LOS ANGELES, Ca (Catholic Online) - Using a new database of genetic information, researchers have found that raising HDL levels may have no effect on heart disease risk. Instead, the study suggests people are born with genes that determine the amount of HDL that naturally occurs in their blood. Researchers expected that people with naturally high levels should have lower risk of heart disease, but despite those levels, their incidence of risk was the same. 

This is a disturbing concern for doctors who worry about pharmaceutical companies developing HDL increasing drugs. So far, none of the three tested drugs that raise HDL levels have succeeded in reducing risk. 

In another clinical trial, patients who have been told to exercise or consume niacin have also failed to reduce their risk. 

However, HDL might not be completely ineffective. Dr. Steven Nissen chairman of cardiovascular medicine at the Cleveland Clinic, said he remains hopeful that HDL is still useful in the fight against heart disease. "I am an optimist," he said. 

Nissen suggested that the relationship between HDL and heart disease may be complex and still HDL still has some protective value. 

Doctors still concede that there appears to be a relationship between high HDL levels and lower risk of heart disease, but the relationship probably isn't as direct as believed. 

However, doctors still caution that the bad cholesterol, LOL is still bad. It pays to reduce LDL levels by any practical means. 

In the meantime, patients may want to revisit the issue with their doctors as more research is done, but it is not recommended that any significant changes be made until the latest results are verified and doctors decide what alternative course to take - if any.

The study was published on Wednesday in the online edition of The Lancet. 

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