Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

2/22/2013 (2 years ago)

Catholic Online (www.catholic.org)

Kadcyla can cause heart, liver damage and birth defects

Kadcyla or ado-trastuzumab emtansine is a new drug for late-stage breast cancer patients that have dangerous side effects. Produced by Swiss drug-maker Roche, Kadcyla is for patients with late-stage metastatic breast cancer who fail to respond to other therapies.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

2/22/2013 (2 years ago)

Published in Health

Keywords: Kadcyla, breat cancer, Food and Drug Administration, Roche


LOS ANGELES, CA (Catholic Online) - The U.S. Food and Drug Administration approved Kadcyla this week, noting it was for patients whose cancer cells contain increased amounts of a protein known as HER2.

Kadcyla has the potential to cause liver and heart damage or even death, as well as cause life-threatening birth defects. A warning label will be affixed on all packaging.

Patients who took the drug in clinical trials survived an average of 30.9 months, compared with 25.1 months in a control group.

It's estimated that Kadcyla could generate annual peak sales of $1.9 billion as usage in different settings increases. The drug will be priced at $9,800 a month.

"We don't expect to see significant payer push back on pricing at launch, given the drug's efficacy and safety," Simos Simeonidis, an analyst at Cowen and Company wrote in a research note.

Kadcyla works by attaching trastuzumab, sold under the brand name Herceptin, to a drug called DM1, developed by ImmunoGen Inc, which interferes with cancer cell growth.

"Kadcyla delivers the drug to the cancer site to shrink the tumor, slow disease progression and prolong survival," Dr. Richard Pazdur, director of the FDA's office of hematology and oncology products says. "It is the fourth approved drug that targets the HER2 protein."

Other drugs approved for the disease include Herceptin in 1998, lapatinib, made by GlaxoSmithKline Plc and sold under the brand name Tykerb in 2007, and pertuzumab, marketed as Perjeta and also made by Roche in 2012.

Kadcyla is the first drug in its class, known as antibody-drug conjugates, or "armed antibodies" to be approved to treat a solid tumor. These drugs combine an antibody, Herceptin in the case of Kadcyla, with a killer toxin, in this case ImmunoGen's DM1, and links them together to deliver a highly potent bomb to the diseased cells.

The drugs seek out specific cells that express proteins associated with the cancer, while leaving other cells unharmed.

Breast cancer is the second-leading cause of cancer-related death among women.

---


Pope Francis: end world hunger through 'Prayer and Action'


Copywriter 2015 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for March 2015
Universal:
Scientists: That those involved in scientific research may serve the well-being of the whole human person.
Evangelization: Contribution of women: That the unique contribution of women to the life of the Church may be recognized always.



Comments


More Health

You have to see it to believe it: Woman comes back from the dead THIRTY-SIX TIMES in a single year Watch

Image of

By Catholic Online (NEWS CONSORTIUM)

Twenty-one-year-old Sara Brautigam, due to her heart condition, has endured many brushes with death. She was clinically pronounced dead 36 times in a single year. Unfortunately, her visions of the "afterlife" have been disappointing so far. LOS ANGELES, CA ... continue reading


Danger in water: Unclean water claims more women's lives worldwide than breast cancer, AIDS Watch

Image of Nearly 800,000 women die every year because they lack access to safe toilets and clean water.

By Maria Caspani, Thomson Reuters Foundation

Diseases spread through dirty water and poor sanitation are the fifth biggest killer of women worldwide, causing more deaths than AIDS, diabetes or breast cancer, researchers say. NEW YORK (Thomson Reuters Foundation) - Nearly 800,000 women die every year because ... continue reading


Paying it forward with gift of life: Six people to donate kidneys to strangers Watch

Image of Zully Broussard simply wanted to help one person after her previous attempt to donate a kidney to a friend fell through.

