Wonder drug can help cut cholesterol for those unable to take statins
Called ALN-PCS, cuts levels of 'bad' cholesterol by more than half
A fresh, new treatment called ALN-PCS is able to cut levels of "bad" cholesterol by more than half. Which is typically reduced by statins. The new drug is being heralded as a breakthrough to patients who are unable to take statins.
People were randomly assigned to receive either an injection of ALN-PCS or saline as a placebo. It was found that a single dose of the drug cut LDL levels by up to 57 percent.
Human tests involved 32 healthy volunteers with high LDL, or "bad" cholesterol. People were randomly assigned to receive either an injection of ALN-PCS or saline as a placebo. It was found that a single dose of the drug cut LDL levels by up to 57 percent.
AS was published in the medical journal The Lancet, the bigger the dose of the drug, the greater the reduction in LDL.
ALN-PCS, likely be developed in a pill form, "could be used for the one in five heart disease patients intolerant or resistant to statins, or to enhance their effects," trial investigator Kevin Fitzgerald, from Alnylam Pharmaceuticals says.
ALN-PCS works by blocking the production of the cholesterol regulator PCSK9, which is a protein that destroys low-density lipoprotein, or LDL receptors that normally clear LDL cholesterol from the blood.
Studies have proven that the mutations resulting in a rise in PCSK9 activity lead to a major increase in LDL cholesterol which contributes to the build up of plaque inside blood vessels, while genetic variants that cause less PCSK9 activity lower cholesterol dramatically.
"People with extremely high cholesterol are at increased risk of a heart attack and this approach could offer new hope for those who are resistant to statins," Professor Peter Weissberg, medical director at the British Heart Foundation says.
"These initial results add to growing evidence that blocking the action of a certain protein can dramatically lower 'bad' LDL cholesterol. More research is now needed to confirm this approach is both safe and effective at preventing heart attacks in the long term before it becomes widely available."
Click here to learn about our Saint Michael the Archangel conference this Nov 1-3!
© 2014 - Distributed by THE NEWS CONSORTIUM
Pope Francis Prayer Intentions for March 2014
Respect for Women: That all cultures may respect the rights and dignity of women.
Vocations: That many young people may accept the Lordís invitation to consecrate their lives to proclaiming the Gospel.
Rate This Article
Leave a Comment
More Health News
- Malaria cases spread to higher elevations
- Alzheimer's to join cancer, heart disease as one of America's top fatal conditions
- Birthing centers not provided for under health care reform
- Lots of proteins can BE BAD FOR YOU! 'As bad for health as smoking,' new study finds
- OUTBREAK: 53 people in 10 states stricken with measles
- Popular overdose drug rises in cost, to keep up with demand
- ANCIENT SCOURGE: leprosy, still very much alive in the world today, goes back 10 million years
- CONTROVERSY: Is dyslexia a 'meaningless label' to excuse bad reading skills?
- Horrid polio-like disease stalking children in California, may be very widespread
- Fr. Paul Schenck: Finding Living Faith on Catechetical Sunday
- The Movie Yellow: Incest as 'Normal' and Cassavates's Slides Into the World of Woes
- The Chicago School Teachers Strike Reveals the Need For School Choice
- The Sexual Barbarians and the Dissolution of Culture
- The Happy Priest Challenges Us to Ask: Who is Jesus to Me?
- Michael Coren on Canadian Public Schools: Teachers, leave those kids alone
- We Cannot Ignore Our Consciences: Cardinal Dolan On Religious Liberty
- In the Face of Danger, Successor of Peter Travels to Lebanon as a Messenger of Peace
- Reflections on the Dignity and Vocation of Women: Who or What?