
22 He said, 'The Son of man is destined to suffer grievously, to be ... Read More

Saint of the Day

Saint of the Day for February 11th, 2016 Image

St. Paschal
February 11: Paschal was the son of Bonosus, a Roman. He ... Read More