By Catholic Online (NEWS CONSORTIUM)

"I didn't realize it was going to be this big," 55-year-old Zully Broussard says. Broussard will be donating her kidney to a total stranger. Not only that, five other people will be doing the same thing at Pacific Campus of California Pacific Medical Center in ... continue reading


Are you living a risky life? Chronic sleep deprivation proves fatal Watch

Image of

By Hannah Raissa Marfil (NEWS CONSORTIUM)

Contrary hasty conclusions made by research, it is not excessive sleeping that causes death. Instead, it is the other way around. Lack of sleep has been found to cause high blood pressure, heart diseases and diabetes. MUNTINLUPA, PHILIPPINES (Catholic Online) - ... continue reading


'Superbugs' attack two hospitals, hard-to-clean medical equipment to blame Watch

Image of The scopes, which are flexible tubes that carry a camera and other equipment into the body through the mouth, treat patients with pancreatic cancer and other serious illnesses.

By Catholic Online (NEWS CONSORTIUM)

A hospital in California and another hospital in Connecticut have reported that they have discovered drug-resistant "superbugs" on a hard-to-clean type of medical equipment under federal scrutiny. According to the Food and Drug Administration, duodenoscopes, ... continue reading


'Smoking is even deadlier than we thought' New study gives alarming statistics for smokers Watch

Image of The Centers for Disease Control and Prevention estimates about 42.1 million Americans smoke cigarettes, a habit which remains the number one cause of preventable disease and death in the U.S.

By Catholic Online (NEWS CONSORTIUM)

Smoking cigars and cigarettes has long been the source of various cancers, such as lung and mouth cancers, and has been linked to heart attack, stroke and high blood pressure. New research from Australian medical examiners have now discovered that the practice ... continue reading


Paging Dr. Frankenstein! Human head transplant possible in just two years Watch

Image of Dr. Sergio Canavero said he would expect the patient to be able to move and feel their face when they awoke, they would speak with the same voice. They would be able to walk within a year.

By Catholic Online (NEWS CONSORTIUM)

The procedure would be beneficial to humankind - and help those who are stricken with devastating disease. When we learn of the process, however, the first thing to pop into our heads is hunchbacked assistants and green-faced monsters. A human heads transplant ... continue reading


Shocking 'medical miracle' birth startles doctors and parents Watch

Image of (Cedars-Sinai Medical Center in Los Angeles)

By Abigail James (NEWS CONSORTIUM)

Now dubbed a "medical miracle," the birth of Silas Philips took doctors by surprise when he was born still inside his amniotic sac. Silas' birth miracle is extremely rare, only 1 in 80,000 births are similar to his. LOS ANGELES, CA (Catholic Online) - When his mother ... continue reading


New pill dramatically cuts risk for AIDS transmission in homosexual men Watch

Image of Some 545 HIV-negative gay men, who were sexually active and had recently had unprotected sex, were recruited to the study.

By Catholic Online (NEWS CONSORTIUM)

A daily pill, pre-exposure prophylaxis, or PrEP has been found to dramatically cut a person's risk of contracting HIV. Following a trial in the United Kingdom, advocates say the drug must be made available as soon as possible. LOS ANGELES, CA (Catholic Online) ... continue reading


AT RISK: Formula-fed babies at risk for ingesting ARSENIC Watch

Image of While arsenic in home tap water was a source of the naturally occurring chemical, poisonous in large doses, the formula itself was a contributing factor as well.

By Catholic Online (NEWS CONSORTIUM)

Breastfeeding has long been deemed the healthiest nursing option for newborns. A new study from Dartmouth College bears this out: According to researchers, arsenic levels were more than seven times higher in formula-fed babies than in breastfed ones. LOS ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Genesis 37:3-4, 12-13, 17-18
3 Jacob loved Joseph more than all his other sons, ... Read More

Psalm, Psalms 105:16-17, 18-19, 20-21
16 He called down famine on the land, he took away ... Read More

Gospel, Matthew 21:33-43, 45-46
33 'Listen to another parable. There was a man, a ... Read More

Saint of the Day

Saint of the Day for March 6th, 2015 Image

St. Colette
March 6: Colette was the daughter of a carpenter named DeBoilet at Corby ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter